James Madison vs Oregon Prediction, Odds & Best Prop Bets – College Football Playoffs

BetMGM Betting Dec 19, 2025, 5:19 PM

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FILE - Oregon coach Dan Lanning reacts to a play against BYU during the first half of an NCAA college football game Sept. 17, 2022, in Eugene, Ore. Oregon and head coach Dan Lanning have agreed to a contract extension that will extend his deal through the 2028 season. The Oregon Board of Trustees unanimously approved the terms of the contract Thursday, July 27, 2023. Lanning’s new deal will pay him a total of $45 million in base salary over six years. (AP Photo/Andy Nelson, File)

(AP Photo/Andy Nelson)

Oregon is a -21.5 point favorite vs. James Madison
James Madison vs. Oregon Total (Over/Under): 50.5 points
TV Channel: ABC | ESPN

James Madison (12-1) visit Autzen Stadium to take on Oregon (11-1) on Dec. 20 in Eugene, OR. Kickoff is scheduled for 7:30pm EST.

Oregon is a betting favorite in the College Football Playoffs, with the spread sitting at -21.5 (-110).

The James Madison vs. Oregon Over/Under is 50.5 total points.

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James Madison vs. Oregon Odds, Spread, Over/Under:

	Spread	Total (O/U)	Moneyline
James Madison	+21.5 -110	50.5 -110	950
Oregon	-21.5 -110	50.5 -110	-2000

James Madison vs Oregon Prediction:

The winning team model predicts Oregon will win this game with 76.3% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both James Madison and Oregon, key player performances this season and recent team trends.

James Madison vs Oregon Spread Prediction:

Based on recent against-the-spread trends, the model predicts James Madison will cover the spread with 52.0% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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James Madison Best Bets Today

James Madison has hit the Moneyline in 13 of their last 14 games (+12.00 Units / 8% ROI)
James Madison has hit the 1Q Game Total Under in 10 of their last 14 games (+5.70 Units / 36% ROI)
James Madison has hit the 1Q Moneyline in 9 of their last 14 games (+5.30 Units / 11% ROI)
James Madison have covered the Spread in 9 of their last 14 games (+3.50 Units / 23% ROI)
James Madison has hit the Team Total Over in 4 of their last 5 away games (+2.85 Units / 51% ROI)

Oregon Best Bets Today

Oregon has hit the Moneyline in 11 of their last 13 games (+8.00 Units / 3% ROI)
Oregon has hit the 1H Moneyline in 10 of their last 13 games (+6.65 Units / 2% ROI)
Oregon has hit the 1Q Game Total Over in 7 of their last 8 games at home (+6.15 Units / 64% ROI)
Oregon has hit the 1Q Moneyline in 8 of their last 13 games (+5.05 Units / 8% ROI)
Oregon have covered the 1Q Spread in 9 of their last 13 games (+4.40 Units / 28% ROI)

James Madison Against the Spread (ATS) Record

James Madison is 8-5 against the spread this college football season (+2.5 Units / 17.48% ROI).

James Madison is 12-1 when betting on the Moneyline for +11 Units / 7.03% ROI
James Madison is 5-7 when betting the Over for -2.7 Units / -18.88% ROI
James Madison is 7-5 when betting the Under for +1.5 Units / 10.49% ROI

Oregon Against the Spread (ATS) Record

Oregon iss 8-4 against the spread this college football season (+3.6 Units / 27.27% ROI).

Oregon is 11-1 when betting on the Moneyline for +9 Units / 3.56% ROI
Oregon is 6-6 when betting the Over for -0.6 Units / -4.55% ROI
Oregon is 6-6 when betting the Under for -0.6 Units / -4.55% ROI

James Madison: Keys to the Game vs. Oregon

Oregon has allowed opponents to catch just 126 of 244 passes (52% Reception Pct) this season– best in the Big Ten; Average: 64%

Oregon has allowed a Completion Pct of just 51% (126 completions/248 attempts) this season– best in the Big Ten; Average: 63%

Oregon has allowed a Completion Pct of just 51% (126 completions/248 attempts) this season– 4th-best in FBS; Average: 62%

Oregon allowed a Completion Pct of just 30% (3 completions/10 attempts) on 3rd and short last season– best in the Big Ten; Average: 59%

Oregon has allowed a Completion Pct of just 51% (126 completions/248 attempts) this season– 2nd-best among Power Conference Teams; Average: 62%

Oregon: Keys to the Game vs. James Madison

James Madison has allowed 4 rushing TDs on 313 carries (78.2 Carries Per TD) this season– 2nd-best among Non-Power Conference Teams; Average: 22.2

James Madison has allowed 4 rushing TDs on 313 carries (78.2 Carries Per TD) this season– 4th-best in FBS; Average: 24.1

James Madison has allowed a Completion Pct of just 51% (142 completions/281 attempts) this season– 2nd-best among Non-Power Conference Teams; Average: 62%

James Madison has allowed rushes of 10 or more yards on just 22 of 313 carries (7%) this season– 3rd-best among Non-Power Conference Teams; Average: 13%

James Madison has allowed 3 rushing TDs on 32 carries (10.7 Carries Per TD) in the Red Zone this season– 2nd-best among Non-Power Conference Teams; Average: 4.5

Matchup Notes for James Madison vs. Oregon