49ers vs Rams Prediction, Odds & Best Prop Bets – NFL, Week 5

• The Rams are -7 point favorites vs the 49ers
• Total (Over/Under): 46.5 points
• Watch this game on Amazon

The San Francisco 49ers (3-1-0) visit SoFi Stadium to take on the Los Angeles Rams (3-1-0) on Oct. 2. Kickoff is scheduled for 8:15pm EDT in Inglewood, CA.

The Rams are betting favorites in this matchup, with the spread sitting at -7 (-105).

The 49ers vs. Rams Over/Under is 46.5 total points for the game.

Bet now on Rams vs 49ers & all NFL games with BetMGM

49ers vs. Rams Odds, Spread, Over/Under

49ers vs. Rams Prediction

The winning team model predicts the Rams will win this game with 75.9% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

49ers vs Rams Spread Prediction

Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread with 68.5% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

Bet now on Rams vs 49ers and all NFL games with BetMGM

We’ve highlighted some favorite NFL player prop bets for 49ers players this game, looking at profitable historical betting trends:

Best 49ers Player Prop Bets Today

• Demarcus Robinson has hit the Receptions Under in 12 of his last 14 games (+9.30 Units / 47% ROI)
• Brian Robinson has hit the Receptions Under in 11 of his last 15 games (+7.15 Units / 37% ROI)
• Christian McCaffrey has hit the Rushing Yards Under in 7 of his last 8 games (+5.85 Units / 64% ROI)
• Eddy Pineiro has hit the Field Goals Under in 6 of his last 7 away games (+5.00 Units / 54% ROI)
• Brock Purdy has hit the Rushing Yards Over in 9 of his last 13 games (+4.40 Units / 29% ROI)

And here are some top NFL player prop bets for Rams players for this matchup, looking at profitable historical betting trends:

Best Rams Player Prop Best Bets Today

• Puka Nacua has hit the Receiving Yards Over in 12 of his last 16 games (+7.10 Units / 38% ROI)
• Puka Nacua has hit the Receptions Over in 11 of his last 16 games (+5.90 Units / 31% ROI)
• Blake Corum has hit the Rushing Yards Under in 6 of his last 7 games at home (+4.85 Units / 62% ROI)
• Tyler Higbee has hit the Receptions Over in 5 of his last 7 games (+3.20 Units / 37% ROI)
• Colby Parkinson has hit the Receiving Yards Over in 4 of his last 5 games (+2.90 Units / 50% ROI)

49ers Best Bets:

• The San Francisco 49ers have covered the 1Q Spread in 15 of their last 20 games (+10.95 Units / 48% ROI)
• The San Francisco 49ers have hit the 1Q Moneyline in 12 of their last 19 games (+9.10 Units / 36% ROI)
• The San Francisco 49ers have hit the 4Q Game Total Over in 12 of their last 17 games (+7.10 Units / 37% ROI)
• The San Francisco 49ers have hit the 2H Game Total Over in 11 of their last 15 games (+6.51 Units / 39% ROI)
• The San Francisco 49ers have hit the 2Q Game Total Over in 6 of their last 8 away games (+3.75 Units / 41% ROI)

Rams Best Bets:

• The Los Angeles Rams have hit the Moneyline in 15 of their last 22 games (+11.20 Units / 35% ROI)
• The Los Angeles Rams have covered the 2Q Spread in 15 of their last 19 games (+10.60 Units / 48% ROI)
• The Los Angeles Rams have hit the 2Q Moneyline in 14 of their last 19 games (+10.08 Units / 41% ROI)
• The Los Angeles Rams have covered the Spread in 16 of their last 22 games (+9.40 Units / 39% ROI)
• The Los Angeles Rams have covered the 1H Spread in 13 of their last 22 games (+4.05 Units / 17% ROI)

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 2-2 (-0.2 Units / -4.55% ROI).

• 49ers are 3-1 when betting on the Moneyline for +1.35 Units / 23.28% ROI
• 49ers are 2-2 when betting the Over for -0.2 Units / -4.55% ROI
• 49ers are 2-2 when betting the Under for -0.2 Units / ROI

Rams Against the Spread (ATS) Record

Against the spread this NFL season, the Rams are 3-1 (+1.9 Units / 42.7% ROI).

• Rams are 3-1 when betting on the Moneyline for +2 Units / 28.99% ROI
• Rams are 2-2 when betting the Over for -0.2 Units / -4.55% ROI
• Rams are 2-2 when betting the Under for -0.2 Units / -4.55% ROI

San Francisco 49ers: Keys to the Game vs. the Los Angeles Rams

The 49ers defense has allowed a passer rating of 98.9 with tight coverage (23 Pass Attempts) this season — worst in NFL; League Avg: 20.2.

The 49ers defense has allowed a passer rating of just 24.0 when they have pressured the QB (80 Pass Attempts) since the 2024 season — best in NFL; League Avg: 56.2.

The 49ers defense has allowed just 8.2 yards per completion (690 yards/84 completions) this season — best in NFL; League Avg: 10.5.

The 49ers defense have allowed 5.9 yards per play with tight coverage this season — 3rd-worst in NFL; League Avg: 3.0.

Los Angeles Rams: Keys to the Game vs. the San Francisco 49ers

49ers RBs have averaged just 1.1 yards after contact per carry this season — worst in NFL. The Rams have allowed just 1.4 yards after contact per carry to RBs this season — 4th-best in NFL.

