49ers vs Cardinals Prediction, Odds & Best Prop Bets – NFL, Week 11

• The Favorite Team are Favorite Spread point favorites vs the Underdog Team
• Total (Over/Under): 48.5 points
• Watch this game on FOX

The San Francisco 49ers (6-4-0) visit State Farm Stadium to take on the Arizona Cardinals (3-6-0) on Nov. 16. Kickoff is scheduled for 4:05pm EST in Glendale, AZ.

The are betting favorites in this matchup, with the spread sitting at ().

The 49ers vs. Cardinals Over/Under is 48.5 total points for the game.

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49ers vs. Cardinals Odds, Spread, Over/Under

49ers vs. Cardinals Prediction

The winning team model predicts the 49ers will win this game with 57.3% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

49ers vs Cardinals Spread Prediction

Based on recent against-the-spread trends, the model predicts the Cardinals will cover the spread with 54.3% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for 49ers players this game, looking at profitable historical betting trends:

Best 49ers Player Prop Bets Today

• Christian McCaffrey has hit the Longest Rush Under in 9 of his last 10 games (+7.85 Units / 67% ROI)
• Christian McCaffrey has hit the Rushing Yards Under in 10 of his last 13 games (+6.65 Units / 45% ROI)
• Christian McCaffrey has hit the Receiving Yards Over in 10 of his last 13 games (+6.45 Units / 43% ROI)
• Christian McCaffrey has hit the Longest Reception Over in 7 of his last 8 games (+5.95 Units / 66% ROI)
• Kendrick Bourne has hit the Longest Reception Over in his last 5 away games (+5.00 Units / 84% ROI)

And here are some top NFL player prop bets for Cardinals players for this matchup, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today

• Chad Ryland has hit the Field Goals Over in 12 of his last 16 games (+8.00 Units / 45% ROI)
• Trey McBride has hit the Receptions Over in 10 of his last 16 games (+3.10 Units / 16% ROI)
• Marvin Harrison Jr. has hit the Receptions Under in 5 of his last 7 games at home (+2.70 Units / 28% ROI)
• Trey McBride has hit the Longest Reception Under in 5 of his last 7 games (+2.60 Units / 32% ROI)
• Michael Wilson has hit the Longest Reception Under in 6 of his last 9 games (+2.50 Units / 24% ROI)

49ers Best Bets:

• The San Francisco 49ers have hit the 1H Game Total Over in 14 of their last 21 games (+8.20 Units / 33% ROI)
• The San Francisco 49ers have hit the Game Total Over in 14 of their last 21 games (+7.40 Units / 32% ROI)
• The San Francisco 49ers have hit the 2Q Game Total Over in 8 of their last 10 away games (+5.80 Units / 50% ROI)
• The San Francisco 49ers have hit the 3Q Game Total Over in 12 of their last 18 games (+4.85 Units / 22% ROI)
• The San Francisco 49ers have covered the 1Q Spread in 13 of their last 21 games (+3.50 Units / 14% ROI)

Cardinals Best Bets:

• The Arizona Cardinals have hit the 3Q Moneyline in 10 of their last 16 games (+8.70 Units / 40% ROI)
• The Arizona Cardinals have covered the 3Q Spread in 12 of their last 16 games (+8.00 Units / 42% ROI)
• The Arizona Cardinals have hit the 4Q Game Total Over in 6 of their last 7 games at home (+4.70 Units / 58% ROI)
• The Arizona Cardinals have hit the 1H Moneyline in 6 of their last 9 games at home (+4.30 Units / 27% ROI)
• The Arizona Cardinals have hit the 2H Game Total Over in 5 of their last 6 games at home (+3.88 Units / 58% ROI)

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 5-5 (-0.5 Units / -4.55% ROI).

• 49ers are 6-4 when betting on the Moneyline for +3.95 Units / 32.11% ROI
• 49ers are 6-3 when betting the Over for +2.7 Units / 24.55% ROI
• 49ers are 3-6 when betting the Under for -3.6 Units / ROI

Cardinals Against the Spread (ATS) Record

Against the spread this NFL season, the Cardinals are 5-4 (+0.6 Units / 6.06% ROI).

• Cardinals are 3-6 when betting on the Moneyline for -5.7 Units / -35.29% ROI
• Cardinals are 5-4 when betting the Over for +0.6 Units / 6.06% ROI
• Cardinals are 4-5 when betting the Under for -1.5 Units / -15.15% ROI

San Francisco 49ers: Keys to the Game vs. the Arizona Cardinals

The Cardinals have targeted TEs 35% of the time (110 Pass Attempts/318 plays) this season — highest in NFL; League Avg: 22%.

