Northwestern vs USC Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 11

Southern California head coach Lincoln Riley watches during the first half of an NCAA college football game against Utah, Saturday, Oct. 21, 2023, in Los Angeles. (AP Photo/Ryan Sun)
(AP Photo/Ryan Sun)
  • USC is a -14 point favorite vs. Northwestern
  • Northwestern vs. USC Total (Over/Under): 50.5 points
  • TV Channel: FOX

Northwestern (5-3) visit Los Angeles Memorial Coliseum to take on USC (6-2) on Nov. 7 in Los Angeles, CA. Kickoff is scheduled for 9:00pm EST.

USC is a betting favorite in Week 11, with the spread sitting at -14 (-110).

The Northwestern vs. USC Over/Under is 50.5 total points.

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Northwestern vs. USC Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Northwestern+14 -11050.5 -105450
USC -14 -11050.5 -115-625

Northwestern vs USC Prediction:

The winning team model predicts USC will win this game with 78.5% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Northwestern and USC, key player performances this season and recent team trends.

Northwestern vs USC Spread Prediction:

Based on recent against-the-spread trends, the model predicts Northwestern will cover the spread with 51.6% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • Northwestern has hit the Moneyline in 5 of their last 10 games (+7.50 Units / 12% ROI)
  • Northwestern have covered the 1H Spread in 8 of their last 11 games (+4.50 Units / 35% ROI)
  • Northwestern has hit the 1Q Moneyline in 5 of their last 10 games (+3.90 Units / 15% ROI)
  • Northwestern has hit the Team Total Over in 5 of their last 7 games (+2.75 Units / 34% ROI)
  • Northwestern have covered the Spread in 6 of their last 11 games (+1.60 Units / 13% ROI)
  • USC have covered the 1H Spread in 9 of their last 12 games (+5.40 Units / 38% ROI)
  • USC has hit the Moneyline in 8 of their last 11 games (+4.20 Units / 5% ROI)
  • USC has hit the 1H Game Total Over in 5 of their last 6 games at home (+3.85 Units / 55% ROI)
  • USC has hit the 1Q Moneyline in 4 of their last 5 games at home (+3.00 Units / 9% ROI)
  • USC has hit the Team Total Under in 4 of their last 6 games (+1.85 Units / 27% ROI)

Northwestern Against the Spread (ATS) Record

Northwestern is 5-2 against the spread this college football season (+2.8 Units / 31.82% ROI).

  • Northwestern is 5-3 when betting on the Moneyline for +9.5 Units / 15.25% ROI
  • Northwestern is 3-5 when betting the Over for -2.5 Units / -28.41% ROI
  • Northwestern is 5-3 when betting the Under for +1.7 Units / 19.32% ROI

USC Against the Spread (ATS) Record

USC iss 4-4 against the spread this college football season (-0.4 Units / -4.55% ROI).

  • USC is 5-2 when betting on the Moneyline for +1.65 Units / 2.11% ROI
  • USC is 4-4 when betting the Over for -0.4 Units / -4.55% ROI
  • USC is 4-4 when betting the Under for -0.4 Units / -4.55% ROI

Northwestern: Keys to the Game vs. USC

Northwestern was winless (0-7) when allowing 100 or more rushing yards last season– T-worst in FBS; Average: .422

Northwestern was winless (0-6) when allowing more than 3 explosive runs last season– T-worst in FBS; Average: .414

Northwestern was winless (0-7) when allowing 120 or more rushing yards last season– T-worst in FBS; Average: .379

Northwestern was 1-8 (.111) when the opposing team converts 55% or more of its red zone chances into touchdowns last season– T-5th-worst among Power Conference Teams; Average: .451

USC: Keys to the Game vs. Northwestern

USC did not allow an opponent to rush for 10 or more yards on any of their 12 carries on 3rd and long last season– T-best in the Big Ten; Average: 14%

USC allowed 4.4 touchdowns per interception (31 TDs allowed, and 7 INT) in the 2023 season– 3rd-worst among Power Conference Teams; Average: 1.7

USC allowed 4.4 touchdowns per interception (31 TDs allowed, and 7 INT) in the 2023 season– worst in the Big Ten; Average: 1.6

USC did not allow an opponent to rush for 10 or more yards on any of their 12 carries on 3rd and long last season– T-best among Power Conference Teams; Average: 17%

USC tackled opponents for a loss on just 49 of 403 rushing attempts (12% TFL%) last season– 4th-worst in the Big Ten; Average: 16%.

