Louisville vs SMU Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 13

SMU head coach Rhett Lashlee runs out with his team before an NCAA college game against TCU on Saturday, Sept. 24, 2022, in Dallas, Texas. (AP Photo/Gareth Patterson)
(AP Photo/Gareth Patterson)
  • SMU is a -2.5 point favorite vs. Louisville
  • Louisville vs. SMU Total (Over/Under): 52.5 points
  • TV Channel: ESPN2

Louisville (7-3) visit Gerald J. Ford Stadium to take on SMU (7-3) on Nov. 22 in Dallas, TX. Kickoff is scheduled for 12:00pm EST.

SMU is a betting favorite in Week 13, with the spread sitting at -2.5 (-115).

The Louisville vs. SMU Over/Under is 52.5 total points.

Bet now on SMU vs Louisville & all NCAAF games with BetMGM

Louisville vs. SMU Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Louisville+2.5 -10552.5 -105125
SMU -2.5 -11552.5 -115-150

Louisville vs SMU Prediction:

The winning team model predicts SMU will win this game with 58.6% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Louisville and SMU, key player performances this season and recent team trends.

Louisville vs SMU Spread Prediction:

Based on recent against-the-spread trends, the model predicts Louisville will cover the spread with 51.6% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


Bet now on SMU vs Louisville and all games with BetMGM


  • Louisville has hit the Moneyline in their last 5 away games (+7.40 Units / 80% ROI)
  • Louisville have covered the Spread in their last 5 away games (+5.00 Units / 91% ROI)
  • Louisville has hit the Team Total Under in 5 of their last 6 games (+3.90 Units / 59% ROI)
  • Louisville has hit the 1Q Game Total Over in 4 of their last 5 away games (+3.00 Units / 56% ROI)
  • Louisville has hit the 1H Game Total Under in 8 of their last 13 games (+2.10 Units / 14% ROI)
  • SMU has hit the 1Q Game Total Under in 11 of their last 13 games (+9.10 Units / 59% ROI)
  • SMU has hit the 1H Game Total Under in 11 of their last 14 games (+7.60 Units / 47% ROI)
  • SMU has hit the Game Total Under in 10 of their last 14 games (+5.60 Units / 36% ROI)
  • SMU has hit the Moneyline in 8 of their last 13 games (+3.20 Units / 4% ROI)
  • SMU has hit the 1H Moneyline in 8 of their last 13 games (+1.95 Units / 4% ROI)

Louisville Against the Spread (ATS) Record

Louisville is 3-7 against the spread this college football season (-4.7 Units / -42.73% ROI).

  • Louisville is 7-3 when betting on the Moneyline for -4.2 Units / -3.47% ROI
  • Louisville is 5-5 when betting the Over for -0.5 Units / -4.55% ROI
  • Louisville is 5-5 when betting the Under for -0.5 Units / -4.55% ROI

SMU Against the Spread (ATS) Record

SMU iss 4-6 against the spread this college football season (-2.6 Units / -23.64% ROI).

  • SMU is 6-3 when betting on the Moneyline for +3.55 Units / 5.17% ROI
  • SMU is 3-7 when betting the Over for -4.7 Units / -42.73% ROI
  • SMU is 7-3 when betting the Under for +3.7 Units / 33.64% ROI

Louisville: Keys to the Game vs. SMU

Louisville has allowed passes of 40+ yards on just 2 of 317 attempts (1%) this season– T-best in FBS; Average: 2%

Louisville has allowed passes of 40+ yards on just 2 of 317 attempts (1%) this season– T-best among Power Conference Teams; Average: 2%

Louisville has allowed a Completion Pct of 89% (8 completions/9 attempts) on 3rd and short this season– T-7th-worst in FBS; Average: 64%

Louisville tackled opponents for a loss on 82 of 464 rushing attempts (18% TFL%) last season– T-35th-best in FBS; Average: 16%.

Louisville has tackled opponents for a loss on just 4 of 50 rushing attempts (8% TFL%) in the Red Zone this season– T-18th-worst in FBS; Average: 14%.

