Syracuse vs SMU Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 6

SMU head coach Rhett Lashlee runs out with his team before an NCAA college game against TCU on Saturday, Sept. 24, 2022, in Dallas, Texas. (AP Photo/Gareth Patterson)
(AP Photo/Gareth Patterson)
  • SMU is a -17.5 point favorite vs. Syracuse
  • Syracuse vs. SMU Total (Over/Under): 58.5 points
  • TV Channel: ACCN

Syracuse (3-2) visit Gerald J. Ford Stadium to take on SMU (2-2) on Oct. 4 in Dallas, TX. Kickoff is scheduled for 3:30pm EDT.

SMU is a betting favorite in Week 6, with the spread sitting at -17.5 (-105).

The Syracuse vs. SMU Over/Under is 58.5 total points.

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Syracuse vs. SMU Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Syracuse+17.5 -11558.5 -110550
SMU -17.5 -10558.5 -110-800

Syracuse vs SMU Prediction:

The winning team model predicts SMU will win this game with 80.8% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Syracuse and SMU, key player performances this season and recent team trends.

Syracuse vs SMU Spread Prediction:

Based on recent against-the-spread trends, the model predicts Syracuse will cover the spread with 78.2% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • Syracuse has hit the Moneyline in 9 of their last 13 games (+15.40 Units / 59% ROI)
  • Syracuse has hit the 1H Moneyline in 4 of their last 7 away games (+5.40 Units / 39% ROI)
  • Syracuse has hit the 1H Game Total Over in 6 of their last 8 away games (+4.85 Units / 52% ROI)
  • Syracuse has hit the Game Total Over in 9 of their last 14 games (+4.60 Units / 30% ROI)
  • Syracuse have covered the 1H Spread in 5 of their last 8 away games (+1.60 Units / 18% ROI)
  • SMU has hit the 1H Moneyline in 9 of their last 12 games (+5.90 Units / 11% ROI)
  • SMU has hit the 1Q Game Total Under in 8 of their last 11 games (+4.75 Units / 38% ROI)
  • SMU has hit the Moneyline in 8 of their last 12 games (+4.25 Units / 5% ROI)
  • SMU have covered the 1Q Spread in 4 of their last 5 games at home (+3.00 Units / 54% ROI)
  • SMU has hit the 1Q Moneyline in 4 of their last 5 games at home (+2.65 Units / 22% ROI)

Syracuse Against the Spread (ATS) Record

Syracuse is 2-2 against the spread this college football season (-0.2 Units / -3.64% ROI).

  • Syracuse is 2-2 when betting on the Moneyline for +4.8 Units / 83.48% ROI
  • Syracuse is 3-2 when betting the Over for +0.8 Units / 14.55% ROI
  • Syracuse is 2-3 when betting the Under for -1.3 Units / -23.64% ROI

SMU Against the Spread (ATS) Record

SMU iss 0-4 against the spread this college football season (-4.4 Units / -100% ROI).

  • SMU is 1-2 when betting on the Moneyline for -1.5 Units / -3.53% ROI
  • SMU is 1-3 when betting the Over for -2.3 Units / -52.27% ROI
  • SMU is 3-1 when betting the Under for +1.9 Units / 43.18% ROI

Syracuse: Keys to the Game vs. SMU

Syracuse’s offense has thrown for 20 or more yards on 14.8% of 169 attempts this season — T-18th-best among FBS offenses. SMU’s defense allowed 20+ yards on 13.5% of attempts this season — 3rd-worst among ACC defenses.

Syracuse’s offense has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS offenses. SMU’s defense has allowed 334.5 passing yards per game this season — worst among FBS defenses.

Syracuse’s offense has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS offenses. SMU’s defense has allowed 334.5 passing yards per game this season — worst among P5 defenses.

Syracuse WRs have 6 receptions for 20 or more yards in the 4th quarter this season– T-2nd-most among FBS Teams

Syracuse’s QBs has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS teams. SMU’s defense has allowed 334.5 passing yards per game this season — worst among P5 defenses.

