Broncos vs Colts Prediction, Odds & Best Prop Bets – NFL, Week 2

BetMGM Betting Sep 14, 2025, 8:45 AM

min read

A general overall interior view of Lucas Oil Stadium as Chicago Bears take on the Indianapolis Colts during an NFL football game, Sunday, Sept. 22, 2024, in Indianapolis. The Colts defeated the Bears 21-16. (AP Photo/Zach Bolinger)

(AP Photo/Zach Bolinger)

The Broncos are -2 point favorites vs the Colts
Total (Over/Under): 42.5 points
Watch this game on CBS

The Denver Broncos (1-0-0) visit Lucas Oil Stadium to take on the Indianapolis Colts (1-0-0) on Sep. 14. Kickoff is scheduled for 4:05pm EDT in Indianapolis, IN.

The Broncos are betting favorites in this matchup, with the spread sitting at -2 (-110).

The Broncos vs. Colts Over/Under is 42.5 total points for the game.

Bet now on Colts vs Broncos & all NFL games with BetMGM

Broncos vs. Colts Odds, Spread, Over/Under

	Spread	Total (O/U)	Moneyline
Broncos	-2 -110	42.5 -110	-130
Colts	++2 -110	42.5 -110	110

Broncos vs. Colts Prediction

The winning team model predicts the Broncos will win this game with 56.1% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Broncos vs Colts Spread Prediction

Based on recent against-the-spread trends, the model predicts the Colts will cover the spread with 66.4% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

Bet now on Colts vs Broncos and all NFL games with BetMGM

Get a New Player Offer

We’ve highlighted some favorite NFL player prop bets for Broncos players this game, looking at profitable historical betting trends:

Best Broncos Player Prop Bets Today

Evan Engram has hit the Receiving Yards Under in his last 7 games (+7.00 Units / 88% ROI)
Bo Nix has hit the Interceptions Under in 11 of his last 16 games (+6.80 Units / 38% ROI)
Bo Nix has hit the TD Passes Over in 11 of his last 15 games (+6.60 Units / 31% ROI)
Courtland Sutton has hit the Receiving Yards Over in 11 of his last 15 games (+6.40 Units / 36% ROI)
Bo Nix has hit the Passing Yards Over in 12 of his last 17 games (+6.05 Units / 30% ROI)

And here are some top NFL player prop bets for Colts players for this matchup, looking at profitable historical betting trends:

Best Colts Player Prop Best Bets Today

Jonathan Taylor has hit the Receiving Yards Under in his last 9 games (+9.00 Units / 88% ROI)
Jonathan Taylor has hit the Carries Over in 10 of his last 12 games (+7.80 Units / 56% ROI)
Jonathan Taylor has hit the Receptions Under in 9 of his last 11 games (+7.45 Units / 56% ROI)
Anthony Richardson has hit the Passing Yards Under in 8 of his last 9 games (+6.85 Units / 67% ROI)
Anthony Richardson has hit the TD Passes Under in his last 5 games at home (+6.60 Units / 66% ROI)

Broncos Best Bets:

The Denver Broncos have hit the Moneyline in 14 of their last 21 games (+10.35 Units / 24% ROI)
The Denver Broncos have hit the 1H Game Total Over in 14 of their last 19 games (+8.10 Units / 36% ROI)
The Denver Broncos have covered the Spread in 14 of their last 21 games (+6.35 Units / 28% ROI)
The Denver Broncos have covered the 1Q Spread in 8 of their last 10 away games (+6.10 Units / 52% ROI)
The Denver Broncos have hit the 3Q Moneyline in 10 of their last 15 games (+5.75 Units / 25% ROI)

Colts Best Bets:

The Indianapolis Colts have hit the 2Q Game Total Over in 7 of their last 8 games (+5.95 Units / 62% ROI)
The Indianapolis Colts have hit the 3Q Game Total Under in 10 of their last 14 games (+5.30 Units / 33% ROI)
The Indianapolis Colts have hit the 4Q Game Total Over in 6 of their last 8 games (+5.00 Units / 56% ROI)
The Indianapolis Colts have hit the 1H Team Total Over in 11 of their last 18 games (+3.35 Units / 15% ROI)
The Indianapolis Colts have covered the 2Q Spread in 5 of their last 7 games at home (+2.80 Units / 34% ROI)

Broncos Against the Spread (ATS) Record

Against the spread this NFL season, the Broncos are 0-1 (-1.1 Units / -100% ROI).

Broncos are 1-0 when betting on the Moneyline for +1 Units / 21.74% ROI
Broncos are 0-1 when betting the Over for -1.1 Units / -100% ROI
Broncos are 1-0 when betting the Under for +1 Units / ROI

Colts Against the Spread (ATS) Record

Against the spread this NFL season, the Colts are 1-0 (+1 Units / 90.91% ROI).

Colts are 1-0 when betting on the Moneyline for +1 Units / 83.33% ROI
Colts are 0-1 when betting the Over for -1.1 Units / -100% ROI
Colts are 1-0 when betting the Under for +1 Units / 90.91% ROI

Denver Broncos: Keys to the Game vs. the Indianapolis Colts

The Broncos were 6-2 (.750) when possessing the ball longer than their opponent last season — T-9th-best in NFL. The Colts allowed an average time of possession of 32 min and 20 s last season — 3rd-highest in NFL.

