Titans vs. Colts: NFL Week 3 Odds, Prediction

See the latest NFL Week 3 odds, picks and predictions for Titans vs. Colts on September 21 at Nissan Stadium.
  • The Titans are a 5-point home underdog against the Colts.
  • The Colts have won each of their last nine games as favorites against AFC opponents.
  • My Titans vs Colts prediction is for the Titans (+4) to cover the spread.

The 2-0 Colts go for a third straight win as road favorites against the Titans in Week 3.

Indy appeared headed for a 1-1 start. However, a crucial 15-yard leverage penalty gave the Colts a second game-winning field goal try, which Spencer Shrader converted. 

The Titans, meanwhile, fell to 0-2 with a 33-19 home loss to the Rams. The loss drops Brian Callahan to 3-15-1 ATS as an NFL head coach. 

Bet on Titans vs. Colts and other NFL matchups with up-to-date NFL odds. 

Titans vs. Colts: NFL Week 3 Odds

Titans vs. Colts Prediction

Monday, September 15

Based on the past success of home divisional underdogs and the market’s love for the Colts, my Titans vs Colts prediction is the Titans Spread (+4, -105). 

The Colts look like absolute world beaters, having won two straight games. Unsurprisingly, bettors are lining up to support Indianapolis as a road favorite. 

As of Monday afternoon, Indianapolis has received 88% of ATS bets and 93% of moneyline bets. 

All of that leads me to consider the Titans at a key number. However, I want to wait and see if this line reaches +3.5 before making a final prediction for Sunday’s AFC South matchup. 

At +3, it’s a slight interest in the Titans. But at +3.5, interest would increase slightly in the Titans. 

But some trends support a bet on the Titans. 

Since 2004, divisional dogs between +2.5 and +5.5 in games 1-3 are 39-13-3 (75%) ATS, assuming two factors:

  • The dog’s previous head-to-head result falls between -17 and -3
  • The dog failed to make the postseason the prior year

Additionally, fading road favorites between -3.5 and -2.5 that closed as a home underdog in the previous game went 43-17-2 ATS since ‘04, assuming two factors:

  • The team has 6-14 days between games
  • The team’s game number falls between 2 and 10

Is there a matchup advantage for the Titans? Maybe it comes with Tony Pollard on the ground against a suspect run defense. 

If Tennessee deploys a strong run game and keeps Indianapolis’ offense off the field, maybe they cover this number. 

However, I’ll monitor this game and see if it gets to +3.5 before making a prediction. 

Betting Titans vs. Colts: NFL Public Betting

Team% of ATS Bets% of ATS Money% of ML Bets% of ML Money
Colts73%75%68%85%
Titans27%25%32%15%

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About the Author Read More @nickhennion

Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.

Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.