Falcons vs Cardinals Prediction, Odds & Best Prop Bets โ€“ NFL, Week 16

A detail view of an Arizona Cardinals helmet with a 9/11 decal before an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Sept. 8, 2024. (AP Photo/Adrian Kraus)
(AP Photo/Adrian Kraus)
  • The Falcons are -2.5 point favorites vs the Cardinals
  • Total (Over/Under): 47.5 points
  • Watch this game on FOX

The Atlanta Falcons (5-9-0) visit State Farm Stadium to take on the Arizona Cardinals (3-11-0) on Dec. 21. Kickoff is scheduled for 4:05pm EST in Glendale, AZ.

The Falcons are betting favorites in this matchup, with the spread sitting at -2.5 (-110).

The Falcons vs. Cardinals Over/Under is 47.5 total points for the game.

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Falcons vs. Cardinals Odds, Spread, Over/Under

Falcons vs. Cardinals Prediction

The winning team model predicts the Falcons will win this game with 56.8% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Falcons vs Cardinals Spread Prediction

Based on recent against-the-spread trends, the model predicts the Cardinals will cover the spread with 54.3% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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We’ve highlighted some favorite NFL player prop bets for Falcons players this game, looking at profitable historical betting trends:

Best Falcons Player Prop Bets Today

  • Kyle Pitts has hit the Longest Reception Over in 8 of his last 9 games (+6.85 Units / 66% ROI)
  • Darnell Mooney has hit the Receptions Under in 10 of his last 15 games (+5.15 Units / 30% ROI)
  • Drake London has hit the Receptions Over in 9 of his last 13 games (+4.45 Units / 29% ROI)
  • Darnell Mooney has hit the Receiving Yards Under in 10 of his last 15 games (+4.40 Units / 26% ROI)
  • Kyle Pitts has hit the Receptions Over in 7 of his last 10 away games (+3.95 Units / 34% ROI)

And here are some top NFL player prop bets for Cardinals players for this matchup, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today

  • Jacoby Brissett has hit the TD Passes Over in 8 of his last 9 games (+9.60 Units / 96% ROI)
  • Jacoby Brissett has hit the Passing Yards Over in his last 9 games (+9.00 Units / 87% ROI)
  • Jacoby Brissett has hit the Pass Attempts Over in 8 of his last 9 games (+6.80 Units / 64% ROI)
  • Michael Carter has hit the Longest Reception Over in his last 6 games (+6.00 Units / 89% ROI)
  • Jacoby Brissett has hit the Completions Over in his last 5 games (+5.00 Units / 83% ROI)
  • The Atlanta Falcons have covered the 1H Spread in 13 of their last 19 games (+6.20 Units / 28% ROI)
  • The Atlanta Falcons have hit the 1H Moneyline in 11 of their last 19 games (+5.90 Units / 20% ROI)
  • The Atlanta Falcons have hit the Team Total Over in 13 of their last 20 games (+5.00 Units / 21% ROI)
  • The Atlanta Falcons have hit the 3Q Game Total Under in 6 of their last 9 away games (+2.35 Units / 22% ROI)
  • The Atlanta Falcons have hit the Game Total Over in 11 of their last 20 games (+2.25 Units / 10% ROI)
  • The Arizona Cardinals have hit the 4Q Game Total Over in 13 of their last 17 games (+8.50 Units / 44% ROI)
  • The Arizona Cardinals have hit the 2H Game Total Over in their last 7 games at home (+7.00 Units / 87% ROI)
  • The Arizona Cardinals have hit the 1H Team Total Over in 8 of their last 10 games at home (+5.55 Units / 46% ROI)
  • The Arizona Cardinals have hit the 1H Moneyline in 6 of their last 10 games at home (+4.00 Units / 27% ROI)
  • The Arizona Cardinals have covered the 3Q Spread in 11 of their last 17 games (+3.85 Units / 18% ROI)

Falcons Against the Spread (ATS) Record

Against the spread this NFL season, the Falcons are 7-7 (-0.7 Units / -4.53% ROI).

  • Falcons are 5-9 when betting on the Moneyline for -7.1 Units / -35.32% ROI
  • Falcons are 7-6 when betting the Over for +0.4 Units / 2.6% ROI
  • Falcons are 6-7 when betting the Under for -1.7 Units / ROI

Cardinals Against the Spread (ATS) Record

Against the spread this NFL season, the Cardinals are 6-8 (-2.8 Units / -18.18% ROI).

  • Cardinals are 3-11 when betting on the Moneyline for -10.7 Units / -50.59% ROI
  • Cardinals are 9-5 when betting the Over for +3.5 Units / 22.73% ROI
  • Cardinals are 5-9 when betting the Under for -4.9 Units / -31.82% ROI

Atlanta Falcons: Keys to the Game vs. the Arizona Cardinals

The Falcons have a third down conversion rate of 32% this season — 4th-worst in NFL; League Avg: 39%.

