Vanderbilt vs Alabama Prediction, Odds & Best Prop Bets – NCAAF, Week 6

BetMGM Betting Oct 02, 2025, 2:53 PM

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Alabama head coach Kalen DeBoer watches warm-ups before an NCAA college football game against Western Kentucky, Saturday, Aug. 31, 2024, in Tuscaloosa, Ala.

(AP Photo/Vasha Hunt)

Alabama is a -10.5 point favorite vs. Vanderbilt
Vanderbilt vs. Alabama Total (Over/Under): 55.5 points
TV Channel: ABC

Vanderbilt (5-0) visit Bryant-Denny Stadium to take on Alabama (3-1) on Oct. 4 in Tuscaloosa, AL. Kickoff is scheduled for 3:30pm EDT.

Alabama is a betting favorite in Week 6, with the spread sitting at -10.5 (-110).

The Vanderbilt vs. Alabama Over/Under is 55.5 total points.

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Vanderbilt vs. Alabama Odds, Spread, Over/Under:

	Spread	Total (O/U)	Moneyline
Vanderbilt	+10.5 -110	55.5 -110	325
Alabama	-10.5 -110	55.5 -110	-425

Vanderbilt vs Alabama Prediction:

The winning team model predicts Alabama will win this game with 75.3% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Vanderbilt and Alabama, key player performances this season and recent team trends.

Vanderbilt vs Alabama Spread Prediction:

Based on recent against-the-spread trends, the model predicts Vanderbilt will cover the spread with 51.1% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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Vanderbilt Best Bets Today

Vanderbilt has hit the Moneyline in 9 of their last 13 games (+19.10 Units / 18% ROI)
Vanderbilt has hit the 1H Moneyline in 8 of their last 13 games (+10.25 Units / 7% ROI)
Vanderbilt have covered the Spread in 10 of their last 14 games (+5.60 Units / 36% ROI)
Vanderbilt has hit the Team Total Over in their last 5 games (+5.00 Units / 86% ROI)
Vanderbilt have covered the 1Q Spread in 9 of their last 13 games (+4.00 Units / 25% ROI)

Alabama Best Bets Today

Alabama has hit the 1Q Moneyline in their last 5 games at home (+5.00 Units / 15% ROI)
Alabama has hit the 1H Moneyline in their last 5 games at home (+5.00 Units / 7% ROI)
Alabama have covered the Spread in 5 of their last 6 games at home (+3.90 Units / 59% ROI)
Alabama have covered the 1H Spread in 4 of their last 5 games at home (+2.85 Units / 49% ROI)
Alabama has hit the 1H Game Total Under in 4 of their last 5 games at home (+2.80 Units / 48% ROI)

Vanderbilt Against the Spread (ATS) Record

Vanderbilt is 4-1 against the spread this college football season (+2.9 Units / 52.73% ROI).

Vanderbilt is 4-0 when betting on the Moneyline for +4.45 Units / 7.3% ROI
Vanderbilt is 3-2 when betting the Over for +0.8 Units / 14.55% ROI
Vanderbilt is 2-3 when betting the Under for -1.3 Units / -23.64% ROI

Alabama Against the Spread (ATS) Record

Alabama iss 3-1 against the spread this college football season (+1.9 Units / 43.18% ROI).

Alabama is 2-1 when betting on the Moneyline for -3.35 Units / -20.3% ROI
Alabama is 3-1 when betting the Over for +1.9 Units / 43.18% ROI
Alabama is 1-3 when betting the Under for -2.3 Units / -52.27% ROI

Vanderbilt: Keys to the Game vs. Alabama

Alabama is undefeated (10-0) when rushing for more than 100 yards since the 2024 season– T-best among Power Conference Teams; Average: .709

Alabama was 8-1 (.889) when making 7 or more explosive plays last season– T-8th-best among Power Conference Teams; Average: .659

Alabama was 6-3 (.667) when sacking the QB less than 3 times last season– T-19th-best in FBS; Average: .429

Alabama was 8-1 (.889) when making 7 or more explosive plays last season– T-14th-best in FBS; Average: .628

Alabama: Keys to the Game vs. Vanderbilt

Alabama Skill Players averaged 20.7 yards per reception (497 yards/24 catches) on 3rd and long last season– best among Power Conference Teams; Average: 13.1

Alabama WRs have averaged 25.4 yards per reception (458 yards/18 catches) on 3rd and long since the 2024 season– best among Power Conference Teams; Average: 14.8

Alabama WRs averaged 29.0 yards per reception (348 yards/12 catches) on 3rd and long last season– best among Power Conference Teams; Average: 14.8

Alabama WRs have averaged 25.4 yards per reception (458 yards/18 catches) on 3rd and long since the 2024 season– best among FBS Teams; Average: 14.5

Alabama Skill Players averaged 20.7 yards per reception (497 yards/24 catches) on 3rd and long last season– best among FBS Teams; Average: 12.9

Matchup Notes for Vanderbilt vs. Alabama