Jaguars vs 49ers Prediction, Odds & Best Prop Bets – NFL, Week 4

• The 49ers are -3 point favorites vs the Jaguars
• Total (Over/Under): 47 points
• Watch this game on FOX

The Jacksonville Jaguars (2-1-0) visit Levi’s Stadium to take on the San Francisco 49ers (3-0-0) on Sep. 28. Kickoff is scheduled for 4:05pm EDT in Santa Clara, CA.

The 49ers are betting favorites in this matchup, with the spread sitting at-3.

The Jaguars vs. 49ers Over/Under is 47 total points for the game.

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Jaguars vs. 49ers Odds, Spread, Over/Under

Jaguars vs. 49ers Prediction

The winning team model predicts the 49ers will win this game with 69.7% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Jaguars vs 49ers Spread Prediction

Based on recent against-the-spread trends, the model predicts the Jaguars will cover the spread with 69.7% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Jaguars players this game, looking at profitable historical betting trends:

Best Jaguars Player Prop Bets Today

• Travis Etienne has hit the Rushing Yards Under in 7 of his last 8 away games (+5.85 Units / 64% ROI)
• Trevor Lawrence has hit the Rushing Yards Under in 8 of his last 10 games (+5.75 Units / 50% ROI)
• Dyami Brown has hit the Receiving Yards Over in 9 of his last 12 games (+5.50 Units / 39% ROI)
• Trevor Lawrence has hit the Interceptions Over in 8 of his last 10 games (+5.30 Units / 40% ROI)
• Tim Patrick has hit the Receptions Over in 7 of his last 9 games (+5.20 Units / 46% ROI)

And here are some top NFL player prop bets for 49ers players for this matchup, looking at profitable historical betting trends:

Best 49ers Player Prop Best Bets Today

• Demarcus Robinson has hit the Receptions Under in 13 of his last 15 games (+10.30 Units / 49% ROI)
• Brian Robinson has hit the Receptions Under in 7 of his last 8 games at home (+6.80 Units / 67% ROI)
• Brock Purdy has hit the Carries Over in 10 of his last 13 games (+6.65 Units / 42% ROI)
• Christian McCaffrey has hit the Rushing Yards Under in 6 of his last 7 games (+4.85 Units / 61% ROI)
• Brock Purdy has hit the Rushing Yards Over in 9 of his last 13 games (+4.40 Units / 30% ROI)

Jaguars Best Bets:

• The Jacksonville Jaguars have covered the 1Q Spread in 13 of their last 20 games (+5.75 Units / 23% ROI)
• The Jacksonville Jaguars have hit the 4Q Game Total Under in 6 of their last 8 away games (+4.95 Units / 54% ROI)
• The Jacksonville Jaguars have hit the 3Q Game Total Under in 10 of their last 17 games (+2.35 Units / 12% ROI)
• The Jacksonville Jaguars have hit the 2H Moneyline in 4 of their last 8 away games (+2.11 Units / 26% ROI)
• The Jacksonville Jaguars have covered the 2H Spread in 5 of their last 8 away games (+1.82 Units / 20% ROI)

49ers Best Bets:

• The San Francisco 49ers have covered the 1Q Spread in 15 of their last 20 games (+10.85 Units / 47% ROI)
• The San Francisco 49ers have hit the 1Q Moneyline in 12 of their last 19 games (+9.10 Units / 34% ROI)
• The San Francisco 49ers have hit the 2H Game Total Over in 12 of their last 16 games (+7.51 Units / 42% ROI)
• The San Francisco 49ers have hit the 4Q Game Total Over in 12 of their last 17 games (+7.25 Units / 38% ROI)
• The San Francisco 49ers have hit the Game Total Over in 12 of their last 20 games (+3.20 Units / 15% ROI)

Jaguars Against the Spread (ATS) Record

Against the spread this NFL season, the Jaguars are 2-1 (+0.9 Units / 27.27% ROI).

• Jaguars are 2-1 when betting on the Moneyline for +1 Units / 22.73% ROI
• Jaguars are 1-2 when betting the Over for -1.2 Units / -36.36% ROI
• Jaguars are 2-1 when betting the Under for +0.9 Units / ROI

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 2-1 (+0.9 Units / 27.27% ROI).

• 49ers are 3-0 when betting on the Moneyline for +3 Units / 72.29% ROI
• 49ers are 1-2 when betting the Over for -1.2 Units / -36.36% ROI
• 49ers are 2-1 when betting the Under for +0.9 Units / 27.27% ROI

Jacksonville Jaguars: Keys to the Game vs. the San Francisco 49ers

San Francisco 49ers: Keys to the Game vs. the Jacksonville Jaguars

Additional Matchup Notes for Jacksonville Jaguars vs. San Francisco 49ers

Jacksonville Jaguars Offense: Important Stats

San Francisco 49ers Offense: Important Stats

Jacksonville Jaguars Defense: Important Stats

San Francisco 49ers Defense: Important Stats

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More NFL Betting Predictions:

• Anytime & First Touchdown Scorer Predictions
• Receiving Yards Prop Predictions
• Rushing Yards Prop Predictions
• Passing Yards Prop Predictions
• Receptions Made Prop Predictions
• Rushing Attempts Prop Predictions
• Passing Touchdowns Prop Predictions
• QB Interception Prop Predictions
• Field Goals Made Prop Predictions
• NFL Betting Previews: Every Game

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