USC vs Purdue Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 3

Purdue fans during an NCAA football game against the Penn State on Thursday, Sept. 1, 2022, in West Lafayette, Ind. (AP Photo/Doug McSchooler)
(AP Photo/Doug McSchooler)
  • USC is a -20.5 point favorite vs. Purdue
  • USC vs. Purdue Total (Over/Under): 58.5 points
  • TV Channel: CBS | PAR+

USC (2-0) visit Ross-Ade Stadium to take on Purdue (2-0) on Sep. 13 in West Lafayette, IN. Kickoff is scheduled for 3:30pm EDT.

USC is a betting favorite in Week 3, with the spread sitting at -20.5 (-110).

The USC vs. Purdue Over/Under is 58.5 total points.

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USC vs. Purdue Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
USC-20.5 -11058.5 -105-1600
Purdue +20.5 -11058.5 -115900

USC vs Purdue Prediction:

The winning team model predicts USC will win this game with 84.9% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both USC and Purdue, key player performances this season and recent team trends.

USC vs Purdue Spread Prediction:

Based on recent against-the-spread trends, the model predicts USC will cover the spread with 55.2% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • USC has hit the 1Q Game Total Under in their last 5 away games (+5.00 Units / 82% ROI)
  • USC has hit the 1H Game Total Under in 5 of their last 6 away games (+5.00 Units / 74% ROI)
  • USC has hit the Game Total Over in 9 of their last 13 games (+4.60 Units / 32% ROI)
  • USC have covered the Spread in 8 of their last 13 games (+2.50 Units / 17% ROI)
  • USC have covered the 1H Spread in 8 of their last 13 games (+2.40 Units / 16% ROI)
  • Purdue has hit the 1Q Game Total Over in 4 of their last 6 games at home (+2.85 Units / 40% ROI)
  • Purdue has hit the 1H Game Total Under in 4 of their last 6 games at home (+1.70 Units / 25% ROI)
  • Purdue has hit the Game Total Under in 4 of their last 7 games at home (+0.70 Units / 9% ROI)

USC Against the Spread (ATS) Record

USC is 2-0 against the spread this college football season (+2 Units / 90.91% ROI).

  • USC is 1-0 when betting on the Moneyline for +1 Units / 2.5% ROI
  • USC is 2-0 when betting the Over for +2 Units / 90.91% ROI
  • USC is 0-2 when betting the Under for -2.2 Units / -100% ROI

Purdue Against the Spread (ATS) Record

Purdue iss 1-1 against the spread this college football season (-0.1 Units / -4.55% ROI).

  • Purdue is 2-0 when betting on the Moneyline for +2 Units / 11.11% ROI
  • Purdue is 0-2 when betting the Over for -2.2 Units / -100% ROI
  • Purdue is 2-0 when betting the Under for +2 Units / 90.91% ROI

USC: Keys to the Game vs. Purdue

USC is undefeated (6-0) when rushing more than 30 times since the 2024 season– T-best among Power Conference Teams; Average: .682

USC is 6-3 (.667) when committing less than 60 yards in penalties since the 2024 season– T-31st-best in FBS; Average: .528

USC was 2-5 (.250) when not forcing a fumble in the 2023 season– T-11th-worst among Power Conference Teams; Average: .513

Purdue: Keys to the Game vs. USC

Purdue was winless (0-4) when in a one score game last season– T-worst among Power Conference Teams; Average: .514

Purdue was winless (0-8) when averaging less than 5 yards per rush last season– T-worst among Power Conference Teams; Average: .462

Purdue was 1-8 (.111) when their opponent committed less than 60 yards in penalties last season– worst among Power Conference Teams; Average: .581

Purdue was winless (0-7) when throwing at least 1 interception last season– T-worst among Power Conference Teams; Average: .443

Matchup Notes for USC vs. Purdue

Purdue’s WRs has 118 receptions in 14 games (just 8.4 per game) since the 2024 season — T-11th-worst among FBS WRs. USC’s defense has allowed 22.7 receptions per game since the 2024 season — 2nd-worst among P5 defenses.

Purdue’s WRs has 118 receptions in 14 games (just 8.4 per game) since the 2024 season — 4th-worst among Big Ten WRs. USC’s defense has allowed 22.7 receptions per game since the 2024 season — 2nd-worst among P5 defenses.