The Broncos were 9-3 (.750) when forcing 1 or more turnovers last season — 7th-best in NFL. The Colts turned the ball over 28 times last season — T-3rd-most in NFL.

The Broncos were 3-4 (.429) when rushing less than 25 times last season — T-8th-best in NFL; League Avg: .278.

The Broncos were 7-2 (.778) when making 7 or more explosive plays last season — T-6th-best in NFL; League Avg: .598.

Indianapolis Colts: Keys to the Game vs. the Denver Broncos

The Colts were 4-4 (.500) when forcing 2 or more turnovers last season — T-5th-worst in NFL; League Avg: .730.

The Colts were 2-4 (.333) after a win last season — T-9th-worst in NFL; League Avg: .588.

The Colts were winless (0-4) vs top 10 offenses last season — T-worst in NFL; League Avg: .318.

The Colts were 2-6 (.250) when allowing more than 3 explosive runs last season — T-9th-worst in NFL; League Avg: .405.

Additional Matchup Notes for Denver Broncos vs. Indianapolis Colts

The Colts were successful on just 21.5% of pass attempts when their QB was under pressure last season — worst in NFL. The Broncos had pressured opposing QBs on 30.4% of passing plays last season — 2nd-best in NFL.

The Colts were successful on just 37.5% of rush attempts against a stacked front last season — 4th-worst in NFL. The Broncos allowed a success rate of just 36.2% on rush attempts with a stacked front last season — 5th-best in NFL.

The Colts had an average drive start position from the 26.2 yard line last season — 4th-worst in NFL. The Broncos allowed an average drive start position from the 26.3 yard line last season — 5th-best in NFL.

The Broncos went three and out on 7.1% of their drives last week — 5th-best in NFL. The Colts forced three and outs on 0% of opponent drives last week — T-worst in NFL.

The Broncos were 9-3 (.750) when forcing 1 or more turnovers last season — 7th-best in NFL. The Colts turned the ball over 28 times last season — T-3rd-most in NFL.

Denver Broncos Offense: Important Stats

The Broncos averaged 0.17 epa per play on contested throws last season — 3rd-best in NFL; League Avg: -0.06.

The Broncos ran 26% of their plays in their opponent’s territory in the 1st half in Week 1 — 2nd-worst in NFL; League Avg: 50%.

The Broncos converted late downs on 17 of 62 plays (27%) in short yardage situations in the last 4 weeks of the regular season — best in NFL; League Avg: 17%.

The Broncos averaged 0.23 epa per play on play action passes last season — 5th-best in NFL; League Avg: 0.09.

Indianapolis Colts Offense: Important Stats

The Colts scored on 100% of their drives (7/7) in Week 1 — best in NFL; League Avg: 40%.

The Colts ran successful plays on 21% of pass attempts on passes when their QB was pressured last season — worst in NFL; League Avg: 32%.

The Colts scored 6 TDs from their own territory last season — 2nd-most in NFL.

The Colts ran successful plays on 42% of pass attempts on play action passes last season — 2nd-worst in NFL; League Avg: 52%.

Denver Broncos Defense: Important Stats

The Broncos defense allowed successful plays on 37% of plays on motion plays last season — best in NFL; League Avg: 44%.

The Broncos defense allowed successful plays on 24% of rush attempts in the 4th quarter last season — best in NFL; League Avg: 41%.

The Broncos defense allowed successful plays on 38% of plays last season — best in NFL; League Avg: 43%.

The Broncos defense allowed -0.10 epa per play last season — T-best in NFL; League Avg: 0.01.

Indianapolis Colts Defense: Important Stats

The Colts defense allowed -1.03 epa per play with a stacked front in the last 4 weeks of the regular season — best in NFL; League Avg: -0.01.

The Colts defense allowed successful plays on 49% of pass attempts on contested throws last season — T-worst in NFL; League Avg: 35%.

The Colts defense missed 156 tackles last season — most in NFL.

The Colts defense allowed 11.1 yards per play on first drive of the game in the last 4 weeks of the regular season — worst in NFL; League Avg: 5.8.

Looking to place a bet on this game with a First Bet Offer up to $1,500? Bet now on Colts vs Broncos and all NFL games with BetMGM

More NFL Betting Predictions:

More NFL Odds at BetMGM

Take your football entertainment to the next level with NFL betting at the online sportsbook.

From futures like Chiefs Super Bowl odds, Lions odds to win the division, or Ravens playoff odds, to weekly odds like spreads, moneylines, and over/under totals, there’s something for everyone.

And with the best sportsbook promotions, you could land a welcome offer, sports betting Odds Boost, or a Parlay Boost! You can also check out NFL picks and predictions and updated Super Bowl predictions throughout the year.

Log in to your BetMGM account today — or sign up for a new account via the online sportsbook or BetMGM iOS app or BetMGM Android app — to start betting!

The content provided in this blog is intended for entertainment purposes only. All views and opinions expressed are the authors and reflect their individual perspectives on sports, betting, and related topics. This content should not be considered professional betting advice or the official views of BetMGM LLC. Please gamble responsibly. If you or someone you know is experiencing issues related to gambling, seek help from a licensed health professional. This blog is not liable for any losses, damages, or consequences resulting from betting activities.

About the Author

BetMGM Betting