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The Niners odds to win the Super Bowl are off the board.
The Niners odds to win the NFC Championship are off the board.
The Niners odds to win the NFC West are +125.
The San Francisco 49ers (10-4-0) visit Lucas Oil Stadium to take on the Indianapolis Colts (8-6-0) on Dec. 22. Kickoff is scheduled for 8:15pm EST in Indianapolis, IN. The are betting favorites in thi Read More
See the latest NFL Week 16 odds, picks and predictions for Colts vs. 49ers on December 22 at Lucas Oil Stadium. Read More
Read about the QBs taken after the 49ers drafted Trey Lance at third overall in the 2021 NFL Draft. Read More
Read about the youngest players currently on the Niners’ roster. Read More
Read about the free agency for 49ers QB Brock Purdy. Read More
The Tennessee Titans (2-11-0) visit Levi's Stadium to take on the San Francisco 49ers (9-4-0) on Dec. 14. Kickoff is scheduled for 4:25pm EST in Santa Clara, CA. The are betting favorites in this Read More
What are the biggest NFL Week 15 matchup advantages? Get a look at where potential mismatches exist based on this week’s NFL odds. Read More
Get implied probability for the San Francisco 49ers playoff chances based on both preseason and live NFL odds for the 2025-26 NFL season. Read More
The San Francisco 49ers (8-4-0) visit Huntington Bank Field to take on the Cleveland Browns (3-8-0) on Nov. 30. Kickoff is scheduled for 1:00pm EST in Cleveland, OH. The are betting favorites in this Read More
You can bet on spread, moneylines, over/under totals, parlays, and more San Francisco 49ers odds each season.
If you’re in San Francisco and interested in odds for other teams, check out:Â
Will the 49ers win the NFC West? Will they win the Super Bowl? How many interceptions will a certain player have this year?
For example: If you bet $20 on the 49ers (+200) to win the division, the bet would settle when the 49ers are eliminated or when they clinch the division.
What’s the final scoring margin of the 49ers’ game?
For example: If you bet $200 on the 49ers -3.5 (-115) against the Carolina Panthers, San Francisco must win the game by at least four points.Â
Alternatively, if you bet $200 on the 49ers +4.5 (-110) against the Philadelphia Eagles, San Francisco must lose by four or fewer points (or win the game).
If the scoring margin is identical to the spread (e.g., -2 or +7), the bet is a push, and your money is refunded.
Will the 49ers win the matchup?Â
For example: If you bet $50 on the 49ers -200 against the Miami Dolphins, San Francisco must win the game (in regulation or overtime).
If the game ends in a tie, the bet is a push.
What is the number of points scored by both teams in the game?Â
For example: If you bet $15 on over 49.5 (-110) in their game against the Detroit Lions, the teams must combine for at least 50 points.Â
Alternatively, if you bet $25 on under 29.5 (-110), the teams must combine for 29 or fewer points.
If the combined point total is identical to the over/under total, the bet is a push.
You can combine 49ers’ bets and other NFL bets into one parlay.
For example: If you bet $10 on a three-leg parlay with the 49ers’ moneyline (+110) vs. the Buffalo Bills, Falcons’ moneyline (-125 vs. the Las Vegas Raiders), and over 49.5 (-115) in the Pittsburgh Steelers-Cincinnati Bengals game, all three legs must hit for the bet to cash.
If one bet is a push, it’s eliminated from the parlay, and odds (and payout) are recalculated without that leg.
Read the latest betting tips and how-to guides from BetMGM experts.
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