Purdue has 222 receptions in 14 games (just 15.9 per game) since the 2024 season — 3rd-worst among Big Ten skill players. USC’s defense has allowed 22.7 receptions per game since the 2024 season — 2nd-worst among FBS defenses.

USC’s WRs has 270 receptions in 15 games (18.0 per game) since the 2024 season — 4th-best among Power 5 WRs. Purdue’s defense has allowed just 9.7 receptions per game to WRs since the 2024 season — T-10th-best among FBS defenses.

USC’s offense has thrown for 810 passing yards in 2 games (405.0 YPG) this season — 3rd-best among FBS offenses. Purdue’s defense has allowed just 144.5 passing yards per game this season — 29th-best among FBS defenses.

USC’s WRs has 270 receptions in 15 games (18.0 per game) since the 2024 season — best among Big Ten WRs. Purdue’s defense has allowed just 9.7 receptions per game to WRs since the 2024 season — T-10th-best among FBS defenses.

USC Offensive Stats & Trends

USC TEs had no touchdowns on 5 receptions in the Red Zone last season– T-worst Receptions Per TD among Power Conference Teams; Average: 2.0

USC TEs had no touchdowns on 33 receptions last season– T-worst Receptions Per TD among FBS Teams; Average: 9.6

USC TEs have gained no yards on 1 receptions (0.0 YPR) on 3rd and long since the 2024 season– worst among Big Ten Teams; Average: 11.0

USC WRs caught 9 touchdown passes in the 4th quarter last season– most among Big Ten Teams

USC TEs had no touchdowns on 33 receptions last season– worst Receptions Per TD among Power Conference Teams; Average: 10.3

Purdue Offensive Stats & Trends

Purdue’s WRs has 118 receptions in 14 games (just 8.4 per game) since the 2024 season — T-11th-worst among FBS WRs. USC’s defense has allowed 22.7 receptions per game since the 2024 season — 2nd-worst among P5 defenses.

Purdue’s WRs has 118 receptions in 14 games (just 8.4 per game) since the 2024 season — 4th-worst among Big Ten WRs. USC’s defense has allowed 22.7 receptions per game since the 2024 season — 2nd-worst among P5 defenses.

Purdue has 222 receptions in 14 games (just 15.9 per game) since the 2024 season — 3rd-worst among Big Ten skill players. USC’s defense has allowed 22.7 receptions per game since the 2024 season — 2nd-worst among FBS defenses.

Purdue’s TEs has 4 receptions in 2 games (just 2.0 per game) this season — T-2nd-worst among Big Ten TEs. USC’s defense has allowed 22.0 receptions per game this season — T-25th-worst among FBS defenses.

Purdue’s WRs has 118 receptions in 14 games (just 8.4 per game) since the 2024 season — T-11th-worst among FBS WRs. USC’s defense has allowed 22.7 receptions per game since the 2024 season — worst among Big Ten defenses.

USC Defensive Stats & Trends

USC did not allow an opponent to rush for 10 or more yards on any of their 12 carries on 3rd and long last season– T-best in the Big Ten; Average: 14%

USC did not allow an opponent to rush for 10 or more yards on any of their 12 carries on 3rd and long last season– T-best in FBS; Average: 18%

USC allowed a Completion Pct of 68% (296 completions/436 attempts) last season– worst in the Big Ten; Average: 61%

USC allowed a Completion Pct of 100% (9 completions/9 attempts) on 3rd and short in the 2023 season– worst in the Big Ten; Average: 60%

USC allowed 4.4 touchdowns per interception (31 TDs allowed, and 7 INT) in the 2023 season– worst in the Big Ten; Average: 1.6

Purdue Defensive Stats & Trends

Purdue allowed 6.8 touchdowns per interception (27 TDs allowed, and 4 INT) last season– worst in the Big Ten; Average: 1.6

Purdue allowed 60 TDs last season– worst in the Big Ten; Average: 2.6

Purdue has sacked opposing QBs on 25% of pass attempts (4/16) this season– 2nd-best among Power Conference Teams; Average: 7%

Purdue has intercepted 4 of 380 attempts (95.0 pass attempts per int.) since the 2024 season– worst in the Big Ten; Average: 35.2

Purdue allowed 13.9 yards per completion (3,032 yards/218 completions) last season– worst in the Big Ten; Average: 11.0


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