Rams vs Panthers Prediction, Odds & Best Prop Bets – NFL, Week 13

BetMGM Betting Nov 30, 2025, 9:56 AM

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Fans stand for the national anthem before an NFL football game between the Carolina Panthers and the New Orleans Saints Monday, Sept. 18, 2023, in Charlotte, N.C. (AP Photo/Rusty Jones)

(AP Photo/Rusty Jones)

The Rams are -10 point favorites vs the Panthers
Total (Over/Under): 45 points
Watch this game on FOX

The Los Angeles Rams (9-2-0) visit Bank of America Stadium to take on the Carolina Panthers (6-6-0) on Nov. 30. Kickoff is scheduled for 1:00pm EST in Charlotte, NC.

The Rams are betting favorites in this matchup, with the spread sitting at -10 (-110).

The Rams vs. Panthers Over/Under is 45 total points for the game.

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Rams vs. Panthers Odds, Spread, Over/Under

	Spread	Total (O/U)	Moneyline
Rams	-10 -110	45 -110	-650
Panthers	+10 -110	45 -110	475

Rams vs. Panthers Prediction

The winning team model predicts the Rams will win this game with 78.4% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Rams vs Panthers Spread Prediction

Based on recent against-the-spread trends, the model predicts the Panthers will cover the spread with 50.3% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Rams players this game, looking at profitable historical betting trends:

Best Panthers Player Prop Bets Today

Bryce Young has hit the Completions Under in 13 of his last 16 games (+9.85 Units / 53% ROI)
Bryce Young has hit the Passing Yards Under in 12 of his last 17 games (+6.25 Units / 32% ROI)
Ja’Tavion Sanders has hit the Longest Reception Under in 7 of his last 8 games (+5.95 Units / 66% ROI)
Bryce Young has hit the Longest Rush Under in 8 of his last 10 games (+5.75 Units / 51% ROI)
Chuba Hubbard has hit the Rushing Yards Under in 10 of his last 14 games (+5.45 Units / 35% ROI)

And here are some top NFL player prop bets for Panthers players for this matchup, looking at profitable historical betting trends:

Best Rams Player Prop Best Bets Today

Matthew Stafford has hit the Interceptions Under in 15 of his last 18 games (+11.50 Units / 53% ROI)
Blake Corum has hit the Receiving Yards Under in his last 6 games (+6.00 Units / 87% ROI)
Matthew Stafford has hit the TD Passes Over in 12 of his last 18 games (+6.00 Units / 27% ROI)
Kyren Williams has hit the Receptions Under in 7 of his last 9 away games (+5.85 Units / 53% ROI)
Matthew Stafford has hit the Pass Attempts Under in 12 of his last 18 games (+5.35 Units / 26% ROI)

Panthers Best Bets:

The Carolina Panthers have hit the 3Q Moneyline in 8 of their last 18 games (+6.55 Units / 35% ROI)
The Carolina Panthers have hit the 2Q Game Total Over in 11 of their last 18 games (+4.50 Units / 24% ROI)
The Carolina Panthers have covered the 3Q Spread in 12 of their last 18 games (+4.50 Units / 22% ROI)
The Carolina Panthers have hit the 2H Moneyline in 8 of their last 18 games (+3.93 Units / 21% ROI)
The Carolina Panthers have hit the Game Total Over in 7 of their last 10 games at home (+3.70 Units / 34% ROI)

Rams Best Bets:

The Los Angeles Rams have covered the Spread in 18 of their last 22 games (+13.50 Units / 56% ROI)
The Los Angeles Rams have hit the Moneyline in 17 of their last 22 games (+11.90 Units / 24% ROI)
The Los Angeles Rams have hit the 4Q Moneyline in 11 of their last 19 games (+8.50 Units / 30% ROI)
The Los Angeles Rams have hit the 2Q Moneyline in 13 of their last 19 games (+7.50 Units / 25% ROI)
The Los Angeles Rams have covered the 2Q Spread in 13 of their last 19 games (+6.35 Units / 29% ROI)

Rams Against the Spread (ATS) Record

Against the spread this NFL season, the Rams are 8-3 (+4.6 Units / 37.7% ROI).

Rams are 9-2 when betting on the Moneyline for +3.6 Units / 10.33% ROI
Rams are 4-7 when betting the Over for -3.7 Units / -30.58% ROI
Rams are 7-4 when betting the Under for +2.6 Units / ROI

Panthers Against the Spread (ATS) Record

Against the spread this NFL season, the Panthers are 7-5 (+2.55 Units / 20.73% ROI).

Panthers are 6-6 when betting on the Moneyline for +6.6 Units / 52.8% ROI
Panthers are 6-6 when betting the Over for +0.5 Units / 4.13% ROI
Panthers are 6-6 when betting the Under for -1.6 Units / -13.22% ROI

Los Angeles Rams: Keys to the Game vs. the Carolina Panthers

The Panthers have gone three and out on 3% of their drives in the 3rd quarter this season — best in NFL; League Avg: 19%.

The Panthers ran 42% of their plays in the red zone in the 1st half in Week 12 — best in NFL; League Avg: 14%.

The Panthers have gone three and out 6 times in the 2nd quarter since Week 9 — T-most in NFL.

The Panthers had a third down conversion rate of 14% in Week 12 — worst in NFL; League Avg: 36%.

Carolina Panthers: Keys to the Game vs. the Los Angeles Rams

The Panthers defense has allowed a third down conversion rate of 39% on 3rd and long this season — 2nd-worst in NFL; League Avg: 24%.

The Panthers defense has allowed a passer rating of 124.9 on 3rd and long (56 Pass Attempts) this season — worst in NFL; League Avg: 82.9.

The Panthers defense has allowed successful plays on 38% of pass attempts against play action passes this season — 2nd-best in NFL; League Avg: 52%.

The Panthers have been flagged 14 times on Defense this season — fewest in NFL.

Additional Matchup Notes for Los Angeles Rams vs. Carolina Panthers