Wyoming vs Colorado Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 4

Colorado head coach Deion Sanders in the first half of the team's spring practice NCAA college football game Saturday, April 22, 2023, in Boulder, Colo.
(AP Photo/David Zalubowski)
  • Colorado is a -13.5 point favorite vs. Wyoming
  • Wyoming vs. Colorado Total (Over/Under): 44.5 points
  • TV Channel: ESPN

Wyoming (2-1) visit Folsom Field to take on Colorado (1-2) on Sep. 20 in Boulder, CO. Kickoff is scheduled for 10:15pm EDT.

Colorado is a betting favorite in Week 4, with the spread sitting at -13.5 (-105).

The Wyoming vs. Colorado Over/Under is 44.5 total points.

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Wyoming vs. Colorado Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Wyoming+13.5 -11544.5 -115375
Colorado -13.5 -10544.5 -105-500

Wyoming vs Colorado Prediction:

The winning team model predicts Colorado will win this game with 77.6% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Wyoming and Colorado, key player performances this season and recent team trends.

Wyoming vs Colorado Spread Prediction:

Based on recent against-the-spread trends, the model predicts Colorado will cover the spread with 57.6% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • Wyoming has hit the Moneyline in 3 of their last 6 away games (+7.05 Units / 100% ROI)
  • Wyoming has hit the 1Q Game Total Under in 8 of their last 12 games (+4.56 Units / 33% ROI)
  • Wyoming has hit the Game Total Under in 8 of their last 12 games (+3.60 Units / 27% ROI)
  • Wyoming have covered the Spread in 8 of their last 12 games (+3.60 Units / 27% ROI)
  • Wyoming has hit the 1H Game Total Under in 4 of their last 6 away games (+1.75 Units / 26% ROI)
  • Colorado have covered the 1Q Spread in 6 of their last 8 games at home (+5.05 Units / 55% ROI)
  • Colorado has hit the Moneyline in 8 of their last 13 games (+4.80 Units / 10% ROI)
  • Colorado have covered the Spread in 9 of their last 13 games (+4.60 Units / 32% ROI)
  • Colorado has hit the 1Q Moneyline in 6 of their last 7 games at home (+4.60 Units / 26% ROI)
  • Colorado has hit the 1H Game Total Under in 5 of their last 8 games at home (+1.60 Units / 18% ROI)

Wyoming Against the Spread (ATS) Record

Wyoming is 2-1 against the spread this college football season (+0.9 Units / 27.27% ROI).

  • Wyoming is 2-1 when betting on the Moneyline for +1 Units / 11.05% ROI
  • Wyoming is 0-3 when betting the Over for -3.3 Units / -100% ROI
  • Wyoming is 3-0 when betting the Under for +3 Units / 90.91% ROI

Colorado Against the Spread (ATS) Record

Colorado iss 1-2 against the spread this college football season (-1.2 Units / -36.36% ROI).

  • Colorado is 1-2 when betting on the Moneyline for -1 Units / -4.17% ROI
  • Colorado is 1-2 when betting the Over for -1.2 Units / -36.36% ROI
  • Colorado is 2-1 when betting the Under for +0.9 Units / 27.27% ROI

Wyoming: Keys to the Game vs. Colorado

Wyoming is winless (0-7) when allowing 200 or more passing yards since the 2024 season– T-worst among Non-Power Conference Teams; Average: .439

Wyoming was winless (0-6) when allowing 200 or more passing yards last season– T-worst in FBS; Average: .481

Wyoming was winless (0-6) when allowing 200 or more passing yards last season– T-worst among Non-Power Conference Teams; Average: .462

Wyoming was 3-9 (.250) when allowing 10 or more rushes of four or more yards last season– T-19th-worst in FBS; Average: .479

Colorado: Keys to the Game vs. Wyoming

Colorado was 4-3 (.571) when sacking the QB less than 3 times last season– T-36th-best in FBS; Average: .429

Colorado was 6-1 (.857) when averaging more than 5 yards on first down plays last season– 7th-best among Power Conference Teams; Average: .632

Colorado is 2-5 (.286) when not forcing and recovering a fumble since the 2024 season– 7th-worst among Power Conference Teams; Average: .534

Colorado was 2-4 (.333) when not forcing and recovering a fumble last season– T-13th-worst among Power Conference Teams; Average: .492

Matchup Notes for Wyoming vs. Colorado

Colorado has gained 630 yards on 58 receptions (just 10.9 YPR) this season — T-3rd-worst among Big 12 skill players. Wyoming’s defense has allowed just 8.1 Yards Per Reception this season — 9th-best among FBS defenses.

