Rams vs. Colts: NFL Week 4 Odds, Prediction

See the latest NFL Week 4 odds, picks and predictions for Rams vs. Colts on September 28 at SoFi Stadium in Los Angeles.
  • The Rams are a 3.5-point home favorite against the Colts.
  • The Rams have won each of their last 12 Sunday games as favorites.
  • My Rams vs Colts prediction is the Los Angeles Rams Over 26.5 Points (-130).

After surrendering a massive lead to the Eagles, the Rams return home to face the 3-0 Colts. 

Los Angeles led 26-7 in Philadelphia. However, a weak second half saw Philadelphia overcome the deficit in a 33-26 win over Sean McVay’s side. 

The Colts jumped to 3-0 SU & ATS with a win over the Titans as road favorites. In each of those three games, Shane Steichen’s team scored at least 29 points. 

Bet on Rams vs. Colts and other NFL matchups with up-to-date NFL odds. 

Rams vs. Colts: NFL Week 4 Odds

Rams vs. Colts Prediction

Monday, September 22

Based on the Rams’ offensive success and the Colts’ lack of experience against quality offenses, my Rams vs Colts prediction is the Rams Team Total Over 26.5 Points (-130). 

The Rams finished just under this figure in Philadelphia. Back in Week 2, Los Angeles scored 33 points against the Titans. 

For Indianapolis, Week 4 easily qualifies as the toughest test for the defense. 

They’ve now played three games, all of which came against teams 20th or worse in EPA per play and success rate. 

Through three weeks, the Rams rank sixth in both offensive categories. The Rams also sit fourth in offensive DVOA, while Denver, Miami and Tennessee all sit 18th or worse. 

Denver qualifies as the best of those three opponents for Indy. 

In that game, the Broncos managed 28 points against the Colts defense, which has played the fourth-easiest set of offenses, per ftnfantasy.com. 

Based on those factors, I’ll sell this version of the Colts defense against a powerful Rams offense. 

However, I’ll wait to confirm the team total and price before making a final prediction for Sunday. 

Betting Rams vs. Colts: NFL Public Betting

Team% of ATS Bets% of ATS Money% of ML Bets% of ML Money
Colts31%63%64%22%
Rams69%37%36%78%

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About the Author Read More @nickhennion

Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.

Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.