Seahawks vs Cardinals Prediction, Odds & Best Prop Bets โ€“ NFL, Week 4

A detail view of an Arizona Cardinals helmet with a 9/11 decal before an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Sept. 8, 2024. (AP Photo/Adrian Kraus)
(AP Photo/Adrian Kraus)
  • The Seahawks are -1.5 point favorites vs the Cardinals
  • Total (Over/Under): 43.5 points
  • Watch this game on Amazon

The Seattle Seahawks (2-1-0) visit State Farm Stadium to take on the Arizona Cardinals (2-1-0) on Sep. 25. Kickoff is scheduled for 8:15pm EDT in Glendale, AZ.

The Seahawks are betting favorites in this matchup, with the spread sitting at -1.5 (-110).

The Seahawks vs. Cardinals Over/Under is 43.5 total points for the game.

Bet now on Cardinals vs Seahawks & all NFL games with BetMGM

Seahawks vs. Cardinals Odds, Spread, Over/Under

SpreadTotal (O/U)Moneyline
Seahawks-1.5 -11043.5 -110-125
Cardinals +1.5 -11043.5 -110105

Seahawks vs. Cardinals Prediction

The winning team model predicts the Seahawks will win this game with 70.5% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Seahawks vs Cardinals Spread Prediction

Based on recent against-the-spread trends, the model predicts the Seahawks will cover the spread with 70.5% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


Bet now on Cardinals vs Seahawks and all NFL games with BetMGM


We’ve highlighted some favorite NFL player prop bets for Seahawks players this game, looking at profitable historical betting trends:

Best Seahawks Player Prop Bets Today

  • Jaxon Smith-Njigba has hit the Receiving Yards Over in 13 of his last 17 games (+8.35 Units / 43% ROI)
  • Sam Darnold has hit the Pass Attempts Over in 7 of his last 9 away games (+4.85 Units / 46% ROI)
  • Kenneth Walker III has hit the Rushing Yards Under in 9 of his last 13 games (+4.50 Units / 31% ROI)
  • Cooper Kupp has hit the Receptions Under in 10 of his last 15 games (+4.40 Units / 24% ROI)
  • Kenneth Walker III has hit the Carries Under in 9 of his last 13 games (+4.35 Units / 28% ROI)

And here are some top NFL player prop bets for Cardinals players for this matchup, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today

  • Chad Ryland has hit the Field Goals Over in 12 of his last 16 games (+8.50 Units / 50% ROI)
  • Kyler Murray has hit the TD Passes Under in 13 of his last 17 games (+7.30 Units / 27% ROI)
  • James Conner has hit the Receptions Over in 11 of his last 16 games (+6.95 Units / 37% ROI)
  • Michael Wilson has hit the Receptions Under in 11 of his last 16 games (+6.20 Units / 33% ROI)
  • James Conner has hit the Receiving Yards Over in 11 of his last 16 games (+5.25 Units / 28% ROI)
  • The Seattle Seahawks have hit the Moneyline in 7 of their last 9 away games (+7.80 Units / 62% ROI)
  • The Seattle Seahawks have hit the 2H Moneyline in 6 of their last 8 away games (+6.35 Units / 66% ROI)
  • The Seattle Seahawks have covered the 4Q Spread in 11 of their last 17 games (+3.87 Units / 18% ROI)
  • The Seattle Seahawks have covered the 3Q Spread in 11 of their last 17 games (+3.25 Units / 14% ROI)
  • The Seattle Seahawks have hit the 4Q Moneyline in 5 of their last 8 away games (+3.19 Units / 33% ROI)
  • The Arizona Cardinals have hit the 3Q Moneyline in 11 of their last 17 games (+5.90 Units / 26% ROI)
  • The Arizona Cardinals have hit the Moneyline in 8 of their last 10 games at home (+5.39 Units / 32% ROI)
  • The Arizona Cardinals have covered the Spread in 13 of their last 20 games (+5.20 Units / 23% ROI)
  • The Arizona Cardinals have covered the 3Q Spread in 11 of their last 17 games (+4.55 Units / 22% ROI)
  • The Arizona Cardinals have covered the 1H Spread in 7 of their last 10 games at home (+4.50 Units / 38% ROI)

Seahawks Against the Spread (ATS) Record

Against the spread this NFL season, the Seahawks are 2-1 (+0.9 Units / 27.27% ROI).

  • Seahawks are 2-1 when betting on the Moneyline for +1.65 Units / 28.95% ROI
  • Seahawks are 2-1 when betting the Over for +0.9 Units / 27.27% ROI
  • Seahawks are 1-2 when betting the Under for -1.2 Units / ROI

Cardinals Against the Spread (ATS) Record

Against the spread this NFL season, the Cardinals are 2-1 (+0.9 Units / 27.27% ROI).

  • Cardinals are 2-1 when betting on the Moneyline for +1 Units / 14.39% ROI
  • Cardinals are 1-2 when betting the Over for -1.2 Units / -36.36% ROI
  • Cardinals are 2-1 when betting the Under for +0.9 Units / 27.27% ROI

Seattle Seahawks: Keys to the Game vs. the Arizona Cardinals

The Seahawks ran successful plays on 86% of plays on play action passes in Week 3 — best in NFL; League Avg: 47%.

The Seahawks have run successful plays on 71% of pass attempts in the 1st quarter this season — best in NFL; League Avg: 46%.

