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The Niners odds to win the Super Bowl are off the board.
The Niners odds to win the NFC Championship are off the board.
The Niners odds to win the NFC West are +125.
Get my NFC West prediction, along with NFC West odds and standings, for the 2025 division winner based on NFL odds at BetMGM. Read More
The San Francisco 49ers (5-3-0) visit MetLife Stadium to take on the New York Giants (2-6-0) on Nov. 2. Kickoff is scheduled for 1:00pm EDT in East Rutherford, NJ. The are betting favorites in this ma Read More
The San Francisco 49ers (5-2-0) visit NRG Stadium to take on the Houston Texans (2-4-0) on Oct. 26. Kickoff is scheduled for 1:00pm EDT in Houston, TX. The Texans are betting favorites in this matchup Read More
Get two player prop bets for 49ers vs Falcons on Sunday Night Football based on NFL odds from the BetMGM online sportsbook. Read More
See the latest NFL Week 7 odds, picks and predictions for 49ers vs. Falcons on October 19 at Levi’s Stadium. Read More
The Atlanta Falcons (3-2-0) visit Levi's Stadium to take on the San Francisco 49ers (4-2-0) on Oct. 19. Kickoff is scheduled for 8:20pm EDT in Santa Clara, CA. The are betting favorites in this m Read More
The San Francisco 49ers (4-1-0) visit Raymond James Stadium to take on the Tampa Bay Buccaneers (4-1-0) on Oct. 12. Kickoff is scheduled for 4:25pm EDT in Tampa, FL. The Buccaneers are betting favorit Read More
See the latest NFL Week 5 odds, picks and predictions for Rams vs. 49ers on October 2 at SoFi Stadium in Los Angeles. Read More
The San Francisco 49ers (3-1-0) visit SoFi Stadium to take on the Los Angeles Rams (3-1-0) on Oct. 2. Kickoff is scheduled for 8:15pm EDT in Inglewood, CA. The Rams are betting favorites in this match Read More
You can bet on spread, moneylines, over/under totals, parlays, and more San Francisco 49ers odds each season.
If you’re in San Francisco and interested in odds for other teams, check out:Â
Will the 49ers win the NFC West? Will they win the Super Bowl? How many interceptions will a certain player have this year?
For example: If you bet $20 on the 49ers (+200) to win the division, the bet would settle when the 49ers are eliminated or when they clinch the division.
What’s the final scoring margin of the 49ers’ game?
For example: If you bet $200 on the 49ers -3.5 (-115) against the Carolina Panthers, San Francisco must win the game by at least four points.Â
Alternatively, if you bet $200 on the 49ers +4.5 (-110) against the Philadelphia Eagles, San Francisco must lose by four or fewer points (or win the game).
If the scoring margin is identical to the spread (e.g., -2 or +7), the bet is a push, and your money is refunded.
Will the 49ers win the matchup?Â
For example: If you bet $50 on the 49ers -200 against the Miami Dolphins, San Francisco must win the game (in regulation or overtime).
If the game ends in a tie, the bet is a push.
What is the number of points scored by both teams in the game?Â
For example: If you bet $15 on over 49.5 (-110) in their game against the Detroit Lions, the teams must combine for at least 50 points.Â
Alternatively, if you bet $25 on under 29.5 (-110), the teams must combine for 29 or fewer points.
If the combined point total is identical to the over/under total, the bet is a push.
You can combine 49ers’ bets and other NFL bets into one parlay.
For example: If you bet $10 on a three-leg parlay with the 49ers’ moneyline (+110) vs. the Buffalo Bills, Falcons’ moneyline (-125 vs. the Las Vegas Raiders), and over 49.5 (-115) in the Pittsburgh Steelers-Cincinnati Bengals game, all three legs must hit for the bet to cash.
If one bet is a push, it’s eliminated from the parlay, and odds (and payout) are recalculated without that leg.
Read the latest betting tips and how-to guides from BetMGM experts.
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