Michigan St vs Iowa Prediction, Odds & Best Prop Bets – NCAAF, Week 13

BetMGM Betting Nov 19, 2025, 12:32 PM

min read

Fans cheer before an NCAA college football game between Iowa and North Texas at Kinnick Stadium in Iowa City, Iowa, Sept. 16, 2017. Iowa will attempt to set the all-time women's basketball attendance record when it hosts DePaul in an outdoor exhibition at 69,000-seat Kinnick Stadium on Oct. 15, the school announced Thursday, Aug. 10, 2023.

(AP Photo/Charlie Neibergall)

Iowa is a -16.5 point favorite vs. Michigan St
Michigan State vs. Iowa Total (Over/Under): 42.5 points
TV Channel: FS1

Michigan State (3-7) visit Kinnick Stadium to take on Iowa (6-4) on Nov. 22 in Iowa City, IA. Kickoff is scheduled for 3:30pm EST.

Iowa is a betting favorite in Week 13, with the spread sitting at -16.5 (-118).

The Michigan State vs. Iowa Over/Under is 42.5 total points.

Bet now on Iowa vs Michigan St & all NCAAF games with BetMGM

Michigan State vs. Iowa Odds, Spread, Over/Under:

	Spread	Total (O/U)	Moneyline
Michigan State	+16.5 -102	42.5 -110	575
Iowa	-16.5 -118	42.5 -110	-900

Michigan State vs Iowa Prediction:

The winning team model predicts Iowa will win this game with 77.5% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Michigan St and Iowa, key player performances this season and recent team trends.

Michigan State vs Iowa Spread Prediction:

Based on recent against-the-spread trends, the model predicts Michigan State will cover the spread with 52.3% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

Bet now on Iowa vs Michigan St and all games with BetMGM

Get a New Customer Offer

Michigan State Best Bets Today

Michigan State has hit the Team Total Over in 6 of their last 9 games (+2.45 Units / 24% ROI)
Michigan State has hit the Game Total Over in 7 of their last 12 games (+1.50 Units / 11% ROI)

Iowa Best Bets Today

Iowa have covered the Spread in 8 of their last 13 games (+4.74 Units / 33% ROI)
Iowa has hit the Team Total Over in 6 of their last 8 games (+3.75 Units / 40% ROI)
Iowa has hit the 1H Game Total Over in 8 of their last 13 games (+2.25 Units / 15% ROI)
Iowa has hit the 1H Moneyline in 6 of their last 12 games (+1.55 Units / 3% ROI)
Iowa have covered the 1H Spread in 7 of their last 12 games (+1.50 Units / 11% ROI)

Michigan State Against the Spread (ATS) Record

Michigan St is 5-5 against the spread this college football season (-0.45 Units / -4.11% ROI).

Michigan State is 3-7 when betting on the Moneyline for -5.7 Units / -12.3% ROI
Michigan State is 6-4 when betting the Over for +1.6 Units / 14.55% ROI
Michigan State is 4-6 when betting the Under for -2.6 Units / -23.64% ROI

Iowa Against the Spread (ATS) Record

Iowa iss 7-2 against the spread this college football season (+4.84 Units / 44.36% ROI).

Iowa is 4-4 when betting on the Moneyline for +0 Units / 0% ROI
Iowa is 4-6 when betting the Over for -2.6 Units / -23.64% ROI
Iowa is 6-4 when betting the Under for +1.6 Units / 14.51% ROI

Michigan State: Keys to the Game vs. Iowa

Michigan State WRs averaged just 4.0 yards per reception (20 yards/5 catches) last week– worst among Big Ten Teams; Average: 12.0

Michigan State WRs averaged just 4.0 yards per reception (20 yards/5 catches) last week– worst among Power Conference Teams; Average: 13.2

Michigan State TEs had just one touchdown on 50 receptions last season– 4th-worst Receptions Per TD among Power Conference Teams; Average: 10.3

Michigan State Skill Players have averaged 14.1 yards per reception (665 yards/47 catches) in the 4th quarter this season– 2nd-best among Big Ten Teams; Average: 11.4

Michigan State have been sacked on 20% of pass attempts (16/78) in the 4th quarter this season– worst among Big Ten Offenses; Average: 7%

Iowa: Keys to the Game vs. Michigan State

Iowa was 8-2 (.800) when allowing less than 5 yards per rush last season– T-15th-best among Power Conference Teams; Average: .647

Iowa was 8-2 (.800) when allowing less than 5 yards per rush last season– T-26th-best in FBS; Average: .632

Iowa was 2-5 (.286) when having a turnover margin within one of the opposing team last season– T-4th-worst among Power Conference Teams; Average: .578

Iowa was undefeated (7-0) when having a turnover margin within one of the opposing team in the 2023 season– T-best among Power Conference Teams; Average: .582

Matchup Notes for Michigan State vs. Iowa