Syracuse vs Notre Dame Prediction, Odds & Best Prop Bets – NCAAF, Week 13

BetMGM Betting Nov 19, 2025, 12:30 PM

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Notre Dame head coach Marcus Freeman looks at the scoreboard during the first half of the team's NCAA college football game against Stanford in South Bend, Ind., Saturday, Oct. 15, 2022.

(AP Photo/Nam Y. Huh)

Notre Dame is a -35.5 point favorite vs. Syracuse
Syracuse vs. Notre Dame Total (Over/Under): 50.5 points
TV Channel: NBC | PEAC

Syracuse (3-7) visit Notre Dame Stadium to take on Notre Dame (8-2) on Nov. 22 in South Bend, IN. Kickoff is scheduled for 3:30pm EST.

Notre Dame is a betting favorite in Week 13, with the spread sitting at -35.5 (-110).

The Syracuse vs. Notre Dame Over/Under is 50.5 total points.

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Syracuse vs. Notre Dame Odds, Spread, Over/Under:

	Spread	Total (O/U)	Moneyline
Syracuse	+35.5 -110	50.5 -110
Notre Dame	-35.5 -110	50.5 -110

Syracuse vs Notre Dame Prediction:

The winning team model predicts Notre Dame will win this game with 75.2% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Syracuse and Notre Dame, key player performances this season and recent team trends.

Syracuse vs Notre Dame Spread Prediction:

Based on recent against-the-spread trends, the model predicts Syracuse will cover the spread with 54.8% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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Syracuse Best Bets Today

Syracuse has hit the Moneyline in 5 of their last 12 games (+4.95 Units / 20% ROI)
Syracuse has hit the Game Total Over in 5 of their last 6 away games (+3.90 Units / 59% ROI)
Syracuse has hit the Team Total Under in 5 of their last 6 games (+3.70 Units / 52% ROI)
Syracuse have covered the 1Q Spread in 4 of their last 6 away games (+1.75 Units / 26% ROI)
Syracuse has hit the 1Q Game Total Over in 7 of their last 13 games (+1.70 Units / 12% ROI)

Notre Dame Best Bets Today

Notre Dame has hit the Moneyline in 13 of their last 15 games (+9.15 Units / 5% ROI)
Notre Dame has hit the 1Q Moneyline in 10 of their last 13 games (+7.90 Units / 17% ROI)
Notre Dame has hit the 1H Moneyline in 11 of their last 14 games (+6.35 Units / 5% ROI)
Notre Dame have covered the Spread in 10 of their last 15 games (+4.50 Units / 27% ROI)
Notre Dame have covered the 1Q Spread in 8 of their last 15 games (+2.45 Units / 14% ROI)

Syracuse Against the Spread (ATS) Record

Syracuse is 4-5 against the spread this college football season (-1.5 Units / -13.64% ROI).

Syracuse is 2-7 when betting on the Moneyline for -0.4 Units / -3.65% ROI
Syracuse is 5-5 when betting the Over for -0.5 Units / -4.55% ROI
Syracuse is 5-5 when betting the Under for -0.5 Units / -4.55% ROI

Notre Dame Against the Spread (ATS) Record

Notre Dame iss 5-5 against the spread this college football season (-0.5 Units / -4.52% ROI).

Notre Dame is 8-2 when betting on the Moneyline for +4.15 Units / 2.64% ROI
Notre Dame is 5-5 when betting the Over for -0.5 Units / -4.55% ROI
Notre Dame is 5-5 when betting the Under for -0.5 Units / -4.55% ROI

Syracuse: Keys to the Game vs. Notre Dame

Notre Dame have completed passes for 20+ yards on 47 of their 270 total passing attempts (17%) this season– 2nd-best among FBS Offenses; Average: 10%

Notre Dame have averaged 17.9 yards per reception (1,344 yards/75 catches) on 1st down this season– 3rd-best among FBS Offenses; Average: 12.3

Notre Dame Skill Players have averaged 17.9 yards per reception (1,344 yards/75 catches) on 1st down this season– best among Power Conference Teams; Average: 12.5

Notre Dame RBs have averaged 9.9 Yards per Carry (238 yards/24 carries) in close and late situations this season– 3rd-best among FBS Teams; Average: 5.0

Notre Dame RBs have averaged 191.2 rushing yards per game (1,912/10) this season– 4th-best among FBS Teams; Average: 123.8

Notre Dame: Keys to the Game vs. Syracuse

Notre Dame opponents has averaged 9.7 Passing Attempts per TD (29 Pass Attempts/3 Passing TDs) in the Red Zone this season– best in FBS; Average: 3.9

Notre Dame has allowed a Completion Pct of just 31% (9 completions/29 attempts) in the Red Zone this season– best in FBS; Average: 55%

Notre Dame allowed a Completion Pct of just 53% (235 completions/447 attempts) last season– 3rd-best in FBS; Average: 61%

Notre Dame has 17 interceptions this season– 3rd-most in FBS

Notre Dame opponents averaged 46.4 Passing Attempts per TD (371 Pass Attempts/8 Passing TDs) in the 2023 season– 2nd-best in FBS; Average: 20.1

Matchup Notes for Syracuse vs. Notre Dame