Titans vs 49ers Prediction, Odds & Best Prop Bets – NFL, Week 15

BetMGM Betting Dec 13, 2025, 11:20 AM

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An exterior of Levi's Stadium is shown before an NFL preseason football game between the San Francisco 49ers and the Los Angeles Chargers in Santa Clara, Calif., Thursday, Aug. 29, 2019. (AP Photo/Tony Avelar)

(AP Photo/Tony Avelar)

The Favorite Team are Favorite Spread point favorites vs the Underdog Team
Total (Over/Under): 44.5 points
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The Tennessee Titans (2-11-0) visit Levi's Stadium to take on the San Francisco 49ers (9-4-0) on Dec. 14. Kickoff is scheduled for 4:25pm EST in Santa Clara, CA.

The are betting favorites in this matchup, with the spread sitting at ().

The Titans vs. 49ers Over/Under is 44.5 total points for the game.

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Titans vs. 49ers Odds, Spread, Over/Under

	Spread	Total (O/U)	Moneyline
Titans	+12.5 -105	44.5 -110	650
49ers	+49 -115	44.5 -110	-1000

Titans vs. 49ers Prediction

The winning team model predicts the 49ers will win this game with 77.3% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Titans vs 49ers Spread Prediction

Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread with 50.2% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Titans players this game, looking at profitable historical betting trends:

Best Titans Player Prop Bets Today

Tyjae Spears has hit the Receiving Yards Over in 10 of his last 11 games (+8.75 Units / 68% ROI)
Tyjae Spears has hit the Receptions Over in 9 of his last 11 games (+7.60 Units / 54% ROI)
Chigoziem Okonkwo has hit the Receptions Over in 11 of his last 16 games (+6.65 Units / 37% ROI)
Tyjae Spears has hit the Longest Reception Over in 7 of his last 8 games (+5.95 Units / 65% ROI)
Cameron Ward has hit the Completions Over in 9 of his last 12 games (+5.55 Units / 39% ROI)

And here are some top NFL player prop bets for 49ers players for this matchup, looking at profitable historical betting trends:

Best 49ers Player Prop Best Bets Today

Christian McCaffrey has hit the Longest Rush Under in 10 of his last 13 games (+6.60 Units / 44% ROI)
Christian McCaffrey has hit the Receiving Yards Over in 10 of his last 13 games (+6.55 Units / 44% ROI)
Brock Purdy has hit the Pass Attempts Over in 7 of his last 8 games (+5.80 Units / 65% ROI)
Christian McCaffrey has hit the Receptions Over in his last 5 games at home (+5.15 Units / 88% ROI)
Christian McCaffrey has hit the Longest Reception Over in his last 5 games at home (+5.00 Units / 86% ROI)

Titans Best Bets:

The Tennessee Titans have hit the Game Total Over in 13 of their last 20 games (+5.30 Units / 24% ROI)
The Tennessee Titans have covered the 4Q Spread in 11 of their last 17 games (+4.35 Units / 22% ROI)
The Tennessee Titans have hit the 1H Team Total Under in 12 of their last 19 games (+3.90 Units / 17% ROI)
The Tennessee Titans have hit the 4Q Moneyline in 7 of their last 17 games (+3.59 Units / 21% ROI)
The Tennessee Titans have hit the 2H Game Total Over in 4 of their last 5 away games (+2.85 Units / 47% ROI)

49ers Best Bets:

The San Francisco 49ers have hit the 1H Game Total Over in 13 of their last 20 games (+7.25 Units / 32% ROI)
The San Francisco 49ers have covered the 1Q Spread in 14 of their last 20 games (+6.95 Units / 28% ROI)
The San Francisco 49ers have hit the Game Total Over in 13 of their last 20 games (+6.40 Units / 29% ROI)
The San Francisco 49ers have hit the 3Q Game Total Over in 12 of their last 17 games (+6.05 Units / 28% ROI)
The San Francisco 49ers have hit the 1Q Moneyline in 9 of their last 19 games (+5.85 Units / 25% ROI)

Titans Against the Spread (ATS) Record

Against the spread this NFL season, the Titans are 6-7 (-1.7 Units / -11.89% ROI).

Titans are 2-11 when betting on the Moneyline for -5.95 Units / -45.77% ROI
Titans are 8-5 when betting the Over for +2.5 Units / 17.48% ROI
Titans are 5-8 when betting the Under for -3.8 Units / ROI

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 8-5 (+2.5 Units / 17.48% ROI).

49ers are 9-4 when betting on the Moneyline for +6.95 Units / 34.07% ROI
49ers are 7-5 when betting the Over for +1.5 Units / 10.49% ROI
49ers are 5-7 when betting the Under for -2.7 Units / -18.88% ROI

Tennessee Titans: Keys to the Game vs. the San Francisco 49ers

The Titans are winless (0-7) at home this season — worst in NFL; League Avg: .537.

The Titans are 1-9 (.100) when making less than 5 explosive passes in a game this season — T-worst in NFL; League Avg: .450.

The Titans are 1-11 (.083) when averaging less than 5 yards per rush this season — 2nd-worst in NFL; League Avg: .473.

The Titans are 1-9 (.100) when making less than 7 explosive plays this season — T-3rd-worst in NFL; League Avg: .422.

San Francisco 49ers: Keys to the Game vs. the Tennessee Titans

The Titans are averaging 9.4 drives per TD this season — worst Drives Per TD rate in NFL; League Avg: 4.4.

The Titans have run successful plays on 32% of plays on motion plays this season — worst in NFL; League Avg: 43%.

The Titans have averaged -0.23 epa per play on motion plays this season — worst in NFL; League Avg: 0.02.

The Titans have run successful plays on 35% of pass attempts on motion plays this season — worst in NFL; League Avg: 47%.

Additional Matchup Notes for Tennessee Titans vs. San Francisco 49ers