The most points scored by the Buffalo Bills in a game is 58 points. They beat the Miami Dolphins 58-24 in 1966.
Highest-Scoring Bills Games
1. Bills 58, Dolphins 24 – 1966
Buffalo posted four total rushing touchdowns, with two courtesy of Bobby Burnett (64 rushing yards) in this 34-point victory.
2. Bills 56, Dolphins 26 – 2021
The Bills outscored Miami 28-3 in the second quarter to cap off the blowout, and Josh Allen contributed 224 passing yards and three touchdowns.
3. Bills 54, Chiefs 31 – 2008
Trent Edwards had a solid day at quarterback, throwing for 273 yards and posting four total touchdowns (two passing and two rushing) in a matchup where Kansas City led 14-10 in the second quarter.
4. Bills 52, Steelers 34 – 1991
The quarterback-receiver duo of Jim Kelly (363 passing yards and six touchdowns) and Don Beebe (112 receiving yards and four touchdowns) kept the Steelers at bay in this home win.
5. Bills 51, Bengals 24 – 1979
Despite the game being tied at 10 at halftime, Roland Hooks rushed for 70 yards and four touchdowns in Buffalo’s eventual victory.
6. Bills 50, Chiefs 17 – 1976
Some standout performances from this Buffalo home matchup came from O.J. Simpson (130 rushing yards and two touchdowns), Jeff Kinney (114 rushing yards and a touchdown), and Bob Chandler (59 receiving yards and three touchdowns).
7. Bills 49, Bengals 31 – 2010
In a dominant offensive effort, Ryan Fitzpatrick threw for 316 yards and four touchdowns, Fred Jackson rushed for 116 yards and two touchdowns, and Stevie Johnson recorded 137 yards and three touchdowns.
8. Bills 48, Lions 42 – 2024
Buffalo led the entire game, with the quarterback-running back duo of Josh Allen (362 passing yards and four total touchdowns) and James Cook (105 rushing yards and two touchdowns) leading the charge.
8. Bills 48, Dolphins 20 – 2023
Once again, Josh Allen was spectacular, throwing for 320 yards and ending with five total touchdowns (four passing and one receiving).
Stefon Diggs also was lethal in the passing game, finishing with 120 receiving yards and three touchdowns.
8. Bills 48, Broncos 19 – 2020
In a road showdown in Denver, Josh Allen threw for 359 yards and tallied four total touchdowns (two passing and two rushing) in this 29-point victory.
8. Bills 48, Oilers 17 – 1964
Jack Kemp threw for 378 yards and three touchdowns (with three interceptions), Cookie Gilchrist recorded 140 scrimmage yards with two rushing touchdowns, and the duo of Glenn Bass/Elbert Dubenion ended with a combined 330 receiving yards and three total touchdowns.
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