The Cardinals ran 30% of their plays in the red zone in Week 10 — best in NFL; League Avg: 13%.

The Cardinals ran 40% of their plays in the red zone in the 2nd half in Week 10 — best in NFL; League Avg: 16%.

The Cardinals have turned the ball over on downs 4 times in the red zone this season — T-2nd-most in NFL.

Arizona Cardinals: Keys to the Game vs. the San Francisco 49ers

The 49ers have run 723 plays this season — most in NFL.

The 49ers have targeted RBs 26% of the time (106 Pass Attempts/411 plays) this season — highest in NFL; League Avg: 17%.

The 49ers have started 9 drives inside their own 10 yard line in the 2nd half this season — T-most in NFL.

The 49ers have averaged 307.9 passing yards per game (3,079/10) this season — best in NFL; League Avg: 235.1.

Additional Matchup Notes for San Francisco 49ers vs. Arizona Cardinals

The 49ers have run 723 plays this season — most in NFL.

The 49ers have targeted RBs 26% of the time (106 Pass Attempts/411 plays) this season — highest in NFL; League Avg: 17%.

The 49ers have started 9 drives inside their own 10 yard line in the 2nd half this season — T-most in NFL.

The 49ers have averaged 307.9 passing yards per game (3,079/10) this season — best in NFL; League Avg: 235.1.

The Cardinals have targeted TEs 35% of the time (110 Pass Attempts/318 plays) this season — highest in NFL; League Avg: 22%.

The Cardinals ran 30% of their plays in the red zone in Week 10 — best in NFL; League Avg: 13%.

The Cardinals ran 40% of their plays in the red zone in the 2nd half in Week 10 — best in NFL; League Avg: 16%.

The Cardinals have turned the ball over on downs 4 times in the red zone this season — T-2nd-most in NFL.

San Francisco 49ers Offense: Important Stats

The Cardinals have targeted TEs 35% of the time (110 Pass Attempts/318 plays) this season — highest in NFL; League Avg: 22%.

The Cardinals ran 30% of their plays in the red zone in Week 10 — best in NFL; League Avg: 13%.

The Cardinals ran 40% of their plays in the red zone in the 2nd half in Week 10 — best in NFL; League Avg: 16%.

The Cardinals have turned the ball over on downs 4 times in the red zone this season — T-2nd-most in NFL.

Arizona Cardinals Offense: Important Stats

The 49ers have run 723 plays this season — most in NFL.

The 49ers have targeted RBs 26% of the time (106 Pass Attempts/411 plays) this season — highest in NFL; League Avg: 17%.

The 49ers have started 9 drives inside their own 10 yard line in the 2nd half this season — T-most in NFL.

The 49ers have averaged 307.9 passing yards per game (3,079/10) this season — best in NFL; League Avg: 235.1.

San Francisco 49ers Defense: Important Stats

The Cardinals have targeted TEs 35% of the time (110 Pass Attempts/318 plays) this season — highest in NFL; League Avg: 22%.

The Cardinals ran 30% of their plays in the red zone in Week 10 — best in NFL; League Avg: 13%.

The Cardinals ran 40% of their plays in the red zone in the 2nd half in Week 10 — best in NFL; League Avg: 16%.

The Cardinals have turned the ball over on downs 4 times in the red zone this season — T-2nd-most in NFL.

Arizona Cardinals Defense: Important Stats

The 49ers have run 723 plays this season — most in NFL.

The 49ers have targeted RBs 26% of the time (106 Pass Attempts/411 plays) this season — highest in NFL; League Avg: 17%.

The 49ers have started 9 drives inside their own 10 yard line in the 2nd half this season — T-most in NFL.

The 49ers have averaged 307.9 passing yards per game (3,079/10) this season — best in NFL; League Avg: 235.1.

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More NFL Betting Predictions:

• Anytime & First Touchdown Scorer Predictions
• Receiving Yards Prop Predictions
• Rushing Yards Prop Predictions
• Passing Yards Prop Predictions
• Receptions Made Prop Predictions
• Rushing Attempts Prop Predictions
• Passing Touchdowns Prop Predictions
• QB Interception Prop Predictions
• Field Goals Made Prop Predictions
• NFL Betting Previews: Every Game

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