The 49ers went three and out on 14.6% of their drives last season — 3rd-best in NFL. The Rams forced three and outs on 16.8% of opponent drives last season — 4th-worst in NFL.

The 49ers have thrown for 20+ yards on 82 of 686 attempts since the 2024 season — best in NFL. The Rams allowed 20+ yards on 10.3% of attempts since the 2024 season — T-4th-worst in NFL.

Additional Matchup Notes for San Francisco 49ers vs. Los Angeles Rams

49ers RBs have averaged just 1.1 yards after contact per carry this season — worst in NFL. The Rams have allowed just 1.4 yards after contact per carry to RBs this season — 4th-best in NFL.

The 49ers went three and out on 14.6% of their drives last season — 3rd-best in NFL. The Rams forced three and outs on 16.8% of opponent drives last season — 4th-worst in NFL.

The 49ers have thrown for 20+ yards on 82 of 686 attempts since the 2024 season — best in NFL. The Rams allowed 20+ yards on 10.3% of attempts since the 2024 season — T-4th-worst in NFL.

The 49ers defense has allowed a passer rating of 98.9 with tight coverage (23 Pass Attempts) this season — worst in NFL; League Avg: 20.2.

The 49ers defense has allowed a passer rating of just 24.0 when they have pressured the QB (80 Pass Attempts) since the 2024 season — best in NFL; League Avg: 56.2.

The 49ers defense has allowed just 8.2 yards per completion (690 yards/84 completions) this season — best in NFL; League Avg: 10.5.

The 49ers defense have allowed 5.9 yards per play with tight coverage this season — 3rd-worst in NFL; League Avg: 3.0.

San Francisco 49ers Offense: Important Stats

The 49ers defense has allowed a passer rating of 98.9 with tight coverage (23 Pass Attempts) this season — worst in NFL; League Avg: 20.2.

The 49ers defense has allowed a passer rating of just 24.0 when they have pressured the QB (80 Pass Attempts) since the 2024 season — best in NFL; League Avg: 56.2.

The 49ers defense has allowed just 8.2 yards per completion (690 yards/84 completions) this season — best in NFL; League Avg: 10.5.

The 49ers defense have allowed 5.9 yards per play with tight coverage this season — 3rd-worst in NFL; League Avg: 3.0.

Los Angeles Rams Offense: Important Stats

49ers RBs have averaged just 1.1 yards after contact per carry this season — worst in NFL. The Rams have allowed just 1.4 yards after contact per carry to RBs this season — 4th-best in NFL.

The 49ers went three and out on 14.6% of their drives last season — 3rd-best in NFL. The Rams forced three and outs on 16.8% of opponent drives last season — 4th-worst in NFL.

The 49ers have thrown for 20+ yards on 82 of 686 attempts since the 2024 season — best in NFL. The Rams allowed 20+ yards on 10.3% of attempts since the 2024 season — T-4th-worst in NFL.

San Francisco 49ers Defense: Important Stats

The 49ers defense has allowed a passer rating of 98.9 with tight coverage (23 Pass Attempts) this season — worst in NFL; League Avg: 20.2.

The 49ers defense has allowed a passer rating of just 24.0 when they have pressured the QB (80 Pass Attempts) since the 2024 season — best in NFL; League Avg: 56.2.

The 49ers defense has allowed just 8.2 yards per completion (690 yards/84 completions) this season — best in NFL; League Avg: 10.5.

The 49ers defense have allowed 5.9 yards per play with tight coverage this season — 3rd-worst in NFL; League Avg: 3.0.

Los Angeles Rams Defense: Important Stats

49ers RBs have averaged just 1.1 yards after contact per carry this season — worst in NFL. The Rams have allowed just 1.4 yards after contact per carry to RBs this season — 4th-best in NFL.

The 49ers went three and out on 14.6% of their drives last season — 3rd-best in NFL. The Rams forced three and outs on 16.8% of opponent drives last season — 4th-worst in NFL.

The 49ers have thrown for 20+ yards on 82 of 686 attempts since the 2024 season — best in NFL. The Rams allowed 20+ yards on 10.3% of attempts since the 2024 season — T-4th-worst in NFL.

Looking to place a bet on this game with a First Bet Offer up to $1,500? Bet now on Rams vs 49ers and all NFL games with BetMGM

More NFL Betting Predictions:

• Anytime & First Touchdown Scorer Predictions
• Receiving Yards Prop Predictions
• Rushing Yards Prop Predictions
• Passing Yards Prop Predictions
• Receptions Made Prop Predictions
• Rushing Attempts Prop Predictions
• Passing Touchdowns Prop Predictions
• QB Interception Prop Predictions
• Field Goals Made Prop Predictions
• NFL Betting Previews: Every Game

More NFL Odds at BetMGM

Take your football entertainment to the next level with NFL betting at the online sportsbook.

From futures like Chiefs Super Bowl odds, Lions odds to win the division, or Ravens playoff odds, to weekly odds like spreads, moneylines, and over/under totals, there’s something for everyone.

And with the best sportsbook promotions, you could land a welcome offer, sports betting Odds Boost, or a Parlay Boost! You can also check out NFL picks and predictions and updated Super Bowl predictions throughout the year.

Log in to your BetMGM account today — or sign up for a new account via the online sportsbook or BetMGM iOS app or BetMGM Android app — to start betting!