- The 49ers are -2.5 point favorites vs the Seahawks
- Total (Over/Under): 43.5 points
- Watch this game on FOX
The San Francisco 49ers (0-0-0) visit Lumen Field to take on the Seattle Seahawks (0-0-0) on Sep. 7. Kickoff is scheduled for 4:05pm EDT in Seattle, WA.
The 49ers are betting favorites in this matchup, with the spread sitting at -2.5 (-110).
The 49ers vs. Seahawks Over/Under is 43.5 total points for the game.
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49ers vs. Seahawks Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| 49ers | -2.5 -110 | 43.5 -115 | -135 |
| Seahawks | +2.5 -110 | 43.5 -105 | +115 |
49ers vs. Seahawks Prediction
The winning team model predicts the 49ers will win this game with 60.1% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
49ers vs Seahawks Spread Prediction
Based on recent against-the-spread trends, the model predicts the Seahawks will cover the spread with 66.4% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
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We’ve highlighted some favorite NFL player prop bets for 49ers players this game, looking at profitable historical betting trends:
Best 49ers Player Prop Bets Today
- Demarcus Robinson has hit the Receptions Under in 15 of his last 17 games (+12.55 Units / 54% ROI)
And here are some top NFL player prop bets for Seahawks players for this matchup, looking at profitable historical betting trends:
Best Seahawks Player Prop Best Bets Today
- Sam Darnold has hit the Pass Attempts Over in 9 of his last 11 games (+6.90 Units / 55% ROI)
49ers Best Bets:
- The San Francisco 49ers have hit the 2H Game Total Over in 10 of their last 12 games (+7.75 Units / 59% ROI)
- The San Francisco 49ers have hit the 4Q Game Total Over in 10 of their last 12 games (+7.65 Units / 57% ROI)
- The San Francisco 49ers have covered the 1Q Spread in 13 of their last 19 games (+7.35 Units / 34% ROI)
- The San Francisco 49ers have hit the Game Total Over in 13 of their last 20 games (+5.30 Units / 24% ROI)
- The San Francisco 49ers have hit the 1Q Moneyline in 11 of their last 18 games (+5.00 Units / 19% ROI)
Seahawks Best Bets:
- The Seattle Seahawks have covered the 4Q Spread in 9 of their last 11 games (+6.75 Units / 47% ROI)
- The Seattle Seahawks have hit the 2Q Moneyline in 7 of their last 11 games (+5.75 Units / 40% ROI)
- The Seattle Seahawks have hit the 4Q Game Total Over in 6 of their last 7 games at home (+4.90 Units / 60% ROI)
- The Seattle Seahawks have hit the 2H Moneyline in 6 of their last 12 games (+3.95 Units / 29% ROI)
- The Seattle Seahawks have covered the 3Q Spread in 6 of their last 8 games (+3.50 Units / 32% ROI)
49ers Against the Spread (ATS) Record
Against the spread this NFL preseason, the 49ers were 2-1 (+0.85 Units / 26.15% ROI).
- 49ers are 2-1 when betting on the Moneyline for +2.1 Units / 70% ROI
- 49ers are 3-0 when betting the Over for +3 Units / 91.46% ROI
- 49ers are 0-3 when betting the Under for -3.32 Units / ROI
Seahawks Against the Spread (ATS) Record
Against the spread this NFL preseason, the Seahawks were 2-1 (+1 Units / 30.77% ROI).
- Seahawks are 1-1 when betting on the Moneyline for +0 Units / 0% ROI
- Seahawks are 2-1 when betting the Over for +0.9 Units / 27.95% ROI
- Seahawks are 1-2 when betting the Under for -1.28 Units / -37.87% ROI
San Francisco 49ers: Keys to the Game vs. the Seattle Seahawks
The 49ers were winless (0-7) when scoring less than 22 points last season — T-worst in NFL; League Avg: .229.
The 49ers are winless (0-6) when passing for less than 200 yards since the 2023 season — worst in NFL; League Avg: .409.
The 49ers are undefeated (6-0) vs bottom 10 pass offenses since the 2023 season — best in NFL; League Avg: .624.
The 49ers were 1-9 (.100) when allowing 100 or more rushing yards last season — T-worst in NFL; League Avg: .382.
Seattle Seahawks: Keys to the Game vs. the San Francisco 49ers
The Seahawks were 7-1 (.875) on the road last season — 2nd-best in NFL; League Avg: .476.
