Indiana vs Purdue Prediction, Odds & Best Prop Bets – NCAAF, Week 14

BetMGM Betting Nov 28, 2025, 10:32 AM

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(AP Photo/Doug McSchooler)

Indiana is a -28.5 point favorite vs. Purdue
Indiana vs. Purdue Total (Over/Under): 54.5 points
TV Channel: NBC | PEAC

Indiana (11-0) visit Ross-Ade Stadium to take on Purdue (2-9) on Nov. 28 in West Lafayette, IN. Kickoff is scheduled for 7:30pm EST.

Indiana is a betting favorite in Week 14, with the spread sitting at -28.5 (-115).

The Indiana vs. Purdue Over/Under is 54.5 total points.

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Indiana vs. Purdue Odds, Spread, Over/Under:

	Spread	Total (O/U)	Moneyline
Indiana	-28.5 -115	54.5 -115	-10000
Purdue	+28.5 -105	54.5 -105	1800

Indiana vs Purdue Prediction:

The winning team model predicts Indiana will win this game with 73.4% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Indiana and Purdue, key player performances this season and recent team trends.

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Indiana Best Bets Today

Purdue has hit the 1Q Moneyline in 4 of their last 6 games at home (+6.90 Units / 61% ROI)
Purdue has hit the 1Q Game Total Under in 9 of their last 12 games (+5.67 Units / 41% ROI)
Purdue have covered the 1Q Spread in 5 of their last 6 games at home (+3.96 Units / 55% ROI)
Purdue has hit the Game Total Under in 5 of their last 6 games at home (+3.90 Units / 59% ROI)
Purdue has hit the Team Total Under in 7 of their last 11 games (+2.60 Units / 21% ROI)

Purdue Best Bets Today

Indiana has hit the 1Q Moneyline in 11 of their last 13 games (+10.50 Units / 10% ROI)
Indiana has hit the Moneyline in 10 of their last 11 games (+10.20 Units / 5% ROI)
Indiana has hit the 1H Moneyline in 10 of their last 12 games (+9.80 Units / 1% ROI)
Indiana has hit the 1H Game Total Under in their last 5 away games (+5.00 Units / 89% ROI)
Indiana has hit the Team Total Over in 7 of their last 10 games (+3.60 Units / 31% ROI)

Indiana Against the Spread (ATS) Record

Indiana is 6-5 against the spread this college football season (+0.5 Units / 4.13% ROI).

Indiana is 10-0 when betting on the Moneyline for +11.2 Units / 5.15% ROI
Indiana is 6-4 when betting the Over for +1.55 Units / 12.76% ROI
Indiana is 4-6 when betting the Under for -2.6 Units / -21.58% ROI

Purdue Against the Spread (ATS) Record

Purdue iss 5-6 against the spread this college football season (-1.7 Units / -13.93% ROI).

Purdue is 2-9 when betting on the Moneyline for -7.35 Units / -26.87% ROI
Purdue is 3-8 when betting the Over for -5.8 Units / -47.93% ROI
Purdue is 8-3 when betting the Under for +4.7 Units / 38.84% ROI

Indiana: Keys to the Game vs. Purdue

Indiana has tackled opponents for a loss on 80 of 296 rushing attempts (27% TFL%) this season– best in the Big Ten; Average: 16%.

Indiana has tackled opponents for a loss on 80 of 296 rushing attempts (27% TFL%) this season– 2nd-best in FBS; Average: 15%.

Indiana has tackled opponents for a loss on 80 of 296 rushing attempts (27% TFL%) this season– 2nd-best among Power Conference Teams; Average: 16%.

Indiana has allowed opponents to catch just 6 of 17 passes (35% Reception Pct) in the Red Zone this season– best in the Big Ten; Average: 59%

Indiana has allowed a Completion Pct of just 35% (6 completions/17 attempts) in the Red Zone this season– best in the Big Ten; Average: 58%

Purdue: Keys to the Game vs. Indiana

Indiana TEs had no receptions on 2 targets on 3rd down last season– worst among Big Ten Teams; Average: 57%

Indiana WRs have caught 20 touchdown passes in the Red Zone this season– most among Power Conference Teams

Indiana Skill Players have caught 22 touchdown passes in the Red Zone this season– most among Big Ten Teams

Indiana WRs have caught 20 touchdown passes in the Red Zone this season– most among Big Ten Teams

Indiana’s offense has thrown for 20 or more yards on 14.6% of 301 attempts this season — T-7th-best among FBS offenses. Purdue’s defense allowed 20+ yards on 15.0% of attempts this season — T-3rd-worst among FBS defenses.

Matchup Notes for Indiana vs. Purdue