Tulane vs Mississippi Prediction, Odds & Best Prop Bets – College Football Playoffs

BetMGM Betting Dec 19, 2025, 5:19 PM

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Mississippi coach Lane Kiffin watches a play on the video board during the second half of the team's NCAA college football game against Central Arkansas in Oxford, Miss., Saturday, Sept. 10, 2022. (AP Photo/Rogelio V. Solis)

(AP Photo/Rogelio V. Solis)

Mississippi is a -17.5 point favorite vs. Tulane
Tulane vs. Ole Miss Total (Over/Under): 56.5 points
TV Channel: TNT | HBOM

Tulane (11-2) visit Vaught-Hemingway Stadium to take on Ole Miss (11-1) on Dec. 20 in University, MS. Kickoff is scheduled for 3:30pm EST.

Mississippi is a betting favorite in the College Football Playoffs, with the spread sitting at -17.5 (-110).

The Tulane vs. Ole Miss Over/Under is 56.5 total points.

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Tulane vs. Ole Miss Odds, Spread, Over/Under:

	Spread	Total (O/U)	Moneyline
Tulane	+17.5 -110	56.5 -110	600
Ole Miss	-17.5 -110	56.5 -110	-900

Tulane vs Ole Miss Prediction:

The winning team model predicts Ole Miss will win this game with 77.6% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Tulane and Mississippi, key player performances this season and recent team trends.

Tulane vs Ole Miss Spread Prediction:

Based on recent against-the-spread trends, the model predicts Tulane will cover the spread with 54.3% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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Tulane Best Bets Today

Tulane have covered the 1H Spread in 11 of their last 14 games (+7.35 Units / 44% ROI)
Tulane has hit the 1H Moneyline in 10 of their last 14 games (+6.30 Units / 9% ROI)
Tulane has hit the Moneyline in 10 of their last 13 games (+6.20 Units / 17% ROI)
Tulane has hit the Game Total Under in 10 of their last 14 games (+5.60 Units / 36% ROI)
Tulane has hit the 1Q Moneyline in 7 of their last 14 games (+3.50 Units / 10% ROI)

Ole Miss Best Bets Today

Ole Miss has hit the Moneyline in 9 of their last 10 games (+8.65 Units / 26% ROI)
Ole Miss has hit the 1H Moneyline in 11 of their last 12 games (+8.45 Units / 7% ROI)
Ole Miss have covered the Spread in 6 of their last 8 games at home (+3.80 Units / 43% ROI)
Ole Miss have covered the 1H Spread in 8 of their last 12 games (+3.20 Units / 23% ROI)
Ole Miss has hit the Team Total Under in 4 of their last 5 games at home (+2.85 Units / 49% ROI)

Tulane Against the Spread (ATS) Record

Tulane is 6-6 against the spread this college football season (-0.6 Units / -4.2% ROI).

Tulane is 10-2 when betting on the Moneyline for +7.2 Units / 19.92% ROI
Tulane is 4-9 when betting the Over for -5.85 Units / -41.05% ROI
Tulane is 9-4 when betting the Under for +4.6 Units / 32.06% ROI

Ole Miss Against the Spread (ATS) Record

Mississippi iss 7-4 against the spread this college football season (+2.6 Units / 21.4% ROI).

Ole Miss is 8-1 when betting on the Moneyline for +7.65 Units / 31.22% ROI
Ole Miss is 6-5 when betting the Over for +0.5 Units / 4.13% ROI
Ole Miss is 5-6 when betting the Under for -1.6 Units / -13.22% ROI

Tulane: Keys to the Game vs. Ole Miss

Ole Miss have averaged 19.6 yards per reception (646 yards/33 catches) in the 4th quarter this season– best among FBS Offenses; Average: 11.6

Ole Miss have averaged 19.6 yards per completion (646 yards/33 completions) in the 4th quarter this season– best among FBS Offenses; Average: 11.6

Ole Miss TEs have averaged 24.2 yards per reception (145 yards/6 catches) in the 4th quarter this season– best among Power Conference Teams; Average: 11.2

Ole Miss Skill Players have averaged 19.6 yards per reception (646 yards/33 catches) in the 4th quarter this season– best among FBS Teams; Average: 11.7

Ole Miss Skill Players have averaged 19.6 yards per reception (646 yards/33 catches) in the 4th quarter this season– best among Power Conference Teams; Average: 11.9

Ole Miss: Keys to the Game vs. Tulane

Tulane was 9-3 (.750) when rushing for more than 100 yards last season– T-14th-best among Non-Power Conference Teams; Average: .572

Tulane is 8-2 (.800) when rushing at least 4 yards in a play 10 or more times this season– T-23rd-best in FBS; Average: .587

Tulane was 8-1 (.889) when not losing a fumble last season– T-2nd-best among Non-Power Conference Teams; Average: .533

Tulane is 6-1 (.857) when converting 55% or more of its red zone chances into touchdowns this season– T-11th-best among Non-Power Conference Teams; Average: .604

Matchup Notes for Tulane vs. Ole Miss