The Seahawks were 2-3 (.400) vs top 10 run defenses last season — T-8th-best in NFL; League Avg: .300.
The Seahawks were 7-4 (.636) when allowing less than 5 yards per rush last season — 10th-best in NFL; League Avg: .526.
The Seahawks were 7-3 (.700) when making 5 or more explosive passes in a game last season — 10th-best in NFL; League Avg: .567.
Additional Matchup Notes for San Francisco 49ers vs. Seattle Seahawks
The Seahawks were successful on 50.3% of pass attempts against a light front last season — 4th-best in NFL. The 49ers allowed a success rate of 48.7% on pass attempts with a light front last season — 4th-worst in NFL.
Seahawks RBs averaged a TD every 21.5 carries last season — 4th-best in NFL. The 49ers allowed a touchdown every just 19.2 carries last season — 2nd-worst carries per TD rate in NFL.
49ers RBs gained 9.7 Yards Per Reception last season — 3rd-best in NFL. The Seahawks allowed 8.4 Yards Per Reception to RBs last season — T-3rd-worst in NFL.
The 49ers threw for 20+ yards on 16 of 154 attempts in the last 4 weeks of the regular season — 4th-best in NFL. The Seahawks allowed 20+ yards on 9.9% of attempts in the last 4 weeks of the regular season — 5th-worst in NFL.
49ers TEs averaged 6.3 yards after the catch last season — 2nd-best in NFL. The Seahawks allowed 5.4 yards after catch per reception to TEs last season — 5th-worst in NFL.
San Francisco 49ers Offense: Important Stats
The 49ers averaged 11.3 yards per play against open coverage last season — best in NFL; League Avg: 9.3.
The 49ers have averaged 11.5 yards per play against open coverage since the 2023 season — best in NFL; League Avg: 9.3.
The 49ers have completed passes for 20+ yards on 141 of their 1,024 total passing attempts (14%) since the 2023 season — best in NFL; League Avg: 9%.
The 49ers have averaged 6.6 yards per play on the road since the 2023 season — best in NFL; League Avg: 5.6.
Seattle Seahawks Offense: Important Stats
The Seahawks started 7 drives inside opposing territory last season — 2nd-fewest in NFL.
The Seahawks ran successful plays on 31% of plays against a stacked front last season — worst in NFL; League Avg: 47%.
The Seahawks ran 8% of their plays in the red zone in the 1st quarter last season — 2nd-worst in NFL; League Avg: 12%.
The Seahawks converted fourth downs on just 6 of 14 plays (43%) in short yardage situations last season — 2nd-worst in NFL; League Avg: 66%.
San Francisco 49ers Defense: Important Stats
The 49ers defense allowed a passer rating of just 20.3 when they pressured the QB (69 Pass Attempts) last season — best in NFL; League Avg: 58.2.
The 49ers defense have allowed just 3.9 yards per play on contested throws since the 2023 season — best in NFL; League Avg: 5.3.
The 49ers defense allowed a Completion Pct of just 28% (19 completions/69 attempts) when they pressured the QB last season — 2nd-best in NFL; League Avg: 42%.
The 49ers defense allowed just 5.9 yards per play against play action passes last season — 2nd-best in NFL; League Avg: 7.5.
Seattle Seahawks Defense: Important Stats
The Seahawks defense forced three and outs on 27% of opponent drives in the 4th quarter last season — best in NFL; League Avg: 15%.
The Seahawks defense allowed scores on 22% of opponent drives (13/60) in the 4th quarter last season — best in NFL; League Avg: 35%.
The Seahawks defense allowed a third down conversion rate of 20% on 3rd and long last season — T-4th-best in NFL; League Avg: 25%.
The Seahawks defense allowed a passer rating of 120.5 against play action passes (143 Pass Attempts) last season — 3rd-worst in NFL; League Avg: 103.1.
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More NFL Betting Predictions:
- Anytime & First Touchdown Scorer Predictions
- Receiving Yards Prop Predictions
- Rushing Yards Prop Predictions
- Passing Yards Prop Predictions
- Receptions Made Prop Predictions
- Rushing Attempts Prop Predictions
- Passing Touchdowns Prop Predictions
- QB Interception Prop Predictions
- Field Goals Made Prop Predictions
- NFL Betting Previews: Every Game
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