Colorado’s TEs has gained 26 yards on 4 receptions (just 6.5 YPR) this season — worst among Big 12 TEs. Wyoming’s defense has allowed just 8.1 Yards Per Reception this season — 9th-best among FBS defenses.

Colorado’s TEs has gained 26 yards on 4 receptions (just 6.5 YPR) this season — 5th-worst among P5 TEs. Wyoming’s defense has allowed just 8.1 Yards Per Reception this season — 9th-best among FBS defenses.

Wyoming has 231 receptions in 15 games (just 15.4 per game) since the 2024 season — 22nd-worst among FBS skill players. Colorado’s defense has allowed just 17.1 receptions per game since the 2024 season — 5th-best among Big 12 defenses.

Wyoming has 231 receptions in 15 games (just 15.4 per game) since the 2024 season — 22nd-worst among FBS skill players. Colorado’s defense has allowed just 17.1 receptions per game since the 2024 season — T-32nd-best among FBS defenses.

Wyoming’s WRs has 146 receptions in 15 games (just 9.7 per game) since the 2024 season — 27th-worst among FBS WRs. Colorado’s defense has allowed just 17.1 receptions per game since the 2024 season — 5th-best among Big 12 defenses.

Wyoming Offensive Stats & Trends

Wyoming has 231 receptions in 15 games (just 15.4 per game) since the 2024 season — 22nd-worst among FBS skill players. Colorado’s defense has allowed just 17.1 receptions per game since the 2024 season — 5th-best among Big 12 defenses.

Wyoming QBs have 4 completions for 20 or more yards with over 10 yards to go this season– T-3rd-most among FBS Teams

Wyoming has 231 receptions in 15 games (just 15.4 per game) since the 2024 season — 22nd-worst among FBS skill players. Colorado’s defense has allowed just 17.1 receptions per game since the 2024 season — T-32nd-best among FBS defenses.

Wyoming’s WRs has 146 receptions in 15 games (just 9.7 per game) since the 2024 season — 27th-worst among FBS WRs. Colorado’s defense has allowed just 17.1 receptions per game since the 2024 season — 5th-best among Big 12 defenses.

Wyoming’s WRs has 146 receptions in 15 games (just 9.7 per game) since the 2024 season — 27th-worst among FBS WRs. Colorado’s defense has allowed just 10.2 receptions per game to WRs since the 2024 season — T-16th-best among FBS defenses.

Colorado Offensive Stats & Trends

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among FBS Teams; Average: 12.3

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among Power Conference Teams; Average: 12.6

Colorado TEs averaged just 6.7 yards per reception (67 yards/10 catches) last season– worst among Big 12 Teams; Average: 11.1

Colorado have averaged 21.4 yards per completion (257 yards/12 completions) on 3rd down this season– 4th-best among FBS Offenses; Average: 11.7

Colorado WRs had 40 receptions in the Red Zone last season– most among Power Conference Teams

Wyoming Defensive Stats & Trends

Wyoming has allowed passes of 20+ yards on just 3 of 108 attempts (3%) this season– 2nd-best among Non-Power Conference Teams; Average: 10%

Wyoming has allowed first downs on 10% of pass attempts on 3rd and long since the 2024 season– best among Non-Power Conference Teams; Average: 27%

Wyoming allowed first downs on 19% of pass attempts on 3rd down last season– best among Non-Power Conference Teams; Average: 35%

Wyoming has allowed a Completion Pct of just 41% (26 completions/63 attempts) on 3rd and long since the 2024 season– T-2nd-best in FBS; Average: 54%

Wyoming allowed first downs on 11% of pass attempts on 3rd and long last season– best in FBS; Average: 28%

Colorado Defensive Stats & Trends

Colorado sacked opposing QBs on 10% of pass attempts (39/391) last season– best in the Big 12; Average: 6%

Colorado has allowed a Completion Pct of just 15% (2 completions/13 attempts) on 3rd and long this season– 2nd-best among Power Conference Teams; Average: 54%

Colorado sacked opponents 39 times last season– most in the Big 12

Colorado has allowed a Completion Pct of just 15% (2 completions/13 attempts) on 3rd and long this season– best in the Big 12; Average: 54%

Colorado averaged 3.0 sacks per game last season– best in the Big 12; Average: 1.9


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