SMU: Keys to the Game vs. Syracuse

Syracuse was 6-3 (.667) when in a one score game last season– T-12th-best among Power Conference Teams; Average: .514

Syracuse is 8-1 (.889) when allowing less than 3 sacks since the 2024 season– T-11th-best among Power Conference Teams; Average: .703

Syracuse is 10-2 (.833) when committing less than 60 yards in penalties since the 2024 season– T-5th-best among Power Conference Teams; Average: .589

Syracuse is 10-2 (.833) when rushing at least 4 yards in a play 10 or more times since the 2024 season– T-13th-best in FBS; Average: .598

Matchup Notes for Syracuse vs. SMU

Syracuse was 6-3 (.667) when in a one score game last season– T-12th-best among Power Conference Teams; Average: .514

Syracuse is 8-1 (.889) when allowing less than 3 sacks since the 2024 season– T-11th-best among Power Conference Teams; Average: .703

Syracuse is 10-2 (.833) when committing less than 60 yards in penalties since the 2024 season– T-5th-best among Power Conference Teams; Average: .589

Syracuse is 10-2 (.833) when rushing at least 4 yards in a play 10 or more times since the 2024 season– T-13th-best in FBS; Average: .598

Syracuse’s offense has thrown for 20 or more yards on 14.8% of 169 attempts this season — T-18th-best among FBS offenses. SMU’s defense allowed 20+ yards on 13.5% of attempts this season — 3rd-worst among ACC defenses.

Syracuse’s offense has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS offenses. SMU’s defense has allowed 334.5 passing yards per game this season — worst among FBS defenses.

Syracuse’s offense has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS offenses. SMU’s defense has allowed 334.5 passing yards per game this season — worst among P5 defenses.

Syracuse WRs have 6 receptions for 20 or more yards in the 4th quarter this season– T-2nd-most among FBS Teams

Syracuse’s QBs has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS teams. SMU’s defense has allowed 334.5 passing yards per game this season — worst among P5 defenses.

Syracuse Offensive Stats & Trends

Syracuse’s offense has thrown for 20 or more yards on 14.8% of 169 attempts this season — T-18th-best among FBS offenses. SMU’s defense allowed 20+ yards on 13.5% of attempts this season — 3rd-worst among ACC defenses.

Syracuse’s offense has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS offenses. SMU’s defense has allowed 334.5 passing yards per game this season — worst among FBS defenses.

Syracuse’s offense has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS offenses. SMU’s defense has allowed 334.5 passing yards per game this season — worst among P5 defenses.

Syracuse WRs have 6 receptions for 20 or more yards in the 4th quarter this season– T-2nd-most among FBS Teams

Syracuse’s QBs has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS teams. SMU’s defense has allowed 334.5 passing yards per game this season — worst among P5 defenses.

SMU Offensive Stats & Trends

Syracuse was 6-3 (.667) when in a one score game last season– T-12th-best among Power Conference Teams; Average: .514

Syracuse is 8-1 (.889) when allowing less than 3 sacks since the 2024 season– T-11th-best among Power Conference Teams; Average: .703

Syracuse is 10-2 (.833) when committing less than 60 yards in penalties since the 2024 season– T-5th-best among Power Conference Teams; Average: .589

Syracuse is 10-2 (.833) when rushing at least 4 yards in a play 10 or more times since the 2024 season– T-13th-best in FBS; Average: .598

Syracuse Defensive Stats & Trends

Syracuse’s offense has thrown for 20 or more yards on 14.8% of 169 attempts this season — T-18th-best among FBS offenses. SMU’s defense allowed 20+ yards on 13.5% of attempts this season — 3rd-worst among ACC defenses.

Syracuse’s offense has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS offenses. SMU’s defense has allowed 334.5 passing yards per game this season — worst among FBS defenses.

Syracuse’s offense has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS offenses. SMU’s defense has allowed 334.5 passing yards per game this season — worst among P5 defenses.

Syracuse WRs have 6 receptions for 20 or more yards in the 4th quarter this season– T-2nd-most among FBS Teams

Syracuse’s QBs has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS teams. SMU’s defense has allowed 334.5 passing yards per game this season — worst among P5 defenses.

SMU Defensive Stats & Trends

Syracuse was 6-3 (.667) when in a one score game last season– T-12th-best among Power Conference Teams; Average: .514

Syracuse is 8-1 (.889) when allowing less than 3 sacks since the 2024 season– T-11th-best among Power Conference Teams; Average: .703

Syracuse is 10-2 (.833) when committing less than 60 yards in penalties since the 2024 season– T-5th-best among Power Conference Teams; Average: .589

Syracuse is 10-2 (.833) when rushing at least 4 yards in a play 10 or more times since the 2024 season– T-13th-best in FBS; Average: .598


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