Seahawks vs 49ers: NFL Week 1 Odds, Prediction

The Seahawks will aim for a second straight win against the 49ers to open the 2025 season. 

Seattle won 10 games last year in Mike MacDonald’s first year. However, a tiebreaker loss to the Rams saw Seattle miss the playoffs entirely. 

San Francisco endured a 6-11 season in 2024. Myriad injuries to key players doomed San Francisco a year removed from the Super Bowl. Now, they play the league’s easiest schedule. 

Bet on Seahawks vs. 49ers and other NFL matchups with up-to-date NFL odds. 

Seahawks vs 49ers: NFL Week 1 Odds

• Date: Sunday, September 7
• Time: 4:05 p.m. ET
• Venue: Lumen Field (Seattle, WA)

Seahawks vs 49ers Prediction

Based on the Seahawks’ specific results against good offenses, my Seahawks vs. 49ers prediction focuses on the 49ers Team Total Over 23.5 Points (+100). 

I’m treating this game as a learning opportunity for the Seattle defense. If my assumption is correct, bettors can apply lessons from this game to Seattle’s remaining games. 

Last year, Seattle played markedly better defense in the second half of the year:

• Weeks 1-9: 18th in EPA/play, 22nd in success rate on plays excluding turnovers
• Weeks 11-18: 4th in EPA/play, 7th in success rate on plays excluding turnovers

But if one looks closely, the results fluctuate. Most of the latter figure stems from Weeks 12 and 17:

• Week 12 (ARI): Six Points Allowed, 5th in EPA/play, 4th in success rate (excluding turnovers)
• Week 17 (CHI): Three Points Allowed, 4th in EPA/play, 3rd in success rate (excluding turnovers)

What about the middle portion? Given Week 18 proved meaningless, that gives a decent view. 

In those four games, the Seahawks ranked 12th in EPA per play and 16th in success rate. Once again, the sample excludes turnovers. 

Most interesting about that span: Seattle played only one game against a top-five offense by DVOA. At home to Green Bay, they allowed 30 points. 

If I’m right about the 49ers, they should finish a top-five offense by DVOA this year. Last year, they exploded for 36 points in Week 6 before scoring 17 in Week 11. 

The caveat: San Francisco played without key players in both games. Christian McCaffrey missed the former while Brandon Aiyuk and George Kittle missed the latter. 

At full health, I expect San Francisco could exploit Seattle’s defense. 

Last year, Seattle played three games against teams fifth or better in offensive DVOA. All three surpassed 30 points. 

Expand the sample to teams 10th or better: 29.6 points allowed on average, only one under 25 points. 

For those reasons, the 49ers’ team total is worth a look. 

Betting Seahawks vs 49ers: NFL Public Betting

Data is reflective as of Tuesday, September 2.