- The Seahawks are -1.5 point favorites vs the Cardinals
- Total (Over/Under): 43.5 points
- Watch this game on Amazon
The Seattle Seahawks (2-1-0) visit State Farm Stadium to take on the Arizona Cardinals (2-1-0) on Sep. 25. Kickoff is scheduled for 8:15pm EDT in Glendale, AZ.
The Seahawks are betting favorites in this matchup, with the spread sitting at -1.5 (-110).
The Seahawks vs. Cardinals Over/Under is 43.5 total points for the game.
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Seahawks vs. Cardinals Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| Seahawks | -1.5 -110 | 43.5 -110 | -125 |
| Cardinals | +1.5 -110 | 43.5 -110 | 105 |
Seahawks vs. Cardinals Prediction
The winning team model predicts the Seahawks will win this game with 70.5% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
Seahawks vs Cardinals Spread Prediction
Based on recent against-the-spread trends, the model predicts the Seahawks will cover the spread with 70.5% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
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We’ve highlighted some favorite NFL player prop bets for Seahawks players this game, looking at profitable historical betting trends:
Best Seahawks Player Prop Bets Today
- Jaxon Smith-Njigba has hit the Receiving Yards Over in 13 of his last 17 games (+8.35 Units / 43% ROI)
- Sam Darnold has hit the Pass Attempts Over in 7 of his last 9 away games (+4.85 Units / 46% ROI)
- Kenneth Walker III has hit the Rushing Yards Under in 9 of his last 13 games (+4.50 Units / 31% ROI)
- Cooper Kupp has hit the Receptions Under in 10 of his last 15 games (+4.40 Units / 24% ROI)
- Kenneth Walker III has hit the Carries Under in 9 of his last 13 games (+4.35 Units / 28% ROI)
And here are some top NFL player prop bets for Cardinals players for this matchup, looking at profitable historical betting trends:
Best Cardinals Player Prop Best Bets Today
- Chad Ryland has hit the Field Goals Over in 12 of his last 16 games (+8.50 Units / 50% ROI)
- Kyler Murray has hit the TD Passes Under in 13 of his last 17 games (+7.30 Units / 27% ROI)
- James Conner has hit the Receptions Over in 11 of his last 16 games (+6.95 Units / 37% ROI)
- Michael Wilson has hit the Receptions Under in 11 of his last 16 games (+6.20 Units / 33% ROI)
- James Conner has hit the Receiving Yards Over in 11 of his last 16 games (+5.25 Units / 28% ROI)
Seahawks Best Bets:
- The Seattle Seahawks have hit the Moneyline in 7 of their last 9 away games (+7.80 Units / 62% ROI)
- The Seattle Seahawks have hit the 2H Moneyline in 6 of their last 8 away games (+6.35 Units / 66% ROI)
- The Seattle Seahawks have covered the 4Q Spread in 11 of their last 17 games (+3.87 Units / 18% ROI)
- The Seattle Seahawks have covered the 3Q Spread in 11 of their last 17 games (+3.25 Units / 14% ROI)
- The Seattle Seahawks have hit the 4Q Moneyline in 5 of their last 8 away games (+3.19 Units / 33% ROI)
Cardinals Best Bets:
- The Arizona Cardinals have hit the 3Q Moneyline in 11 of their last 17 games (+5.90 Units / 26% ROI)
- The Arizona Cardinals have hit the Moneyline in 8 of their last 10 games at home (+5.39 Units / 32% ROI)
- The Arizona Cardinals have covered the Spread in 13 of their last 20 games (+5.20 Units / 23% ROI)
- The Arizona Cardinals have covered the 3Q Spread in 11 of their last 17 games (+4.55 Units / 22% ROI)
- The Arizona Cardinals have covered the 1H Spread in 7 of their last 10 games at home (+4.50 Units / 38% ROI)
Seahawks Against the Spread (ATS) Record
Against the spread this NFL season, the Seahawks are 2-1 (+0.9 Units / 27.27% ROI).
- Seahawks are 2-1 when betting on the Moneyline for +1.65 Units / 28.95% ROI
- Seahawks are 2-1 when betting the Over for +0.9 Units / 27.27% ROI
- Seahawks are 1-2 when betting the Under for -1.2 Units / ROI
Cardinals Against the Spread (ATS) Record
Against the spread this NFL season, the Cardinals are 2-1 (+0.9 Units / 27.27% ROI).
- Cardinals are 2-1 when betting on the Moneyline for +1 Units / 14.39% ROI
- Cardinals are 1-2 when betting the Over for -1.2 Units / -36.36% ROI
- Cardinals are 2-1 when betting the Under for +0.9 Units / 27.27% ROI
Seattle Seahawks: Keys to the Game vs. the Arizona Cardinals
The Seahawks ran successful plays on 86% of plays on play action passes in Week 3 — best in NFL; League Avg: 47%.