Matchup Notes for Northwestern vs. USC

USC did not allow an opponent to rush for 10 or more yards on any of their 12 carries on 3rd and long last season– T-best in the Big Ten; Average: 14%

USC allowed 4.4 touchdowns per interception (31 TDs allowed, and 7 INT) in the 2023 season– 3rd-worst among Power Conference Teams; Average: 1.7

USC allowed 4.4 touchdowns per interception (31 TDs allowed, and 7 INT) in the 2023 season– worst in the Big Ten; Average: 1.6

USC did not allow an opponent to rush for 10 or more yards on any of their 12 carries on 3rd and long last season– T-best among Power Conference Teams; Average: 17%

USC tackled opponents for a loss on just 49 of 403 rushing attempts (12% TFL%) last season– 4th-worst in the Big Ten; Average: 16%.

Northwestern was winless (0-7) when allowing 100 or more rushing yards last season– T-worst in FBS; Average: .422

Northwestern was winless (0-6) when allowing more than 3 explosive runs last season– T-worst in FBS; Average: .414

Northwestern was winless (0-7) when allowing 120 or more rushing yards last season– T-worst in FBS; Average: .379

Northwestern was 1-8 (.111) when the opposing team converts 55% or more of its red zone chances into touchdowns last season– T-5th-worst among Power Conference Teams; Average: .451

Northwestern Offensive Stats & Trends

Northwestern was winless (0-7) when allowing 100 or more rushing yards last season– T-worst in FBS; Average: .422

Northwestern was winless (0-6) when allowing more than 3 explosive runs last season– T-worst in FBS; Average: .414

Northwestern was winless (0-7) when allowing 120 or more rushing yards last season– T-worst in FBS; Average: .379

Northwestern was 1-8 (.111) when the opposing team converts 55% or more of its red zone chances into touchdowns last season– T-5th-worst among Power Conference Teams; Average: .451

USC Offensive Stats & Trends

USC did not allow an opponent to rush for 10 or more yards on any of their 12 carries on 3rd and long last season– T-best in the Big Ten; Average: 14%

USC allowed 4.4 touchdowns per interception (31 TDs allowed, and 7 INT) in the 2023 season– 3rd-worst among Power Conference Teams; Average: 1.7

USC allowed 4.4 touchdowns per interception (31 TDs allowed, and 7 INT) in the 2023 season– worst in the Big Ten; Average: 1.6

USC did not allow an opponent to rush for 10 or more yards on any of their 12 carries on 3rd and long last season– T-best among Power Conference Teams; Average: 17%

USC tackled opponents for a loss on just 49 of 403 rushing attempts (12% TFL%) last season– 4th-worst in the Big Ten; Average: 16%.

Northwestern Defensive Stats & Trends

Northwestern was winless (0-7) when allowing 100 or more rushing yards last season– T-worst in FBS; Average: .422

Northwestern was winless (0-6) when allowing more than 3 explosive runs last season– T-worst in FBS; Average: .414

Northwestern was winless (0-7) when allowing 120 or more rushing yards last season– T-worst in FBS; Average: .379

Northwestern was 1-8 (.111) when the opposing team converts 55% or more of its red zone chances into touchdowns last season– T-5th-worst among Power Conference Teams; Average: .451

USC Defensive Stats & Trends

USC did not allow an opponent to rush for 10 or more yards on any of their 12 carries on 3rd and long last season– T-best in the Big Ten; Average: 14%

USC allowed 4.4 touchdowns per interception (31 TDs allowed, and 7 INT) in the 2023 season– 3rd-worst among Power Conference Teams; Average: 1.7

USC allowed 4.4 touchdowns per interception (31 TDs allowed, and 7 INT) in the 2023 season– worst in the Big Ten; Average: 1.6

USC did not allow an opponent to rush for 10 or more yards on any of their 12 carries on 3rd and long last season– T-best among Power Conference Teams; Average: 17%

USC tackled opponents for a loss on just 49 of 403 rushing attempts (12% TFL%) last season– 4th-worst in the Big Ten; Average: 16%.


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