Titans vs Cardinals Prediction, Odds & Best Prop Bets – NFL, Week 5

BetMGM Betting Oct 01, 2025, 11:12 AM

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A detail view of an Arizona Cardinals helmet with a 9/11 decal before an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Sept. 8, 2024. (AP Photo/Adrian Kraus)

(AP Photo/Adrian Kraus)

The Cardinals are -7.5 point favorites vs the Titans
Total (Over/Under): 41.5 points
Watch this game on CBS

The Tennessee Titans (0-4-0) visit State Farm Stadium to take on the Arizona Cardinals (2-2-0) on Oct. 5. Kickoff is scheduled for 4:05pm EDT in Glendale, AZ.

The Cardinals are betting favorites in this matchup, with the spread sitting at -7.5 (-110).

The Titans vs. Cardinals Over/Under is 41.5 total points for the game.

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Titans vs. Cardinals Odds, Spread, Over/Under

	Spread	Total (O/U)	Moneyline
Titans	+7.5 -110	41.5 -110	325
Cardinals	-7.5 -110	41.5 -110	-425

Titans vs. Cardinals Prediction

The winning team model predicts the Cardinals will win this game with 74.3% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Titans vs Cardinals Spread Prediction

Based on recent against-the-spread trends, the model predicts the Cardinals will cover the spread with 59.8% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Titans players this game, looking at profitable historical betting trends:

Best Titans Player Prop Bets Today

Tony Pollard has hit the Receptions Under in 11 of his last 16 games (+6.40 Units / 34% ROI)
Tyler Lockett has hit the Receptions Under in 11 of his last 17 games (+4.80 Units / 23% ROI)
Chigoziem Okonkwo has hit the Receptions Over in 10 of his last 16 games (+4.60 Units / 25% ROI)
Tyler Lockett has hit the Receiving Yards Under in 11 of his last 17 games (+4.25 Units / 22% ROI)
Tony Pollard has hit the Rushing Yards Under in 6 of his last 8 away games (+3.70 Units / 40% ROI)

And here are some top NFL player prop bets for Cardinals players for this matchup, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today

Chad Ryland has hit the Field Goals Over in 13 of his last 17 games (+9.50 Units / 52% ROI)
Michael Wilson has hit the Receiving Yards Under in 6 of his last 7 games at home (+4.90 Units / 62% ROI)
Greg Dortch has hit the Receptions Under in 9 of his last 13 games (+4.90 Units / 28% ROI)
Kyler Murray has hit the TD Passes Under in 12 of his last 17 games (+4.40 Units / 16% ROI)
Kyler Murray has hit the Completions Over in 11 of his last 17 games (+4.25 Units / 22% ROI)

Titans Best Bets:

The Tennessee Titans have hit the Game Total Over in 8 of their last 11 away games (+4.70 Units / 39% ROI)
The Tennessee Titans have hit the 4Q Game Total Over in 11 of their last 17 games (+4.20 Units / 22% ROI)
The Tennessee Titans have hit the 1Q Moneyline in 4 of their last 9 away games (+2.70 Units / 30% ROI)
The Tennessee Titans have hit the 2Q Game Total Over in 6 of their last 9 away games (+2.60 Units / 24% ROI)
The Tennessee Titans have hit the 1H Team Total Under in 11 of their last 19 games (+0.85 Units / 4% ROI)

Cardinals Best Bets:

The Arizona Cardinals have hit the 3Q Moneyline in 11 of their last 17 games (+7.30 Units / 33% ROI)
The Arizona Cardinals have covered the 3Q Spread in 12 of their last 17 games (+6.55 Units / 31% ROI)
The Arizona Cardinals have hit the Moneyline in 8 of their last 10 games at home (+6.14 Units / 38% ROI)
The Arizona Cardinals have covered the 2H Spread in 7 of their last 8 games at home (+6.08 Units / 64% ROI)
The Arizona Cardinals have covered the Spread in 13 of their last 20 games (+5.20 Units / 23% ROI)

Titans Against the Spread (ATS) Record

Against the spread this NFL season, the Titans are 1-3 (-2.3 Units / -52.27% ROI).

Titans are 0-4 when betting on the Moneyline for -4 Units / -100% ROI
Titans are 2-2 when betting the Over for -0.2 Units / -4.55% ROI
Titans are 2-2 when betting the Under for -0.2 Units / ROI

Cardinals Against the Spread (ATS) Record

Against the spread this NFL season, the Cardinals are 2-2 (-0.2 Units / -4.55% ROI).

Cardinals are 2-2 when betting on the Moneyline for +0 Units / 0% ROI
Cardinals are 1-3 when betting the Over for -2.3 Units / -52.27% ROI
Cardinals are 3-1 when betting the Under for +1.9 Units / 43.18% ROI

Tennessee Titans: Keys to the Game vs. the Arizona Cardinals

The Cardinals have run successful plays on 32% of rush attempts this season — 2nd-worst in NFL; League Avg: 43%.

The Cardinals have run successful plays on 29% of plays in the 1st quarter this season — 2nd-worst in NFL; League Avg: 45%.

The Cardinals have run successful plays on 26% of rush attempts in the 1st half this season — worst in NFL; League Avg: 44%.

The Cardinals have run successful plays on 31% of rush attempts on play action passes since the 2024 season — 2nd-worst in NFL; League Avg: 53%.

Arizona Cardinals: Keys to the Game vs. the Tennessee Titans

The Titans have averaged -0.46 epa per play on first drive of the game this season — worst in NFL; League Avg: 0.06.

The Titans have averaged -0.25 epa per play on motion plays this season — worst in NFL; League Avg: 0.03.

The Titans have faced a blitz 131 times since the 2024 season — 2nd-fewest in NFL.

The Titans have averaged just 3.5 yards per play in the 2nd half this season — worst in NFL; League Avg: 5.6.

Additional Matchup Notes for Tennessee Titans vs. Arizona Cardinals