- The 49ers are -4.5 point favorites vs the Chargers
- Total (Over/Under): 37.5 points
- Watch this game on
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The Los Angeles Chargers (2-1-0) visit Levi’s Stadium to take on the San Francisco 49ers (1-1-0) on Aug. 23. Kickoff is scheduled for 8:30pm EDT in Santa Clara, CA.
The 49ers are betting favorites in this matchup, with the spread sitting at -4.5 (-115).
The Chargers vs. 49ers Over/Under is 37.5 total points for the game.
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Chargers vs. 49ers Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| Chargers | +4.5 -105 | 37.5 -110 | +200 |
| 49ers | -4.5 -115 | 37.5 -110 | -250 |
Chargers vs. 49ers Prediction
The winning team model predicts the 49ers will win this game with 75.7% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
Chargers vs 49ers Spread Prediction
Based on recent against-the-spread trends, the model predicts the Chargers will cover the spread with 71.3% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
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We’ve highlighted some favorite NFL player prop bets for Chargers players this game, looking at profitable historical betting trends:
Best Chargers Player Prop Bets Today
- Justin Herbert has hit the Interceptions Under in 13 of his last 16 games (+8.55 Units / 40% ROI)
And here are some top NFL player prop bets for 49ers players for this matchup, looking at profitable historical betting trends:
Best 49ers Player Prop Best Bets Today
- Demarcus Robinson has hit the Receptions Under in 15 of his last 17 games (+12.55 Units / 54% ROI)
Chargers Best Bets:
- The Los Angeles Chargers have hit the 1H Moneyline in 15 of their last 21 games (+8.35 Units / 24% ROI)
- The Los Angeles Chargers have covered the Spread in 14 of their last 21 games (+7.40 Units / 32% ROI)
- The Los Angeles Chargers have covered the 1H Spread in 14 of their last 21 games (+7.00 Units / 29% ROI)
- The Los Angeles Chargers have hit the 2H Game Total Over in 8 of their last 10 games (+5.90 Units / 54% ROI)
- The Los Angeles Chargers have hit the 3Q Game Total Over in 8 of their last 10 games (+5.60 Units / 48% ROI)
49ers Best Bets:
- The San Francisco 49ers have hit the 1Q Moneyline in their last 8 games at home (+8.20 Units / 59% ROI)
- The San Francisco 49ers have hit the 2H Game Total Over in 10 of their last 12 games (+7.75 Units / 59% ROI)
- The San Francisco 49ers have hit the 4Q Game Total Over in 10 of their last 12 games (+7.65 Units / 57% ROI)
- The San Francisco 49ers have covered the 1Q Spread in 13 of their last 19 games (+7.35 Units / 33% ROI)
- The San Francisco 49ers have hit the Game Total Over in 12 of their last 19 games (+4.30 Units / 21% ROI)
Los Angeles Chargers: Keys to the Game vs. the San Francisco 49ers
The Chargers were undefeated (9-0) when rushing for more than 100 yards last season — T-best in NFL; League Avg: .618.
The Chargers are 1-9 (.100) when within 3 points at the two minute warning since the 2023 season — worst in NFL; League Avg: .500.
The Chargers were undefeated (8-0) vs bottom 10 offenses last season — T-best in NFL; League Avg: .729.
The Chargers were winless (0-4) vs top 10 run offenses last season — T-worst in NFL; League Avg: .335.
San Francisco 49ers: Keys to the Game vs. the Los Angeles Chargers
The 49ers were winless (0-8) when trailing at the end of the third quarter last season — T-worst in NFL; League Avg: .152.
The 49ers were winless (0-4) when allowing 7 or more explosive plays last season — worst in NFL; League Avg: .402.
The 49ers were winless (0-4) when passing for less than 200 yards last season — T-worst in NFL; League Avg: .422.
The 49ers were winless (0-9) when allowing 120 or more rushing yards last season — T-worst in NFL; League Avg: .354.
