Cardinals vs Seahawks Prediction, Odds & Best Prop Bets – NFL, Week 10

BetMGM Betting Nov 07, 2025, 10:52 AM

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(AP Photo/Scott Eklund)

The Seahawks are -6.5 point favorites vs the Cardinals
Total (Over/Under): 45.5 points
Watch this game on CBS

The Arizona Cardinals (3-5-0) visit Lumen Field to take on the Seattle Seahawks (6-2-0) on Nov. 9. Kickoff is scheduled for 4:05pm EST in Seattle, WA.

The Seahawks are betting favorites in this matchup, with the spread sitting at -6.5 (-115).

The Cardinals vs. Seahawks Over/Under is 45.5 total points for the game.

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Cardinals vs. Seahawks Odds, Spread, Over/Under

	Spread	Total (O/U)	Moneyline
Cardinals	+6.5 -105	45.5 -110	260
Seahawks	-6.5 -115	45.5 -110	-325

Cardinals vs. Seahawks Prediction

The winning team model predicts the Seahawks will win this game with 73.1% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Cardinals vs Seahawks Spread Prediction

Based on recent against-the-spread trends, the model predicts the Cardinals will cover the spread with 50.9% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Cardinals players this game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today

Chad Ryland has hit the Field Goals Over in 12 of his last 16 games (+7.90 Units / 45% ROI)
Kyler Murray has hit the Completions Over in 10 of his last 13 games (+6.50 Units / 43% ROI)
Kyler Murray has hit the Pass Attempts Over in 9 of his last 13 games (+4.50 Units / 30% ROI)
Kyler Murray has hit the Rushing Yards Over in 5 of his last 6 away games (+3.85 Units / 55% ROI)
Trey McBride has hit the Longest Reception Under in 5 of his last 6 games (+3.75 Units / 54% ROI)

And here are some top NFL player prop bets for Seahawks players for this matchup, looking at profitable historical betting trends:

Best Seahawks Player Prop Best Bets Today

Rashid Shaheed has hit the Receptions Over in his last 9 games (+9.70 Units / 98% ROI)
Jaxon Smith-Njigba has hit the Receiving Yards Over in 13 of his last 16 games (+9.55 Units / 52% ROI)
Zach Charbonnet has hit the Carries Over in 10 of his last 14 games (+5.85 Units / 38% ROI)
Jaxon Smith-Njigba has hit the Receptions Over in 6 of his last 7 games at home (+5.30 Units / 68% ROI)
Sam Darnold has hit the Rushing Yards Under in 12 of his last 18 games (+5.05 Units / 25% ROI)

Cardinals Best Bets:

The Arizona Cardinals have hit the 3Q Moneyline in 10 of their last 16 games (+8.15 Units / 37% ROI)
The Arizona Cardinals have covered the 3Q Spread in 12 of their last 16 games (+8.00 Units / 41% ROI)
The Arizona Cardinals have covered the 1Q Spread in 12 of their last 19 games (+4.45 Units / 19% ROI)
The Arizona Cardinals have covered the Spread in 12 of their last 19 games (+4.20 Units / 20% ROI)
The Arizona Cardinals have covered the 2H Spread in 10 of their last 16 games (+3.68 Units / 20% ROI)

Seahawks Best Bets:

The Seattle Seahawks have hit the Moneyline in 13 of their last 19 games (+9.50 Units / 33% ROI)
The Seattle Seahawks have covered the 3Q Spread in 12 of their last 16 games (+8.00 Units / 40% ROI)
The Seattle Seahawks have hit the 3Q Moneyline in 8 of their last 16 games (+6.10 Units / 29% ROI)
The Seattle Seahawks have hit the 1H Moneyline in 12 of their last 19 games (+6.03 Units / 22% ROI)
The Seattle Seahawks have hit the 3Q Game Total Under in 11 of their last 16 games (+5.50 Units / 31% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this NFL season, the Cardinals are 5-3 (+1.7 Units / 19.32% ROI).

Cardinals are 3-5 when betting on the Moneyline for -4.7 Units / -31.02% ROI
Cardinals are 4-4 when betting the Over for -0.4 Units / -4.55% ROI
Cardinals are 4-4 when betting the Under for -0.4 Units / ROI

Seahawks Against the Spread (ATS) Record

Against the spread this NFL season, the Seahawks are 6-2 (+3.8 Units / 42.94% ROI).

Seahawks are 6-2 when betting on the Moneyline for +3.75 Units / 28.85% ROI
Seahawks are 5-3 when betting the Over for +1.7 Units / 19.32% ROI
Seahawks are 3-5 when betting the Under for -2.5 Units / -28.41% ROI

Arizona Cardinals: Keys to the Game vs. the Seattle Seahawks

The Seahawks defense has allowed a passer rating of just 0.0 with a stacked front (4 Pass Attempts) this season — best in NFL; League Avg: 113.3.

The Seahawks defense has allowed a passer rating of just 50.4 when blitzing (50 Pass Attempts) this season — best in NFL; League Avg: 95.0.

The Seahawks defense have allowed -0.86 epa per play with a stacked front this season — best in NFL; League Avg: 0.12.

The Seahawks defense has allowed successful plays on 25% of rush attempts in the 1st quarter this season — best in NFL; League Avg: 44%.

Seattle Seahawks: Keys to the Game vs. the Arizona Cardinals

The Cardinals have targeted TEs 34% of the time (94 Pass Attempts/273 plays) this season — highest in NFL; League Avg: 22%.

The Cardinals have a third down conversion rate of 31% on third and 10+ yards to go this season — 4th-best in NFL; League Avg: 20%.

The Cardinals have converted first downs on 21 of 30 plays (70%) on 3rd and short this season — 5th-best in NFL; League Avg: 60%.

The Cardinals have thrown the ball 33% of the time (10 Pass Attempts/30 plays) on 3rd and short this season — T-3rd-lowest in NFL; League Avg: 44%.

Additional Matchup Notes for Arizona Cardinals vs. Seattle Seahawks