Indiana vs Ohio St Prediction, Odds & Best Prop Bets – Big Ten Championship

BetMGM Betting Dec 05, 2025, 10:39 AM

min read

Ohio State head coach Ryan Day observes Rutgers during warm up before a NCAA college football game, Saturday, Nov. 3, 2023, in Piscataway, N.J. (AP Photo/Noah K. Murray)

(AP Photo/Noah K. Murray)

Ohio St is a -4.5 point favorite vs. Indiana
Indiana vs. Ohio State Total (Over/Under): 47.5 points
TV Channel: FOX

Indiana (12-0) visit Lucas Oil Stadium to take on Ohio State (12-0) on Dec. 6. Kickoff is scheduled for 8:00pm EST.

Ohio St is a betting favorite in the Big Ten Championship, with the spread sitting at -4.5 (-110).

The Indiana vs. Ohio State Over/Under is 47.5 total points.

Bet now on Ohio St vs Indiana & all NCAAF games with BetMGM

Indiana vs. Ohio State Odds, Spread, Over/Under:

	Spread	Total (O/U)	Moneyline
Indiana	+4.5 -110	47.5 -105	165
Ohio State	-4.5 -110	47.5 -115	-200

Indiana vs Ohio State Prediction:

The winning team model predicts Ohio State will win this game with 78.2% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Indiana and Ohio St, key player performances this season and recent team trends.

Indiana vs Ohio State Spread Prediction:

Based on recent against-the-spread trends, the model predicts Ohio State will cover the spread with 64.6% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

Bet now on Ohio St vs Indiana and all games with BetMGM

Get a New Customer Offer

Indiana Best Bets Today

Ohio State has hit the Moneyline in their last 14 games (+14.00 Units / 5% ROI)
Ohio State has hit the 1H Moneyline in their last 14 games (+14.00 Units / 5% ROI)
Ohio State have covered the Spread in 13 of their last 15 games (+10.80 Units / 65% ROI)
Ohio State has hit the 1Q Moneyline in 7 of their last 8 games at home (+7.00 Units / 5% ROI)
Ohio State have covered the 1H Spread in 11 of their last 15 games (+6.45 Units / 37% ROI)

Ohio State Best Bets Today

Indiana has hit the Moneyline in 11 of their last 12 games (+11.20 Units / 4% ROI)
Indiana has hit the 1Q Moneyline in 11 of their last 13 games (+10.50 Units / 10% ROI)
Indiana has hit the 1H Moneyline in 10 of their last 12 games (+9.80 Units / 1% ROI)
Indiana has hit the Team Total Over in 8 of their last 11 games (+4.60 Units / 36% ROI)
Indiana has hit the 1H Game Total Under in 5 of their last 6 away games (+3.85 Units / 57% ROI)

Indiana Against the Spread (ATS) Record

Indiana is 7-5 against the spread this college football season (+1.5 Units / 11.36% ROI).

Indiana is 11-0 when betting on the Moneyline for +12.2 Units / 4.56% ROI
Indiana is 7-4 when betting the Over for +2.55 Units / 19.25% ROI
Indiana is 4-7 when betting the Under for -3.7 Units / -28.14% ROI

Ohio State Against the Spread (ATS) Record

Ohio St iss 10-2 against the spread this college football season (+7.8 Units / 59.09% ROI).

Ohio State is 11-0 when betting on the Moneyline for +11 Units / 4.01% ROI
Ohio State is 4-8 when betting the Over for -4.8 Units / -36.36% ROI
Ohio State is 8-4 when betting the Under for +3.6 Units / 27.27% ROI

Indiana: Keys to the Game vs. Ohio State

Indiana has tackled opponents for a loss on 80 of 296 rushing attempts (27% TFL%) this season– 2nd-best in FBS; Average: 15%.

Indiana has tackled opponents for a loss on 80 of 296 rushing attempts (27% TFL%) this season– best in the Big Ten; Average: 16%.

Indiana has tackled opponents for a loss on 80 of 296 rushing attempts (27% TFL%) this season– 2nd-best among Power Conference Teams; Average: 16%.

Indiana opponents has averaged 50.8 Passing Attempts per TD (305 Pass Attempts/6 Passing TDs) this season– 2nd-best in FBS; Average: 21.5

Indiana has allowed opponents to catch just 6 of 17 passes (35% Reception Pct) in the Red Zone this season– best in the Big Ten; Average: 59%

Ohio State: Keys to the Game vs. Indiana

Ohio State is undefeated (9-0) when allowing less than 5 yards per rush this season– T-best among Power Conference Teams; Average: .659

Ohio State is undefeated (6-0) when averaging more than 5 yards on first down plays this season– T-best among Power Conference Teams; Average: .661

Ohio State is undefeated (5-0) when the opposing team rushes more than 30 times this season– T-best among Power Conference Teams; Average: .486

Ohio State is undefeated (5-0) when the opposing team rushes more than 30 times this season– T-best in FBS; Average: .449

Matchup Notes for Indiana vs. Ohio State