Additional Matchup Notes for Los Angeles Chargers vs. San Francisco 49ers
49ers TEs had 70.8 receiving yards per game last season — 5th-best in NFL. The Raiders allowed an average of 64.5 receiving yards per game to TEs last season — 5th-worst in NFL.
The 49ers were successful on 56.8% of plays they ran against a light rush last season — 2nd-best in NFL. The Raiders allowed a success rate of 61.9% with a light rush last season — 5th-worst in NFL.
The 49ers were successful on 60.0% of pass attempts against a light rush last season — 3rd-best in NFL. The Raiders allowed a success rate of 70.6% on pass attempts with a light rush last season — 3rd-worst in NFL.
The Chargers were successful on 56.3% of pass attempts with motion in the last 4 weeks of the regular season — 4th-best in NFL. The Rams pressured opposing QBs on 13.3% of pass attempts against motion in the last 4 weeks of the regular season — 3rd-worst in NFL.
The Chargers had a third down conversion rate of 52.2% in the second half in the last 4 weeks of the regular season — 5th-best in NFL. The Rams defense allowed a third down conversion rate of 52.4% in the second half in the last 4 weeks of the regular season — 5th-worst in NFL.
The Chargers were successful on 55.9% of pass attempts against a heavy rush last season — T-4th-best in NFL. The Rams pressured opposing QBs on 16.7% of pass attempts with a heavy rush last season — worst in NFL.
Los Angeles Chargers Offense: Important Stats
The Chargers threw the ball 19% of the time (12 Pass Attempts/63 plays) on 3rd and short last season — 2nd-lowest in NFL; League Avg: 44%.
The Chargers have started 45 drives inside their own 10 yard line since the 2023 season — most in NFL.
The Chargers ran successful plays on 31% of rush attempts in the 3rd quarter last season — worst in NFL; League Avg: 44%.
The Chargers averaged just 17.6 offensive penalty yards per game (299/17) last season — best in NFL; League Avg: 25.3.
San Francisco 49ers Offense: Important Stats
The 49ers averaged 11.3 yards per play against open coverage last season — best in NFL; League Avg: 9.3.
The 49ers went three and out on 15% of their drives last season — 3rd-best in NFL; League Avg: 21%.
The 49ers have averaged 11.5 yards per play against open coverage since the 2023 season — best in NFL; League Avg: 9.3.
The 49ers have averaged 6.6 yards per play on the road since the 2023 season — best in NFL; League Avg: 5.6.
Los Angeles Chargers Defense: Important Stats
The Chargers defense allowed 7 rushing TDs on 414 carries (59.1 Carries Per TD) last season — best Carries Per TD rate in NFL; League Avg: 27.9.
The Chargers defense allowed 6 TDs that were 20+ yards in the last 4 weeks of the regular season — most in NFL.
The Chargers defense allowed successful plays on 53% of plays open coverage last season — 2nd-best in NFL; League Avg: 60%.
The Chargers defense allowed just 1.1 TDs per game (18/16) in the red zone last season — best in NFL; League Avg: 1.9.
San Francisco 49ers Defense: Important Stats
The 49ers defense allowed a passer rating of just 20.3 when they pressured the QB (69 Pass Attempts) last season — best in NFL; League Avg: 58.2.
The 49ers defense allowed just 5.9 yards per play against play action passes last season — 2nd-best in NFL; League Avg: 7.5.
The 49ers defense allowed 24 rushing TDs last season — T-2nd-most in NFL.
The 49ers defense allowed a third down conversion rate of 33% on 3rd and long last season — 2nd-worst in NFL; League Avg: 25%.
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More NFL Betting Predictions:
- Anytime & First Touchdown Scorer Predictions
- Receiving Yards Prop Predictions
- Rushing Yards Prop Predictions
- Passing Yards Prop Predictions
- Receptions Made Prop Predictions
- Rushing Attempts Prop Predictions
- Passing Touchdowns Prop Predictions
- QB Interception Prop Predictions
- Field Goals Made Prop Predictions
- NFL Betting Previews: Every Game
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