- The Cardinals are -6.5 point favorites vs the Panthers
- Total (Over/Under): 44.5 points
- Watch this game on CBS
The Carolina Panthers (0-1-0) visit State Farm Stadium to take on the Arizona Cardinals (1-0-0) on Sep. 14. Kickoff is scheduled for 4:05pm EDT in Glendale, AZ.
The Cardinals are betting favorites in this matchup, with the spread sitting at -6.5 (-115).
The Panthers vs. Cardinals Over/Under is 44.5 total points for the game.
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Panthers vs. Cardinals Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| Panthers | ++6.5 -105 | 44.5 -110 | 240 |
| Cardinals | -6.5 -115 | 44.5 -110 | -300 |
Panthers vs. Cardinals Prediction
The winning team model predicts the Cardinals will win this game with 75.1% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
Panthers vs Cardinals Spread Prediction
Based on recent against-the-spread trends, the model predicts the Panthers will cover the spread with 53.4% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
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We’ve highlighted some favorite NFL player prop bets for Panthers players this game, looking at profitable historical betting trends:
Best Panthers Player Prop Bets Today
- Bryce Young has hit the TD Passes Over in 8 of his last 10 games (+7.55 Units / 56% ROI)
- Rico Dowdle has hit the Rushing Yards Over in 11 of his last 14 games (+7.55 Units / 46% ROI)
- Rico Dowdle has hit the Carries Over in his last 6 away games (+6.00 Units / 79% ROI)
- Eddy Pineiro has hit the Field Goals Under in his last 6 away games (+6.00 Units / 72% ROI)
- Chuba Hubbard has hit the Rushing Yards Over in 10 of his last 14 games (+5.30 Units / 33% ROI)
And here are some top NFL player prop bets for Cardinals players for this matchup, looking at profitable historical betting trends:
Best Cardinals Player Prop Best Bets Today
- James Conner has hit the Receptions Over in 9 of his last 11 games (+8.05 Units / 59% ROI)
- Kyler Murray has hit the TD Passes Under in 12 of his last 15 games (+7.70 Units / 32% ROI)
- Trey McBride has hit the Receiving Yards Over in 10 of his last 13 games (+6.45 Units / 42% ROI)
- Kyler Murray has hit the Completions Over in 7 of his last 8 games (+5.70 Units / 60% ROI)
- James Conner has hit the Receiving Yards Over in 9 of his last 12 games (+5.55 Units / 40% ROI)
Panthers Best Bets:
- The Carolina Panthers have hit the 2Q Game Total Over in 14 of their last 16 games (+11.90 Units / 66% ROI)
- The Carolina Panthers have hit the 1H Game Total Over in 14 of their last 18 games (+10.55 Units / 51% ROI)
- The Carolina Panthers have hit the Game Total Over in 13 of their last 20 games (+5.30 Units / 24% ROI)
- The Carolina Panthers have covered the 3Q Spread in 7 of their last 9 games (+4.95 Units / 49% ROI)
- The Carolina Panthers have hit the 2H Game Total Over in 7 of their last 9 games (+4.78 Units / 48% ROI)
Cardinals Best Bets:
- The Arizona Cardinals have covered the 2H Spread in 8 of their last 9 games at home (+7.38 Units / 71% ROI)
- The Arizona Cardinals have hit the 2H Moneyline in their last 5 games (+5.60 Units / 77% ROI)
- The Arizona Cardinals have covered the Spread in 13 of their last 20 games (+5.10 Units / 23% ROI)
- The Arizona Cardinals have hit the 1H Game Total Over in 7 of their last 10 games at home (+4.75 Units / 40% ROI)
- The Arizona Cardinals have hit the 3Q Moneyline in 7 of their last 10 games (+4.70 Units / 36% ROI)
Panthers Against the Spread (ATS) Record
Against the spread this NFL season, the Panthers are 0-1 (-1.1 Units / -100% ROI).
- Panthers are 0-1 when betting on the Moneyline for -1 Units / -100% ROI
- Panthers are 0-1 when betting the Over for -1.1 Units / -100% ROI
- Panthers are 1-0 when betting the Under for +1 Units / ROI
Cardinals Against the Spread (ATS) Record
Against the spread this NFL season, the Cardinals are 1-0 (+1 Units / 90.91% ROI).
- Cardinals are 1-0 when betting on the Moneyline for +1 Units / 37.74% ROI
- Cardinals are 0-1 when betting the Over for -1.1 Units / -100% ROI
- Cardinals are 1-0 when betting the Under for +1 Units / 90.91% ROI
Carolina Panthers: Keys to the Game vs. the Arizona Cardinals
The Panthers were winless (0-6) when converting less than 55% of its red zone chances into touchdowns last season — worst in NFL; League Avg: .401.