SMU: Keys to the Game vs. Louisville

Louisville was 9-3 (.750) when allowing less than 50% of third down conversion opportunities last season– T-31st-best in FBS; Average: .602

Louisville was 8-4 (.667) when their opponent rushed more than 30 times last season– T-24th-best in FBS; Average: .442

Louisville was 6-2 (.750) when sacking the QB less than 3 times last season– T-12th-best in FBS; Average: .429

Louisville was 5-1 (.833) when intercepting at least 1 pass last season– T-24th-best in FBS; Average: .668

Matchup Notes for Louisville vs. SMU

Louisville was 9-3 (.750) when allowing less than 50% of third down conversion opportunities last season– T-31st-best in FBS; Average: .602

Louisville was 8-4 (.667) when their opponent rushed more than 30 times last season– T-24th-best in FBS; Average: .442

Louisville was 6-2 (.750) when sacking the QB less than 3 times last season– T-12th-best in FBS; Average: .429

Louisville was 5-1 (.833) when intercepting at least 1 pass last season– T-24th-best in FBS; Average: .668

Louisville has allowed passes of 40+ yards on just 2 of 317 attempts (1%) this season– T-best in FBS; Average: 2%

Louisville has allowed passes of 40+ yards on just 2 of 317 attempts (1%) this season– T-best among Power Conference Teams; Average: 2%

Louisville has allowed a Completion Pct of 89% (8 completions/9 attempts) on 3rd and short this season– T-7th-worst in FBS; Average: 64%

Louisville tackled opponents for a loss on 82 of 464 rushing attempts (18% TFL%) last season– T-35th-best in FBS; Average: 16%.

Louisville has tackled opponents for a loss on just 4 of 50 rushing attempts (8% TFL%) in the Red Zone this season– T-18th-worst in FBS; Average: 14%.

Louisville Offensive Stats & Trends

Louisville has allowed passes of 40+ yards on just 2 of 317 attempts (1%) this season– T-best in FBS; Average: 2%

Louisville has allowed passes of 40+ yards on just 2 of 317 attempts (1%) this season– T-best among Power Conference Teams; Average: 2%

Louisville has allowed a Completion Pct of 89% (8 completions/9 attempts) on 3rd and short this season– T-7th-worst in FBS; Average: 64%

Louisville tackled opponents for a loss on 82 of 464 rushing attempts (18% TFL%) last season– T-35th-best in FBS; Average: 16%.

Louisville has tackled opponents for a loss on just 4 of 50 rushing attempts (8% TFL%) in the Red Zone this season– T-18th-worst in FBS; Average: 14%.

SMU Offensive Stats & Trends

Louisville was 9-3 (.750) when allowing less than 50% of third down conversion opportunities last season– T-31st-best in FBS; Average: .602

Louisville was 8-4 (.667) when their opponent rushed more than 30 times last season– T-24th-best in FBS; Average: .442

Louisville was 6-2 (.750) when sacking the QB less than 3 times last season– T-12th-best in FBS; Average: .429

Louisville was 5-1 (.833) when intercepting at least 1 pass last season– T-24th-best in FBS; Average: .668

Louisville Defensive Stats & Trends

Louisville has allowed passes of 40+ yards on just 2 of 317 attempts (1%) this season– T-best in FBS; Average: 2%

Louisville has allowed passes of 40+ yards on just 2 of 317 attempts (1%) this season– T-best among Power Conference Teams; Average: 2%

Louisville has allowed a Completion Pct of 89% (8 completions/9 attempts) on 3rd and short this season– T-7th-worst in FBS; Average: 64%

Louisville tackled opponents for a loss on 82 of 464 rushing attempts (18% TFL%) last season– T-35th-best in FBS; Average: 16%.

Louisville has tackled opponents for a loss on just 4 of 50 rushing attempts (8% TFL%) in the Red Zone this season– T-18th-worst in FBS; Average: 14%.

SMU Defensive Stats & Trends

Louisville was 9-3 (.750) when allowing less than 50% of third down conversion opportunities last season– T-31st-best in FBS; Average: .602

Louisville was 8-4 (.667) when their opponent rushed more than 30 times last season– T-24th-best in FBS; Average: .442

Louisville was 6-2 (.750) when sacking the QB less than 3 times last season– T-12th-best in FBS; Average: .429

Louisville was 5-1 (.833) when intercepting at least 1 pass last season– T-24th-best in FBS; Average: .668


Bet now on SMU vs Louisville and all games with BetMGM


More College Football Betting at BetMGM

BetMGM is the best online sportsbook for college football betting.

Whether youโ€™re a first-time bettor checking out the best sportsbook promos, a casual fan betting on Georgia football national championship odds, Michigan football odds, or Ohio State playoff odds, or a longtime diehard breaking down trends for live sports betting, there are entertainment options for everyone.

Visit the sportsbook today to place a college football bet online!

The content provided in this blog is intended for entertainment purposes only. All views and opinions expressed are the authors and reflect their individual perspectives on sports, betting, and related topics. This content should not be considered professional betting advice or the official views of BetMGM LLC. Please gamble responsibly. If you or someone you know is experiencing issues related to gambling, seek help from a licensed health professional. This blog is not liable for any losses, damages, or consequences resulting from betting activities.

About the Author Read More @BETMGM

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.