49ers vs Browns Prediction, Odds & Best Prop Bets – NFL, Week 13

BetMGM Betting Nov 30, 2025, 9:56 AM

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FILE - Huntington Bank Field during an NFL football game between the Cleveland Browns and the New York Giants, Sept. 22, 2024, in Cleveland. (AP Photo/Kirk Irwin, File)

(AP Photo/Kirk Irwin, File)

The Favorite Team are Favorite Spread point favorites vs the Underdog Team
Total (Over/Under): 38 points
Watch this game on CBS

The San Francisco 49ers (8-4-0) visit Huntington Bank Field to take on the Cleveland Browns (3-8-0) on Nov. 30. Kickoff is scheduled for 1:00pm EST in Cleveland, OH.

The are betting favorites in this matchup, with the spread sitting at ().

The 49ers vs. Browns Over/Under is 38 total points for the game.

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49ers vs. Browns Odds, Spread, Over/Under

	Spread	Total (O/U)	Moneyline
49ers	+49 -110	38 -110	-250
Browns	+5.5 -110	38 -110	200

49ers vs. Browns Prediction

The winning team model predicts the 49ers will win this game with 70.9% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

49ers vs Browns Spread Prediction

Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread with 59.2% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for 49ers players this game, looking at profitable historical betting trends:

Best Browns Player Prop Bets Today

Quinshon Judkins has hit the Rushing Yards Under in his last 6 games (+6.00 Units / 90% ROI)
Harold Fannin Jr. has hit the Longest Reception Over in his last 6 games (+6.00 Units / 85% ROI)
Cedric Tillman has hit the Receiving Yards Under in 5 of his last 6 games (+3.90 Units / 57% ROI)
Quinshon Judkins has hit the Receiving Yards Under in 5 of his last 6 games (+3.85 Units / 56% ROI)
Cedric Tillman has hit the Longest Reception Under in 5 of his last 6 games (+3.85 Units / 55% ROI)

And here are some top NFL player prop bets for Browns players for this matchup, looking at profitable historical betting trends:

Best 49ers Player Prop Best Bets Today

Christian McCaffrey has hit the Receiving Yards Over in 10 of his last 13 games (+6.50 Units / 43% ROI)
Christian McCaffrey has hit the Longest Reception Over in 8 of his last 10 games (+5.85 Units / 51% ROI)
Brian Robinson has hit the Receiving Yards Under in 9 of his last 12 games (+5.70 Units / 40% ROI)
Christian McCaffrey has hit the Longest Rush Under in 9 of his last 12 games (+5.60 Units / 40% ROI)
Kendrick Bourne has hit the Longest Reception Over in his last 5 away games (+5.00 Units / 84% ROI)

Browns Best Bets:

The Cleveland Browns have covered the 2Q Spread in 5 of their last 7 games at home (+3.90 Units / 48% ROI)
The Cleveland Browns have hit the 2Q Moneyline in 4 of their last 7 games at home (+3.35 Units / 45% ROI)
The Cleveland Browns have hit the 4Q Game Total Under in 5 of their last 7 games at home (+2.75 Units / 35% ROI)
The Cleveland Browns have covered the 3Q Spread in 5 of their last 7 games at home (+2.50 Units / 29% ROI)
The Cleveland Browns have covered the 1H Spread in 5 of their last 8 games at home (+1.55 Units / 17% ROI)

49ers Best Bets:

The San Francisco 49ers have hit the 1H Game Total Over in 14 of their last 21 games (+9.30 Units / 40% ROI)
The San Francisco 49ers have hit the Game Total Over in 14 of their last 21 games (+8.50 Units / 39% ROI)
The San Francisco 49ers have hit the 2Q Game Total Over in 8 of their last 10 away games (+5.80 Units / 50% ROI)
The San Francisco 49ers have covered the 1Q Spread in 14 of their last 21 games (+4.70 Units / 19% ROI)
The San Francisco 49ers have hit the Moneyline in 6 of their last 11 away games (+4.25 Units / 32% ROI)

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 7-5 (+0.5 Units / 4.13% ROI).

49ers are 8-4 when betting on the Moneyline for +4.95 Units / 34.98% ROI
49ers are 7-4 when betting the Over for +3.7 Units / 30.58% ROI
49ers are 4-7 when betting the Under for -4.7 Units / ROI

Browns Against the Spread (ATS) Record

Against the spread this NFL season, the Browns are 5-6 (-1.6 Units / -13.22% ROI).

Browns are 3-8 when betting on the Moneyline for -2.5 Units / -21.37% ROI
Browns are 6-5 when betting the Over for +0.5 Units / 4.13% ROI
Browns are 5-6 when betting the Under for -1.6 Units / -13.22% ROI

San Francisco 49ers: Keys to the Game vs. the Cleveland Browns

The Browns have run successful plays on 40% of plays on first read passes this season — worst in NFL; League Avg: 52%.

The Browns have run successful plays on 32% of plays this season — worst in NFL; League Avg: 43%.

The Browns have gained at least 5 yards on 30% of first down plays this season — worst in NFL; League Avg: 43%.

The Browns have run successful plays on 39% of pass attempts on first read passes this season — worst in NFL; League Avg: 52%.

Cleveland Browns: Keys to the Game vs. the San Francisco 49ers

The 49ers have targeted RBs 27% of the time (113 Pass Attempts/420 plays) this season — highest in NFL; League Avg: 17%.

The 49ers have run 60% of their plays in their opponent’s territory in the 2nd half this season — 2nd-best in NFL; League Avg: 49%.

The 49ers have faced a blitz just 8% of the time this season — lowest in NFL; League Avg: 13%.

The 49ers have run successful plays on 73% of plays on first read passes since Week 9 — best in NFL; League Avg: 51%.

Additional Matchup Notes for San Francisco 49ers vs. Cleveland Browns