Buccaneers vs Panthers Prediction, Odds & Best Prop Bets – NFL, Week 16

BetMGM Betting Dec 19, 2025, 6:00 PM

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Fans stand for the national anthem before an NFL football game between the Carolina Panthers and the New Orleans Saints Monday, Sept. 18, 2023, in Charlotte, N.C. (AP Photo/Rusty Jones)

(AP Photo/Rusty Jones)

The Buccaneers are -3 point favorites vs the Panthers
Total (Over/Under): 45.5 points
Watch this game on FOX

The Tampa Bay Buccaneers (7-7-0) visit Bank of America Stadium to take on the Carolina Panthers (7-7-0) on Dec. 21. Kickoff is scheduled for 1:00pm EST in Charlotte, NC.

The Buccaneers are betting favorites in this matchup, with the spread sitting at -3 (-105).

The Buccaneers vs. Panthers Over/Under is 45.5 total points for the game.

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Buccaneers vs. Panthers Odds, Spread, Over/Under

Buccaneers vs. Panthers Prediction

The winning team model predicts the Buccaneers will win this game with 59.4% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Buccaneers vs Panthers Spread Prediction

Based on recent against-the-spread trends, the model predicts the Buccaneers will cover the spread with 59.3% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Buccaneers players this game, looking at profitable historical betting trends:

Best Buccaneers Player Prop Bets Today

Rachaad White has hit the Carries Under in 13 of his last 17 games (+9.10 Units / 47% ROI)
Sterling Shepard has hit the Longest Reception Under in 8 of his last 10 games (+5.75 Units / 50% ROI)
Sterling Shepard has hit the Receptions Over in 6 of his last 8 away games (+5.35 Units / 63% ROI)
Emeka Egbuka has hit the Receptions Under in 10 of his last 14 games (+5.10 Units / 29% ROI)
Tez Johnson has hit the Longest Reception Under in his last 5 games (+5.00 Units / 90% ROI)

And here are some top NFL player prop bets for Panthers players for this matchup, looking at profitable historical betting trends:

Best Panthers Player Prop Best Bets Today

Bryce Young has hit the Completions Under in 13 of his last 15 games (+10.85 Units / 63% ROI)
Bryce Young has hit the Pass Attempts Under in 12 of his last 15 games (+8.50 Units / 48% ROI)
Bryce Young has hit the Passing Yards Under in 12 of his last 16 games (+7.40 Units / 40% ROI)
Ja’Tavion Sanders has hit the Longest Reception Under in 8 of his last 9 games (+6.95 Units / 68% ROI)
Xavier Legette has hit the Receiving Yards Under in 10 of his last 14 games (+5.50 Units / 34% ROI)

Buccaneers Best Bets:

The Tampa Bay Buccaneers have covered the 3Q Spread in 12 of their last 18 games (+6.10 Units / 30% ROI)
The Tampa Bay Buccaneers have hit the 3Q Game Total Over in 12 of their last 18 games (+5.80 Units / 27% ROI)
The Tampa Bay Buccaneers have hit the 2Q Moneyline in 6 of their last 8 away games (+4.90 Units / 51% ROI)
The Tampa Bay Buccaneers have hit the 3Q Moneyline in 10 of their last 18 games (+4.85 Units / 18% ROI)
The Tampa Bay Buccaneers have hit the Game Total Over in 13 of their last 21 games (+4.20 Units / 18% ROI)

Panthers Best Bets:

The Carolina Panthers have hit the Moneyline in 9 of their last 20 games (+7.97 Units / 34% ROI)
The Carolina Panthers have hit the 2H Moneyline in 9 of their last 17 games (+7.23 Units / 39% ROI)
The Carolina Panthers have hit the 3Q Moneyline in 8 of their last 17 games (+6.55 Units / 36% ROI)
The Carolina Panthers have covered the 3Q Spread in 12 of their last 17 games (+6.55 Units / 31% ROI)
The Carolina Panthers have covered the 1Q Spread in 12 of their last 18 games (+5.95 Units / 27% ROI)

Buccaneers Against the Spread (ATS) Record

Against the spread this NFL season, the Buccaneers are 5-9 (-5 Units / -32.47% ROI).

Buccaneers are 7-7 when betting on the Moneyline for -4.15 Units / -17.11% ROI
Buccaneers are 8-6 when betting the Over for +1.4 Units / 9.09% ROI
Buccaneers are 6-8 when betting the Under for -2.8 Units / ROI

Panthers Against the Spread (ATS) Record

Against the spread this NFL season, the Panthers are 8-6 (+1.35 Units / 8.65% ROI).

Panthers are 7-7 when betting on the Moneyline for +8.3 Units / 52.2% ROI
Panthers are 7-7 when betting the Over for -0.7 Units / -4.55% ROI
Panthers are 7-7 when betting the Under for -0.7 Units / -4.55% ROI

Tampa Bay Buccaneers: Keys to the Game vs. the Carolina Panthers

The Panthers defense has allowed first downs on 48% of pass attempts on 3rd and long this season — worst in NFL; League Avg: 29%.

The Panthers defense has allowed a third down conversion rate of 38% on 3rd and long this season — worst in NFL; League Avg: 25%.

The Panthers defense has allowed a third down conversion rate of 32% on third and 10+ yards to go this season — 2nd-worst in NFL; League Avg: 20%.

The Panthers defense has allowed first downs on 50% of pass attempts on 3rd down this season — worst in NFL; League Avg: 38%.

Carolina Panthers: Keys to the Game vs. the Tampa Bay Buccaneers

The Buccaneers have run successful plays on 42% of plays on first read passes this season — 2nd-worst in NFL; League Avg: 52%.

The Buccaneers have run successful plays on 42% of pass attempts on first read passes this season — 2nd-worst in NFL; League Avg: 52%.

The Buccaneers have run 6% of their plays in the red zone in the 1st quarter this season — worst in NFL; League Avg: 13%.

The Buccaneers have averaged -0.60 epa per play on contested throws this season — 2nd-worst in NFL; League Avg: -0.09.

Additional Matchup Notes for Tampa Bay Buccaneers vs. Carolina Panthers