The Seahawks have run successful plays on 71% of pass attempts in the 1st quarter this season — best in NFL; League Avg: 46%.
The Seahawks have averaged 12.7 yards per play on play action passes this season — best in NFL; League Avg: 7.3.
The Seahawks have run the ball on 52% of plays (87 carries/168 plays) this season — highest in NFL; League Avg: 41%.
Arizona Cardinals: Keys to the Game vs. the Seattle Seahawks
The Cardinals have averaged 6.3 yards per play against tight coverage this season — 2nd-best in NFL; League Avg: 2.8.
The Cardinals have targeted TEs 38% of the time (34 Pass Attempts/89 plays) this season — highest in NFL; League Avg: 21%.
The Cardinals have run successful plays on 31% of rush attempts on play action passes since the 2024 season — 3rd-worst in NFL; League Avg: 53%.
The Cardinals have run successful plays on 33% of rush attempts this season — 2nd-worst in NFL; League Avg: 43%.
Additional Matchup Notes for Seattle Seahawks vs. Arizona Cardinals
The Cardinals have averaged 6.3 yards per play against tight coverage this season — 2nd-best in NFL; League Avg: 2.8.
The Cardinals have targeted TEs 38% of the time (34 Pass Attempts/89 plays) this season — highest in NFL; League Avg: 21%.
The Cardinals have run successful plays on 31% of rush attempts on play action passes since the 2024 season — 3rd-worst in NFL; League Avg: 53%.
The Cardinals have run successful plays on 33% of rush attempts this season — 2nd-worst in NFL; League Avg: 43%.
The Seahawks ran successful plays on 86% of plays on play action passes in Week 3 — best in NFL; League Avg: 47%.
The Seahawks have run successful plays on 71% of pass attempts in the 1st quarter this season — best in NFL; League Avg: 46%.
The Seahawks have averaged 12.7 yards per play on play action passes this season — best in NFL; League Avg: 7.3.
The Seahawks have run the ball on 52% of plays (87 carries/168 plays) this season — highest in NFL; League Avg: 41%.
Seattle Seahawks Offense: Important Stats
The Seahawks ran successful plays on 86% of plays on play action passes in Week 3 — best in NFL; League Avg: 47%.
The Seahawks have run successful plays on 71% of pass attempts in the 1st quarter this season — best in NFL; League Avg: 46%.
The Seahawks have averaged 12.7 yards per play on play action passes this season — best in NFL; League Avg: 7.3.
The Seahawks have run the ball on 52% of plays (87 carries/168 plays) this season — highest in NFL; League Avg: 41%.
Arizona Cardinals Offense: Important Stats
The Cardinals have averaged 6.3 yards per play against tight coverage this season — 2nd-best in NFL; League Avg: 2.8.
The Cardinals have targeted TEs 38% of the time (34 Pass Attempts/89 plays) this season — highest in NFL; League Avg: 21%.
The Cardinals have run successful plays on 31% of rush attempts on play action passes since the 2024 season — 3rd-worst in NFL; League Avg: 53%.
The Cardinals have run successful plays on 33% of rush attempts this season — 2nd-worst in NFL; League Avg: 43%.
Seattle Seahawks Defense: Important Stats
The Seahawks ran successful plays on 86% of plays on play action passes in Week 3 — best in NFL; League Avg: 47%.
The Seahawks have run successful plays on 71% of pass attempts in the 1st quarter this season — best in NFL; League Avg: 46%.
The Seahawks have averaged 12.7 yards per play on play action passes this season — best in NFL; League Avg: 7.3.
The Seahawks have run the ball on 52% of plays (87 carries/168 plays) this season — highest in NFL; League Avg: 41%.
Arizona Cardinals Defense: Important Stats
The Cardinals have averaged 6.3 yards per play against tight coverage this season — 2nd-best in NFL; League Avg: 2.8.
The Cardinals have targeted TEs 38% of the time (34 Pass Attempts/89 plays) this season — highest in NFL; League Avg: 21%.
The Cardinals have run successful plays on 31% of rush attempts on play action passes since the 2024 season — 3rd-worst in NFL; League Avg: 53%.
The Cardinals have run successful plays on 33% of rush attempts this season — 2nd-worst in NFL; League Avg: 43%.
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More NFL Betting Predictions:
- Anytime & First Touchdown Scorer Predictions
- Receiving Yards Prop Predictions
- Rushing Yards Prop Predictions
- Passing Yards Prop Predictions
- Receptions Made Prop Predictions
- Rushing Attempts Prop Predictions
- Passing Touchdowns Prop Predictions
- QB Interception Prop Predictions
- Field Goals Made Prop Predictions
- NFL Betting Previews: Every Game
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