The Falcons have converted late downs on just 12 of 186 plays (7%) with 4-6 yards to go this season — 2nd-worst in NFL; League Avg: 10%.

The Falcons have a third down conversion rate of 7% on third and 10+ yards to go this season — worst in NFL; League Avg: 20%.

15 of the Falcons offense’s 31 (48%) TDs have come through the air this season — 2nd-lowest in NFL; League Avg: 61%.

Arizona Cardinals: Keys to the Game vs. the Atlanta Falcons

Cardinals WRs have averaged just 3.8 yards after the catch since the 2024 season — 5th-worst in NFL. The Falcons have allowed just 3.5 yards after catch per reception to WRs since the 2024 season — best in NFL.

The Cardinals have thrown the ball 53.9% of the time in the red zone since the 2024 season — 4th-highest in NFL. The Falcons have allowed a completion rate of 67.3% when defending in the red zone since the 2024 season — 2nd-worst in NFL.

The Cardinals have thrown the ball 53.9% of the time in the red zone since the 2024 season — 4th-highest in NFL. The Falcons have allowed 41 receiving touchdowns when defending in the red zone since the 2024 season — 2nd-most in NFL.

Additional Matchup Notes for Atlanta Falcons vs. Arizona Cardinals

Cardinals WRs have averaged just 3.8 yards after the catch since the 2024 season — 5th-worst in NFL. The Falcons have allowed just 3.5 yards after catch per reception to WRs since the 2024 season — best in NFL.

The Cardinals have thrown the ball 53.9% of the time in the red zone since the 2024 season — 4th-highest in NFL. The Falcons have allowed a completion rate of 67.3% when defending in the red zone since the 2024 season — 2nd-worst in NFL.

The Cardinals have thrown the ball 53.9% of the time in the red zone since the 2024 season — 4th-highest in NFL. The Falcons have allowed 41 receiving touchdowns when defending in the red zone since the 2024 season — 2nd-most in NFL.

The Falcons have a third down conversion rate of 32% this season — 4th-worst in NFL; League Avg: 39%.

The Falcons have converted late downs on just 12 of 186 plays (7%) with 4-6 yards to go this season — 2nd-worst in NFL; League Avg: 10%.

The Falcons have a third down conversion rate of 7% on third and 10+ yards to go this season — worst in NFL; League Avg: 20%.

15 of the Falcons offense’s 31 (48%) TDs have come through the air this season — 2nd-lowest in NFL; League Avg: 61%.

Atlanta Falcons Offense: Important Stats

The Falcons have a third down conversion rate of 32% this season — 4th-worst in NFL; League Avg: 39%.

The Falcons have converted late downs on just 12 of 186 plays (7%) with 4-6 yards to go this season — 2nd-worst in NFL; League Avg: 10%.

The Falcons have a third down conversion rate of 7% on third and 10+ yards to go this season — worst in NFL; League Avg: 20%.

15 of the Falcons offense’s 31 (48%) TDs have come through the air this season — 2nd-lowest in NFL; League Avg: 61%.

Arizona Cardinals Offense: Important Stats

Cardinals WRs have averaged just 3.8 yards after the catch since the 2024 season — 5th-worst in NFL. The Falcons have allowed just 3.5 yards after catch per reception to WRs since the 2024 season — best in NFL.

The Cardinals have thrown the ball 53.9% of the time in the red zone since the 2024 season — 4th-highest in NFL. The Falcons have allowed a completion rate of 67.3% when defending in the red zone since the 2024 season — 2nd-worst in NFL.

The Cardinals have thrown the ball 53.9% of the time in the red zone since the 2024 season — 4th-highest in NFL. The Falcons have allowed 41 receiving touchdowns when defending in the red zone since the 2024 season — 2nd-most in NFL.

Atlanta Falcons Defense: Important Stats

The Falcons have a third down conversion rate of 32% this season — 4th-worst in NFL; League Avg: 39%.

The Falcons have converted late downs on just 12 of 186 plays (7%) with 4-6 yards to go this season — 2nd-worst in NFL; League Avg: 10%.

The Falcons have a third down conversion rate of 7% on third and 10+ yards to go this season — worst in NFL; League Avg: 20%.

15 of the Falcons offense’s 31 (48%) TDs have come through the air this season — 2nd-lowest in NFL; League Avg: 61%.

Arizona Cardinals Defense: Important Stats

Cardinals WRs have averaged just 3.8 yards after the catch since the 2024 season — 5th-worst in NFL. The Falcons have allowed just 3.5 yards after catch per reception to WRs since the 2024 season — best in NFL.

The Cardinals have thrown the ball 53.9% of the time in the red zone since the 2024 season — 4th-highest in NFL. The Falcons have allowed a completion rate of 67.3% when defending in the red zone since the 2024 season — 2nd-worst in NFL.

The Cardinals have thrown the ball 53.9% of the time in the red zone since the 2024 season — 4th-highest in NFL. The Falcons have allowed 41 receiving touchdowns when defending in the red zone since the 2024 season — 2nd-most in NFL.

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.