The Panthers are 3-6 (.333) when rushing more than 30 times since the 2023 season — worst in NFL; League Avg: .742.
The Panthers were winless (0-5) vs top 10 offenses last season — T-worst in NFL; League Avg: .318.
The Panthers are 2-7 (.222) when sacking the QB 3 or more times since the 2023 season — worst in NFL; League Avg: .650.
Arizona Cardinals: Keys to the Game vs. the Carolina Panthers
The Cardinals were winless (0-6) when the opposing team rushes more than 30 times last season — T-worst in NFL; League Avg: .249.
The Cardinals were winless (0-6) when committing 60 or more yards in penalties last season — T-worst in NFL; League Avg: .440.
The Cardinals were winless (0-4) vs top 10 run offenses last season — T-worst in NFL; League Avg: .335.
The Cardinals were 6-3 (.667) at home last season — T-9th-best in NFL; League Avg: .524.
Additional Matchup Notes for Carolina Panthers vs. Arizona Cardinals
The Cardinals were successful on 47.8% of plays they ran with motion last season — 5th-best in NFL. The Panthers allowed a success rate of 47.5% against motion last season — 3rd-worst in NFL.
The Cardinals were successful on 51.0% of pass attempts last season — 5th-best in NFL. The Panthers allowed a success rate of 49.1% on pass attempts last season — 5th-worst in NFL.
The Cardinals were successful on 51.0% of pass attempts on their opponent’s side of the field last season — 3rd-best in NFL. The Panthers allowed a success rate of 51.7% on pass attempts on their own side of the field last season — 5th-worst in NFL.
Panthers WRs averaged just 0.9 yards after the catch last week — worst in NFL. The Cardinals allowed just 2.4 yards after catch per reception to WRs last week — 5th-best in NFL.
The Panthers were successful on just 32.6% of plays they ran against a stacked front last season — 2nd-worst in NFL. The Cardinals allowed a success rate of just 33.3% with a stacked front last season — best in NFL.
Carolina Panthers Offense: Important Stats
The Panthers went three and out 10 times in the 2nd quarter in the last 4 weeks of the regular season — most in NFL.
The Panthers averaged -0.41 epa per play on the road in the last 4 weeks of the regular season — worst in NFL; League Avg: -0.04.
The Panthers went three and out 19 times in the 2nd quarter last season — most in NFL.
The Panthers ran successful plays on 40% of pass attempts last season — T-2nd-worst in NFL; League Avg: 46%.
Arizona Cardinals Offense: Important Stats
The Cardinals converted late downs on just 6 of 198 plays (3%) with 7-10 yards to go last season — worst in NFL; League Avg: 6%.
The Cardinals started 9 drives inside opposing territory last season — 3rd-fewest in NFL.
The Cardinals had 8 rushes of 20+ yards in the last 4 weeks of the regular season — most in NFL.
The Cardinals had a third down conversion rate of 11% on third and 10+ yards to go last season — 3rd-worst in NFL; League Avg: 18%.
Carolina Panthers Defense: Important Stats
The Panthers defense allowed 181.3 rushing yards per game (3,082/17) last season — worst in NFL; League Avg: 120.7.
The Panthers defense allowed 0.62 epa per play open coverage last season — worst in NFL; League Avg: 0.42.
The Panthers defense allowed 417.6 yards from scrimmage per game last season — worst in NFL; League Avg: 353.3.
The Panthers defense allowed 182.2 yards from scrimmage per game to RBs last season — worst in NFL; League Avg: 126.8.
Arizona Cardinals Defense: Important Stats
The Cardinals defense allowed successful plays on 57% of pass attempts from their own territory last season — worst in NFL; League Avg: 48%.
The Cardinals defense allowed successful plays on 59% of pass attempts in the 1st quarter last season — worst in NFL; League Avg: 48%.
The Cardinals defense has allowed successful plays on 49% of plays in the 1st half since the 2023 season — worst in NFL; League Avg: 43%.
The Cardinals defense allowed an average of 2.6 yards after contact per carry (382 carries) to RBs last season — worst in NFL; League Avg: 2.1.
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More NFL Betting Predictions:
- Anytime & First Touchdown Scorer Predictions
- Receiving Yards Prop Predictions
- Rushing Yards Prop Predictions
- Passing Yards Prop Predictions
- Receptions Made Prop Predictions
- Rushing Attempts Prop Predictions
- Passing Touchdowns Prop Predictions
- QB Interception Prop Predictions
- Field Goals Made Prop Predictions
- NFL Betting Previews: Every Game
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