Panthers vs 49ers Prediction, Odds & Best Prop Bets – NFL, Week 12

BetMGM Betting Nov 19, 2025, 11:59 AM

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An exterior of Levi's Stadium is shown before an NFL preseason football game between the San Francisco 49ers and the Los Angeles Chargers in Santa Clara, Calif., Thursday, Aug. 29, 2019. (AP Photo/Tony Avelar)

(AP Photo/Tony Avelar)

The 49ers are-7 point favorites vs the Panthers
Total (Over/Under): 49 points
Watch this game on ESPN | ESPD

The Carolina Panthers (6-5-0) visit Levi’s Stadium to take on the San Francisco 49ers (7-4-0) on Nov. 24. Kickoff is scheduled for 8:15pm EST in Santa Clara, CA.

The 49ers are betting favorites in this matchup, with the spread sitting at -7 (-110).

The Panthers vs. 49ers Over/Under is 49 total points for the game.

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Panthers vs. 49ers Odds, Spread, Over/Under

	Spread	Total (O/U)	Moneyline
Panthers	+7 -110	49 -110	275
49ers	-7 -110	49 -110	-350

Panthers vs. 49ers Prediction

The winning team model predicts the 49ers will win this game with 61.1% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Panthers vs 49ers Spread Prediction

Based on recent against-the-spread trends, the model predicts the Panthers will cover the spread with 56.3% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Panthers players this game, looking at profitable historical betting trends:

Best Panthers Player Prop Bets Today

Bryce Young has hit the Completions Under in 12 of his last 16 games (+7.75 Units / 42% ROI)
Rico Dowdle has hit the Rushing Yards Over in 13 of his last 18 games (+7.20 Units / 34% ROI)
Bryce Young has hit the Longest Rush Under in 8 of his last 9 games (+6.90 Units / 68% ROI)
Rico Dowdle has hit the Carries Over in 11 of his last 15 games (+6.50 Units / 37% ROI)
Bryce Young has hit the Carries Under in 11 of his last 16 games (+5.40 Units / 26% ROI)

And here are some top NFL player prop bets for 49ers players for this matchup, looking at profitable historical betting trends:

Best 49ers Player Prop Best Bets Today

Christian McCaffrey has hit the Longest Rush Under in 9 of his last 11 games (+6.70 Units / 52% ROI)
Christian McCaffrey has hit the Receiving Yards Over in 10 of his last 13 games (+6.50 Units / 43% ROI)
Kendrick Bourne has hit the Longest Reception Over in 6 of his last 7 games (+4.85 Units / 58% ROI)
Christian McCaffrey has hit the Longest Reception Over in 7 of his last 9 games (+4.85 Units / 48% ROI)
Brian Robinson has hit the Receptions Under in 9 of his last 13 games (+4.80 Units / 28% ROI)

Panthers Best Bets:

The Carolina Panthers have hit the 2H Moneyline in 9 of their last 18 games (+6.78 Units / 35% ROI)
The Carolina Panthers have hit the 3Q Moneyline in 8 of their last 18 games (+6.55 Units / 34% ROI)
The Carolina Panthers have hit the Moneyline in 4 of their last 10 away games (+5.95 Units / 59% ROI)
The Carolina Panthers have hit the 2Q Game Total Over in 12 of their last 18 games (+5.55 Units / 28% ROI)
The Carolina Panthers have covered the 3Q Spread in 12 of their last 18 games (+5.55 Units / 25% ROI)

49ers Best Bets:

The San Francisco 49ers have hit the 1H Game Total Over in 15 of their last 21 games (+10.30 Units / 42% ROI)
The San Francisco 49ers have hit the Game Total Over in 15 of their last 21 games (+9.50 Units / 41% ROI)
The San Francisco 49ers have covered the 1Q Spread in 7 of their last 9 games at home (+4.95 Units / 45% ROI)
The San Francisco 49ers have hit the 3Q Game Total Over in 12 of their last 18 games (+4.85 Units / 22% ROI)
The San Francisco 49ers have hit the 2Q Game Total Over in 11 of their last 18 games (+3.45 Units / 17% ROI)

Panthers Against the Spread (ATS) Record

Against the spread this NFL season, the Panthers are 7-4 (+2.55 Units / 20.73% ROI).

Panthers are 6-5 when betting on the Moneyline for +6.6 Units / 52.8% ROI
Panthers are 6-5 when betting the Over for +0.5 Units / 4.13% ROI
Panthers are 5-6 when betting the Under for -1.6 Units / ROI

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 6-5 (+0.5 Units / 4.13% ROI).

49ers are 7-4 when betting on the Moneyline for +4.95 Units / 34.98% ROI
49ers are 7-3 when betting the Over for +3.7 Units / 30.58% ROI
49ers are 3-7 when betting the Under for -4.7 Units / -38.84% ROI

Carolina Panthers: Keys to the Game vs. the San Francisco 49ers

The 49ers defense has averaged a sack every 34.0 pass attempts (408 Pass Attempts/12 Sacks) this season — worst attempts per sack rate in NFL; League Avg: 14.7.

The 49ers defense has allowed a passer rating of 129.2 when blitzing (74 Pass Attempts) this season — worst in NFL; League Avg: 92.6.

The 49ers defense has allowed successful plays on 79% of plays with a stacked front this season — 3rd-worst in NFL; League Avg: 46%.

The 49ers defense allowed 47 completions in Week 11 — most in NFL.

San Francisco 49ers: Keys to the Game vs. the Carolina Panthers

The 49ers have targeted RBs 27% of the time (104 Pass Attempts/388 plays) this season — highest in NFL; League Avg: 17%.

The 49ers started 4 drives inside opposing territory in Week 11 — most in NFL.

The 49ers have run 59% of their plays in their opponent’s territory in the 2nd half this season — 2nd-best in NFL; League Avg: 49%.

The 49ers ran 96% of their plays in their opponent’s territory in the 2nd half in Week 11 — best in NFL; League Avg: 49%.

Additional Matchup Notes for Carolina Panthers vs. San Francisco 49ers