Cardinals vs 49ers Prediction, Odds & Best Prop Bets – NFL, Week 3

• The Favorite Team are Favorite Spread point favorites vs the Underdog Team
• Total (Over/Under): 44.5 points
• Watch this game on FOX

The Arizona Cardinals (2-0-0) visit Levi’s Stadium to take on the San Francisco 49ers (2-0-0) on Sep. 21. Kickoff is scheduled for 4:25pm EDT in Santa Clara, CA.

The Favorite Team are betting favorites in this matchup, with the spread sitting at Favorite Team Spread (Favorite Spread Odds).

The Cardinals vs. 49ers Over/Under is 44.5 total points for the game.

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Cardinals vs. 49ers Odds, Spread, Over/Under

Cardinals vs. 49ers Prediction

The winning team model predicts the 49ers will win this game with 66.3% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Cardinals vs 49ers Spread Prediction

Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread with 66.3% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Cardinals players this game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today

• Chad Ryland has hit the Field Goals Over in 11 of his last 15 games (+7.35 Units / 46% ROI)
• Kyler Murray has hit the TD Passes Under in 13 of his last 17 games (+7.30 Units / 28% ROI)
• Trey McBride has hit the Receiving Yards Over in 11 of his last 16 games (+5.00 Units / 26% ROI)
• James Conner has hit the Receptions Over in 10 of his last 16 games (+4.95 Units / 26% ROI)
• Trey McBride has hit the Receptions Over in 6 of his last 8 away games (+3.90 Units / 40% ROI)

And here are some top NFL player prop bets for 49ers players for this matchup, looking at profitable historical betting trends:

Best 49ers Player Prop Best Bets Today

• Brock Purdy has hit the Carries Over in 11 of his last 14 games (+7.65 Units / 43% ROI)
• Brian Robinson has hit the Receptions Under in 11 of his last 16 games (+5.55 Units / 26% ROI)
• Brock Purdy has hit the Rushing Yards Over in 10 of his last 14 games (+5.40 Units / 34% ROI)
• Jauan Jennings has hit the Receptions Over in 10 of his last 15 games (+5.05 Units / 29% ROI)
• Brock Purdy has hit the TD Passes Under in 6 of his last 8 games at home (+4.10 Units / 48% ROI)

Cardinals Best Bets:

• The Arizona Cardinals have hit the 3Q Moneyline in 10 of their last 17 games (+4.90 Units / 22% ROI)
• The Arizona Cardinals have covered the 3Q Spread in 11 of their last 17 games (+4.55 Units / 23% ROI)
• The Arizona Cardinals have hit the 1H Game Total Over in 11 of their last 19 games (+3.90 Units / 17% ROI)
• The Arizona Cardinals have covered the Spread in 12 of their last 20 games (+3.00 Units / 13% ROI)
• The Arizona Cardinals have covered the 2H Spread in 8 of their last 13 games (+2.93 Units / 20% ROI)

49ers Best Bets:

• The San Francisco 49ers have covered the 1Q Spread in 15 of their last 19 games (+11.85 Units / 55% ROI)
• The San Francisco 49ers have hit the 1Q Moneyline in 13 of their last 18 games (+10.10 Units / 38% ROI)
• The San Francisco 49ers have hit the 2H Game Total Over in 12 of their last 15 games (+8.63 Units / 52% ROI)
• The San Francisco 49ers have hit the 4Q Game Total Over in 12 of their last 17 games (+7.25 Units / 38% ROI)
• The San Francisco 49ers have hit the Game Total Over in 13 of their last 20 games (+5.30 Units / 24% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this NFL season, the Cardinals are 1-1 (-0.1 Units / -4.55% ROI).

• Cardinals are 2-0 when betting on the Moneyline for +2 Units / 33.61% ROI
• Cardinals are 1-1 when betting the Over for -0.1 Units / -4.55% ROI
• Cardinals are 1-1 when betting the Under for -0.1 Units / ROI

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 2-0 (+2 Units / 90.91% ROI).

• 49ers are 2-0 when betting on the Moneyline for +2 Units / 68.97% ROI
• 49ers are 1-1 when betting the Over for -0.1 Units / -4.55% ROI
• 49ers are 1-1 when betting the Under for -0.1 Units / -4.55% ROI

Arizona Cardinals: Keys to the Game vs. the San Francisco 49ers

San Francisco 49ers: Keys to the Game vs. the Arizona Cardinals

Additional Matchup Notes for Arizona Cardinals vs. San Francisco 49ers

Arizona Cardinals Offense: Important Stats

San Francisco 49ers Offense: Important Stats

Arizona Cardinals Defense: Important Stats

San Francisco 49ers Defense: Important Stats

Looking to place a bet on this game with a First Bet Offer up to $1,500? Bet now on 49ers vs Cardinals and all NFL games with BetMGM

More NFL Betting Predictions:

• Anytime & First Touchdown Scorer Predictions
• Receiving Yards Prop Predictions
• Rushing Yards Prop Predictions
• Passing Yards Prop Predictions
• Receptions Made Prop Predictions
• Rushing Attempts Prop Predictions
• Passing Touchdowns Prop Predictions
• QB Interception Prop Predictions
• Field Goals Made Prop Predictions
• NFL Betting Previews: Every Game

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