The Seahawks have averaged 12.7 yards per play on play action passes this season — best in NFL; League Avg: 7.3.

The Seahawks have run the ball on 52% of plays (87 carries/168 plays) this season — highest in NFL; League Avg: 41%.

Arizona Cardinals: Keys to the Game vs. the Seattle Seahawks

The Cardinals have averaged 6.3 yards per play against tight coverage this season — 2nd-best in NFL; League Avg: 2.8.

The Cardinals have targeted TEs 38% of the time (34 Pass Attempts/89 plays) this season — highest in NFL; League Avg: 21%.

The Cardinals have run successful plays on 31% of rush attempts on play action passes since the 2024 season — 3rd-worst in NFL; League Avg: 53%.

The Cardinals have run successful plays on 33% of rush attempts this season — 2nd-worst in NFL; League Avg: 43%.

Additional Matchup Notes for Seattle Seahawks vs. Arizona Cardinals

The Cardinals have averaged 6.3 yards per play against tight coverage this season — 2nd-best in NFL; League Avg: 2.8.

The Cardinals have targeted TEs 38% of the time (34 Pass Attempts/89 plays) this season — highest in NFL; League Avg: 21%.

The Cardinals have run successful plays on 31% of rush attempts on play action passes since the 2024 season — 3rd-worst in NFL; League Avg: 53%.

The Cardinals have run successful plays on 33% of rush attempts this season — 2nd-worst in NFL; League Avg: 43%.

The Seahawks ran successful plays on 86% of plays on play action passes in Week 3 — best in NFL; League Avg: 47%.

The Seahawks have run successful plays on 71% of pass attempts in the 1st quarter this season — best in NFL; League Avg: 46%.

The Seahawks have averaged 12.7 yards per play on play action passes this season — best in NFL; League Avg: 7.3.

The Seahawks have run the ball on 52% of plays (87 carries/168 plays) this season — highest in NFL; League Avg: 41%.

Seattle Seahawks Offense: Important Stats

The Seahawks ran successful plays on 86% of plays on play action passes in Week 3 — best in NFL; League Avg: 47%.

The Seahawks have run successful plays on 71% of pass attempts in the 1st quarter this season — best in NFL; League Avg: 46%.

The Seahawks have averaged 12.7 yards per play on play action passes this season — best in NFL; League Avg: 7.3.

The Seahawks have run the ball on 52% of plays (87 carries/168 plays) this season — highest in NFL; League Avg: 41%.

Arizona Cardinals Offense: Important Stats

The Cardinals have averaged 6.3 yards per play against tight coverage this season — 2nd-best in NFL; League Avg: 2.8.

The Cardinals have targeted TEs 38% of the time (34 Pass Attempts/89 plays) this season — highest in NFL; League Avg: 21%.

The Cardinals have run successful plays on 31% of rush attempts on play action passes since the 2024 season — 3rd-worst in NFL; League Avg: 53%.

The Cardinals have run successful plays on 33% of rush attempts this season — 2nd-worst in NFL; League Avg: 43%.

Seattle Seahawks Defense: Important Stats

The Seahawks ran successful plays on 86% of plays on play action passes in Week 3 — best in NFL; League Avg: 47%.

The Seahawks have run successful plays on 71% of pass attempts in the 1st quarter this season — best in NFL; League Avg: 46%.

The Seahawks have averaged 12.7 yards per play on play action passes this season — best in NFL; League Avg: 7.3.

The Seahawks have run the ball on 52% of plays (87 carries/168 plays) this season — highest in NFL; League Avg: 41%.

Arizona Cardinals Defense: Important Stats

The Cardinals have averaged 6.3 yards per play against tight coverage this season — 2nd-best in NFL; League Avg: 2.8.

The Cardinals have targeted TEs 38% of the time (34 Pass Attempts/89 plays) this season — highest in NFL; League Avg: 21%.

The Cardinals have run successful plays on 31% of rush attempts on play action passes since the 2024 season — 3rd-worst in NFL; League Avg: 53%.

The Cardinals have run successful plays on 33% of rush attempts this season — 2nd-worst in NFL; League Avg: 43%.

Looking to place a bet on this game with a First Bet Offer up to $1,500? Bet now on Cardinals vs Seahawks and all NFL games with BetMGM

More NFL Betting Predictions:

More NFL Odds at BetMGM

Take your football entertainment to the next level with NFL betting at the online sportsbook.

From futures like Chiefs Super Bowl odds, Lions odds to win the division, or Ravens playoff odds, to weekly odds like spreads, moneylines, and over/under totals, thereโ€™s something for everyone.

And with the best sportsbook promotions, you could land a welcome offer, sports betting Odds Boost, or a Parlay Boost! You can also check out NFL picks and predictions and updated Super Bowl predictions throughout the year.

Log in to your BetMGM account today โ€” or sign up for a new account via the online sportsbook or BetMGM iOS app or BetMGM Android app โ€” to start betting!

The content provided in this blog is intended for entertainment purposes only. All views and opinions expressed are the authors and reflect their individual perspectives on sports, betting, and related topics. This content should not be considered professional betting advice or the official views of BetMGM LLC. Please gamble responsibly. If you or someone you know is experiencing issues related to gambling, seek help from a licensed health professional. This blog is not liable for any losses, damages, or consequences resulting from betting activities.

About the Author Read More @BETMGM

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.