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The Niners odds to win the Super Bowl are off the board.
The Niners odds to win the NFC Championship are off the board.
The Niners odds to win the NFC West are +125.
The Los Angeles Chargers (2-1-0) visit Levi’s Stadium to take on the San Francisco 49ers (1-1-0) on Aug. 23. Kickoff is scheduled for 8:30pm EDT in Santa Clara, CA. The 49ers are betting favorit Read More
Get the latest 2025 49ers over under wins for their NFL season win total, along with their 2025 win total odds and win total predictions. Read More
The San Francisco 49ers (0-1-0) visit Allegiant Stadium to take on the Las Vegas Raiders (0-0-1) on Aug. 16. Kickoff is scheduled for 4:00pm EDT in Las Vegas, NV, NV. The – are betting favorites Read More
Get my NFL player props for the 2025 NFL season based on NFL odds from the BetMGM online sportsbook, including Christian McCaffrey. Read More
Get the latest Brock Purdy MVP odds for the 2025-26 NFL season based on prices from the BetMGM online sportsbook. Read More
How many points will the 49ers score this season? Get the odds for San Francisco’s regular-season point total from the BetMGM sportsbook. Read More
Here are the only four quarterbacks who have won both a college football national championship and a Super Bowl. Read More
Get my Super Bowl predictions for the winner of Super Bowl 60 based on Super Bowl odds from BetMGM, including the 49ers (+1600). Read More
Get a list of my predictions for this year’s NFL awards at the NFL Honors ceremony based on NFL odds from BetMGM. Read More
You can bet on spread, moneylines, over/under totals, parlays, and more San Francisco 49ers odds each season.
If you’re in San Francisco and interested in odds for other teams, check out:
Will the 49ers win the NFC West? Will they win the Super Bowl? How many interceptions will a certain player have this year?
For example: If you bet $20 on the 49ers (+200) to win the division, the bet would settle when the 49ers are eliminated or when they clinch the division.
What’s the final scoring margin of the 49ers’ game?
For example: If you bet $200 on the 49ers -3.5 (-115) against the Carolina Panthers, San Francisco must win the game by at least four points.
Alternatively, if you bet $200 on the 49ers +4.5 (-110) against the Philadelphia Eagles, San Francisco must lose by four or fewer points (or win the game).
If the scoring margin is identical to the spread (e.g., -2 or +7), the bet is a push, and your money is refunded.
Will the 49ers win the matchup?
For example: If you bet $50 on the 49ers -200 against the Miami Dolphins, San Francisco must win the game (in regulation or overtime).
If the game ends in a tie, the bet is a push.
What is the number of points scored by both teams in the game?
For example: If you bet $15 on over 49.5 (-110) in their game against the Detroit Lions, the teams must combine for at least 50 points.
Alternatively, if you bet $25 on under 29.5 (-110), the teams must combine for 29 or fewer points.
If the combined point total is identical to the over/under total, the bet is a push.
You can combine 49ers’ bets and other NFL bets into one parlay.
For example: If you bet $10 on a three-leg parlay with the 49ers’ moneyline (+110) vs. the Buffalo Bills, Falcons’ moneyline (-125 vs. the Las Vegas Raiders), and over 49.5 (-115) in the Pittsburgh Steelers-Cincinnati Bengals game, all three legs must hit for the bet to cash.
If one bet is a push, it’s eliminated from the parlay, and odds (and payout) are recalculated without that leg.
Read the latest betting tips and how-to guides from BetMGM experts.
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