Giants vs Saints Prediction, Odds & Best Prop Bets – NFL, Week 5

BetMGM Betting Oct 01, 2025, 11:09 AM

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A New Orleans Saints helmet sits on the turf prior to an NFL football game against the Carolina Panthers, Monday, Sep. 18, 2023, in Charlotte, N.C. (AP Photo/Brian Westerholt)

(AP Photo/Brian Westerholt)

The Giants are +2 point favorites vs the Saints
Total (Over/Under): 41 points
Watch this game on CBS

The New York Giants (1-3-0) visit Caesars Superdome to take on the New Orleans Saints (0-4-0) on Oct. 5. Kickoff is scheduled for 1:00pm EDT in New Orleans, LA.

The Giants are betting favorites in this matchup, with the spread sitting at +2 (-110).

The Giants vs. Saints Over/Under is 41 total points for the game.

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Giants vs. Saints Odds, Spread, Over/Under

	Spread	Total (O/U)	Moneyline
Giants	+2 -110	41 -110	110
Saints	-2 -110	41 -110	-135

Giants vs. Saints Prediction

The winning team model predicts the Giants will win this game with 70.7% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Giants vs Saints Spread Prediction

Based on recent against-the-spread trends, the model predicts the Giants will cover the spread with 68.5% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Giants players this game, looking at profitable historical betting trends:

Best Giants Player Prop Bets Today

Theo Johnson has hit the Receptions Over in 9 of his last 11 games (+8.00 Units / 65% ROI)
Theo Johnson has hit the Receiving Yards Over in 8 of his last 11 games (+4.50 Units / 36% ROI)
Darius Slayton has hit the Receptions Under in 10 of his last 15 games (+4.25 Units / 20% ROI)
Wan’Dale Robinson has hit the Receptions Over in 6 of his last 8 away games (+4.00 Units / 36% ROI)
Devin Singletary has hit the Carries Under in 5 of his last 7 games (+2.75 Units / 34% ROI)

And here are some top NFL player prop bets for Saints players for this matchup, looking at profitable historical betting trends:

Best Saints Player Prop Best Bets Today

Juwan Johnson has hit the Receiving Yards Over in 12 of his last 17 games (+6.30 Units / 32% ROI)
Brandin Cooks has hit the Receptions Over in 8 of his last 10 games (+6.15 Units / 49% ROI)
Juwan Johnson has hit the Receptions Over in 12 of his last 17 games (+6.15 Units / 28% ROI)
Spencer Rattler has hit the Completions Over in his last 5 games at home (+5.00 Units / 89% ROI)
Spencer Rattler has hit the Pass Attempts Over in his last 5 games at home (+5.00 Units / 87% ROI)

Giants Best Bets:

The New York Giants have hit the 4Q Moneyline in 8 of their last 17 games (+4.12 Units / 23% ROI)
The New York Giants have covered the 4Q Spread in 11 of their last 17 games (+3.80 Units / 18% ROI)
The New York Giants have hit the 2H Game Total Over in 5 of their last 7 away games (+2.85 Units / 38% ROI)
The New York Giants have hit the 1H Team Total Over in 6 of their last 9 away games (+2.40 Units / 21% ROI)
The New York Giants have hit the 4Q Game Total Under in 10 of their last 17 games (+1.85 Units / 9% ROI)

Saints Best Bets:

The New Orleans Saints have hit the 2Q Game Total Over in 11 of their last 17 games (+3.95 Units / 20% ROI)
The New Orleans Saints have hit the 1H Team Total Under in 12 of their last 20 games (+3.90 Units / 17% ROI)
The New Orleans Saints have hit the 4Q Game Total Over in 6 of their last 9 games at home (+2.85 Units / 28% ROI)
The New Orleans Saints have hit the 2H Game Total Over in 6 of their last 9 games at home (+2.72 Units / 27% ROI)
The New Orleans Saints have hit the 1H Game Total Over in 7 of their last 11 games at home (+2.25 Units / 18% ROI)

Giants Against the Spread (ATS) Record

Against the spread this NFL season, the Giants are 2-2 (-0.2 Units / -4.55% ROI).

Giants are 1-3 when betting on the Moneyline for -0.7 Units / -17.5% ROI
Giants are 1-3 when betting the Over for -2.3 Units / -52.27% ROI
Giants are 3-1 when betting the Under for +1.9 Units / ROI

Saints Against the Spread (ATS) Record

Against the spread this NFL season, the Saints are 1-3 (-2.3 Units / -52.27% ROI).

Saints are 0-4 when betting on the Moneyline for -4 Units / -100% ROI
Saints are 3-1 when betting the Over for +1.9 Units / 43.18% ROI
Saints are 1-3 when betting the Under for -2.3 Units / -52.27% ROI

New York Giants: Keys to the Game vs. the New Orleans Saints

The Giants are 2-7 (.222) when sacking the QB 3 or more times since the 2024 season — worst in NFL; League Avg: .648.

The Giants are 1-3 (.250) this season — T-4th-worst in NFL; League Avg: .492.

The Giants are winless (0-14) whe trailing at the end of the first half since the 2024 season — T-worst in NFL; League Avg: .241.

The Giants are 2-15 (.118) when committing 1 or more turnovers since the 2024 season — worst in NFL; League Avg: .399.

New Orleans Saints: Keys to the Game vs. the New York Giants

The Saints defense has allowed successful plays on 60% of rush attempts in the 3rd quarter since the 2024 season — worst in NFL; League Avg: 44%.

The Saints defense have allowed 0.27 epa per play in the 1st half this season — 2nd-worst in NFL; League Avg: 0.03.

The Saints defense has allowed 6.6 yards after the catch (655 RAC / 100 receptions) to TEs since the 2024 season — worst in NFL; League Avg: 4.8.

The Saints defense has allowed a passer rating of 132.4 on motion plays (70 Pass Attempts) this season — worst in NFL; League Avg: 97.1.

Additional Matchup Notes for New York Giants vs. New Orleans Saints