Colts vs Rams Prediction, Odds & Best Prop Bets – NFL, Week 4

• The Rams are -3.5 point favorites vs the Colts
• Total (Over/Under): 49.5 points
• Watch this game on FOX

The Indianapolis Colts (3-0-0) visit SoFi Stadium to take on the Los Angeles Rams (2-1-0) on Sep. 28. Kickoff is scheduled for 4:05pm EDT in Inglewood, CA.

The Rams are betting favorites in this matchup, with the spread sitting at -3.5 (-110).

The Colts vs. Rams Over/Under is 49.5 total points for the game.

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Colts vs. Rams Odds, Spread, Over/Under

Colts vs. Rams Prediction

The winning team model predicts the Rams will win this game with 69.7% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Colts vs Rams Spread Prediction

Based on recent against-the-spread trends, the model predicts the Colts will cover the spread with 69.7% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Colts players this game, looking at profitable historical betting trends:

Best Colts Player Prop Bets Today

• Jonathan Taylor has hit the Carries Over in 10 of his last 14 games (+5.50 Units / 34% ROI)
• Jonathan Taylor has hit the Rushing Yards Over in 10 of his last 14 games (+5.35 Units / 33% ROI)
• Daniel Jones has hit the TD Passes Under in 8 of his last 10 games (+4.65 Units / 23% ROI)
• Spencer Shrader has hit the Field Goals Over in 5 of his last 6 games (+3.95 Units / 55% ROI)
• Daniel Jones has hit the Completions Over in 7 of his last 10 games (+3.85 Units / 35% ROI)

And here are some top NFL player prop bets for Rams players for this matchup, looking at profitable historical betting trends:

Best Rams Player Prop Best Bets Today

• Puka Nacua has hit the Receiving Yards Over in 11 of his last 15 games (+6.10 Units / 34% ROI)
• Puka Nacua has hit the Receptions Over in 10 of his last 15 games (+4.90 Units / 28% ROI)
• Matthew Stafford has hit the Rushing Yards Under in 8 of his last 11 games (+4.10 Units / 27% ROI)
• Blake Corum has hit the Rushing Yards Under in 5 of his last 6 games at home (+3.85 Units / 57% ROI)
• Colby Parkinson has hit the Receiving Yards Over in 6 of his last 8 games (+3.70 Units / 40% ROI)

Colts Best Bets:

• The Indianapolis Colts have hit the 1H Team Total Over in 15 of their last 20 games (+10.05 Units / 40% ROI)
• The Indianapolis Colts have covered the 1Q Spread in 9 of their last 11 away games (+6.85 Units / 49% ROI)
• The Indianapolis Colts have hit the Game Total Over in 13 of their last 20 games (+6.40 Units / 29% ROI)
• The Indianapolis Colts have hit the 2Q Game Total Over in 11 of their last 17 games (+4.45 Units / 22% ROI)
• The Indianapolis Colts have hit the 1Q Moneyline in 7 of their last 11 away games (+4.05 Units / 28% ROI)

Rams Best Bets:

• The Los Angeles Rams have hit the Moneyline in 14 of their last 22 games (+9.20 Units / 29% ROI)
• The Los Angeles Rams have covered the 2Q Spread in 14 of their last 19 games (+8.35 Units / 38% ROI)
• The Los Angeles Rams have hit the 2Q Moneyline in 13 of their last 19 games (+8.08 Units / 34% ROI)
• The Los Angeles Rams have covered the Spread in 15 of their last 22 games (+7.35 Units / 30% ROI)
• The Los Angeles Rams have hit the 4Q Moneyline in 9 of their last 19 games (+2.16 Units / 9% ROI)

Colts Against the Spread (ATS) Record

Against the spread this NFL season, the Colts are 3-0 (+3 Units / 90.91% ROI).

• Colts are 3-0 when betting on the Moneyline for +3.05 Units / 64.89% ROI
• Colts are 2-1 when betting the Over for +0.9 Units / 27.27% ROI
• Colts are 1-2 when betting the Under for -1.2 Units / ROI

Rams Against the Spread (ATS) Record

Against the spread this NFL season, the Rams are 2-1 (+0.9 Units / 26.87% ROI).

• Rams are 2-1 when betting on the Moneyline for +1 Units / 19.8% ROI
• Rams are 2-1 when betting the Over for +0.9 Units / 27.27% ROI
• Rams are 1-2 when betting the Under for -1.2 Units / -36.36% ROI

Indianapolis Colts: Keys to the Game vs. the Los Angeles Rams

Los Angeles Rams: Keys to the Game vs. the Indianapolis Colts

Additional Matchup Notes for Indianapolis Colts vs. Los Angeles Rams

Indianapolis Colts Offense: Important Stats

Los Angeles Rams Offense: Important Stats

Indianapolis Colts Defense: Important Stats

Los Angeles Rams Defense: Important Stats

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More NFL Betting Predictions:

• Anytime & First Touchdown Scorer Predictions
• Receiving Yards Prop Predictions
• Rushing Yards Prop Predictions
• Passing Yards Prop Predictions
• Receptions Made Prop Predictions
• Rushing Attempts Prop Predictions
• Passing Touchdowns Prop Predictions
• QB Interception Prop Predictions
• Field Goals Made Prop Predictions
• NFL Betting Previews: Every Game

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