Saints vs Panthers Prediction, Odds & Best Prop Bets – NFL, Week 10

BetMGM Betting Nov 07, 2025, 10:52 AM

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Fans stand for the national anthem before an NFL football game between the Carolina Panthers and the New Orleans Saints Monday, Sept. 18, 2023, in Charlotte, N.C. (AP Photo/Rusty Jones)

(AP Photo/Rusty Jones)

The Panthers are -5.5 point favorites vs the Saints
Total (Over/Under): 39.5 points
Watch this game on FOX

The New Orleans Saints (1-8-0) visit Bank of America Stadium to take on the Carolina Panthers (5-4-0) on Nov. 9. Kickoff is scheduled for 1:00pm EST in Charlotte, NC.

The Panthers are betting favorites in this matchup, with the spread sitting at -5.5 (-110).

The Saints vs. Panthers Over/Under is 39.5 total points for the game.

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Saints vs. Panthers Odds, Spread, Over/Under

	Spread	Total (O/U)	Moneyline
Saints	+5.5 -110	39.5 -110	200
Panthers	-5.5 -110	39.5 -110	-250

Saints vs. Panthers Prediction

The winning team model predicts the Panthers will win this game with 68.0% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Saints vs Panthers Spread Prediction

Based on recent against-the-spread trends, the model predicts the Saints will cover the spread with 57.0% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Saints players this game, looking at profitable historical betting trends:

Best Saints Player Prop Bets Today

Alvin Kamara has hit the Rushing Yards Under in 11 of his last 14 games (+7.55 Units / 47% ROI)
Brandin Cooks has hit the Receptions Over in 10 of his last 15 games (+5.45 Units / 31% ROI)
Alvin Kamara has hit the Receiving Yards Under in his last 5 away games (+5.00 Units / 89% ROI)
Foster Moreau has hit the Receiving Yards Over in his last 5 games (+5.00 Units / 85% ROI)
Alvin Kamara has hit the Longest Rush Under in his last 5 games (+5.00 Units / 83% ROI)

And here are some top NFL player prop bets for Panthers players for this matchup, looking at profitable historical betting trends:

Best Panthers Player Prop Best Bets Today

Rico Dowdle has hit the Rushing Yards Over in 14 of his last 18 games (+9.40 Units / 45% ROI)
Bryce Young has hit the Completions Under in 12 of his last 15 games (+8.90 Units / 51% ROI)
Rico Dowdle has hit the Carries Over in 11 of his last 15 games (+6.20 Units / 35% ROI)
Bryce Young has hit the Passing Yards Under in 11 of his last 16 games (+5.25 Units / 28% ROI)
Ja’Tavion Sanders has hit the Longest Reception Under in his last 5 games (+5.00 Units / 86% ROI)

Saints Best Bets:

The New Orleans Saints have hit the 4Q Game Total Under in 12 of their last 17 games (+6.45 Units / 32% ROI)
The New Orleans Saints have hit the 2Q Game Total Over in 11 of their last 17 games (+4.15 Units / 21% ROI)
The New Orleans Saints have hit the 3Q Game Total Under in 10 of their last 17 games (+2.05 Units / 10% ROI)
The New Orleans Saints have hit the 1H Team Total Under in 5 of their last 8 away games (+1.75 Units / 20% ROI)
The New Orleans Saints have hit the 2Q Moneyline in 7 of their last 17 games (+1.05 Units / 6% ROI)

Panthers Best Bets:

The Carolina Panthers have covered the 3Q Spread in 12 of their last 17 games (+6.60 Units / 32% ROI)
The Carolina Panthers have hit the 2H Moneyline in 8 of their last 17 games (+6.58 Units / 38% ROI)
The Carolina Panthers have hit the 2H Game Total Over in 7 of their last 8 games at home (+5.93 Units / 66% ROI)
The Carolina Panthers have hit the 3Q Moneyline in 7 of their last 17 games (+5.40 Units / 31% ROI)
The Carolina Panthers have hit the 4Q Moneyline in 6 of their last 9 games at home (+4.90 Units / 52% ROI)

Saints Against the Spread (ATS) Record

Against the spread this NFL season, the Saints are 2-7 (-5.75 Units / -57.79% ROI).

Saints are 1-8 when betting on the Moneyline for -7 Units / -74.87% ROI
Saints are 3-6 when betting the Over for -3.6 Units / -36.36% ROI
Saints are 6-3 when betting the Under for +2.7 Units / ROI

Panthers Against the Spread (ATS) Record

Against the spread this NFL season, the Panthers are 6-3 (+2.65 Units / 26.24% ROI).

Panthers are 5-4 when betting on the Moneyline for +7.15 Units / 78.57% ROI
Panthers are 5-4 when betting the Over for +0.6 Units / 6.06% ROI
Panthers are 4-5 when betting the Under for -1.5 Units / -15.15% ROI

New Orleans Saints: Keys to the Game vs. the Carolina Panthers

The Saints are winless (0-4) on the road this season — T-worst in NFL; League Avg: .446.

The Saints are winless (0-5) when having a turnover margin within one of the opposing team this season — T-worst in NFL; League Avg: .493.

The Saints are winless (0-3) when within 7 points at the two minute warning this season — T-worst in NFL; League Avg: .492.

The Saints are winless (0-6) when intercepting no passes this season — T-worst in NFL; League Avg: .340.

Carolina Panthers: Keys to the Game vs. the New Orleans Saints

The Panthers ran 64% of their plays in the red zone in the 2nd quarter in Week 9 — best in NFL; League Avg: 19%.

The Panthers have gone three and out on 4% of their drives in the 3rd quarter this season — best in NFL; League Avg: 18%.

The Panthers have run successful plays on 35% of pass attempts on passes when their QB has been pressured this season — 5th-best in NFL; League Avg: 28%.

The Panthers ran successful plays on 31% of pass attempts on first read passes in Week 9 — T-2nd-worst in NFL; League Avg: 55%.

Additional Matchup Notes for New Orleans Saints vs. Carolina Panthers