Brewers vs. Yankees Prediction & Odds for Opening Day

MLB’s 14-game slate on Opening Day will begin with a nationally televised matchup between the Milwaukee Brewers and New York Yankees at 3:05 p.m. ET on Thursday at Yankee Stadium. The game will be broadcast on ESPN.

The Yankees enter the 2025 season as American League favorites following last year’s World Series appearance, though they have dealt with more injuries than most this spring. Gerrit Cole, the team’s ace, is out for the year while recovering from Tommy John surgery.

Milwaukee hopes to continue surprising everyone this year. The Brewers aren’t favored to win the National League Central, despite finishing atop the division in back-to-back years. They have made the playoffs six times over the last seven years.

Here’s a look at the latest MLB betting odds and my Brewers vs. Yankees prediction ahead of Opening Day.

Brewers vs. Yankees Odds: Thursday, March 27

• Brewers moneyline: +130
• Yankees moneyline: -155
• Game total: 8 (-102/-118)

Brewers vs. Yankees Opening Day Starting Pitchers

Freddy Peralta has been named the starting pitcher for the Milwaukee Brewers on Opening Day. He beat the New York Mets in his first career Opening Day start last season.

Cole was in line to start for the Yankees, but Carlos Rodón has been announced as the new Opening Day starter. Max Fried, who signed a $218 million deal in the offseason, will get the ball later in the series.

• Brewers starting pitcher: Freddy Peralta
• Yankees starting pitcher: Carlos Rodón

Brewers vs. Yankees Prediction for Opening Day

Based on the latest MLB odds, I’m taking Milwaukee’s moneyline (+145) as my Brewers vs. Yankees prediction for Opening Day.

I’m surprised the odds for this game didn’t move following the news of Cole’s injury, particularly considering how the market reacted with the Yankees’ futures odds.

The Yankees’ win total dropped to 88.5 after opening at 93.5 earlier in the offseason. Their World Series price went from +800 to +900, while their AL East odds climbed from +105 to +165.

In addition, New York’s odds to miss the playoffs went from +310 to +180.

The market indicates that the Yankees shouldn’t be priced as the clear AL favorites.

Of course, the concern about the Yankees is their depth, which won’t matter as much in Game 1. But I also like backing Peralta at this +145 price tag.

Peralta spun a 3.68 ERA in 32 starts last year, striking out 200 batters in 173 2/3 innings. He’s moved back to the third-base side of the mound in hopes of regaining some extension in his delivery.

Peralta limited hitters to a 7.6% barrel rate over his final 10 starts last year, suggesting he’s up to the challenge of holding down the Yankees’ lineup on Opening Day.

Brewers vs. Yankees Prediction: Brewers Moneyline (+145)

• Pick made on March 18.

How to Watch Brewers vs. Yankees on Opening Day

Watch Brewers vs. Yankees on Opening Day on ESPN at 3:05 p.m. ET on Thursday, March 27.

• Date: Thursday, March 27
• Time: 3:05 p.m. ET
• Location: Yankee Stadium (New York)
• TV info: ESPN

Brewers 2025 Schedule

Yankees 2025 Schedule