Illinois vs Indiana Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 4

Indiana head coach Curt Cignetti watches from the sideline as his team plays Michigan during the first half of an NCAA college football game in Bloomington, Ind., Saturday, Nov. 9, 2024.
(AP Photo/AJ Mast)
  • Indiana is a -6 point favorite vs. Illinois
  • Illinois vs. Indiana Total (Over/Under): 52.5 points
  • TV Channel: NBC | PEAC

Illinois (3-0) visit Memorial Stadium (Bloomington, IN) to take on Indiana (3-0) on Sep. 20 in Bloomington, IN. Kickoff is scheduled for 7:30pm EDT.

Indiana is a betting favorite in Week 4, with the spread sitting at -6 (-110).

The Illinois vs. Indiana Over/Under is 52.5 total points.

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Illinois vs. Indiana Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Illinois+6 -11052.5 -110180
Indiana -6 -11052.5 -110-220

Illinois vs Indiana Prediction:

The winning team model predicts Indiana will win this game with 77.5% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Illinois and Indiana, key player performances this season and recent team trends.

Illinois vs Indiana Spread Prediction:

Based on recent against-the-spread trends, the model predicts Indiana will cover the spread with 65.0% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • team high – away
  • team high – home

Illinois Against the Spread (ATS) Record

Illinois is 3-0 against the spread this college football season (+3 Units / 90.91% ROI).

  • Illinois is 2-0 when betting on the Moneyline for +2 Units / 4.32% ROI
  • Illinois is 1-2 when betting the Over for -1.2 Units / -36.36% ROI
  • Illinois is 2-1 when betting the Under for +0.9 Units / 27.27% ROI

Indiana Against the Spread (ATS) Record

Indiana iss 2-1 against the spread this college football season (+0.9 Units / 27.27% ROI).

  • Indiana is 2-0 when betting on the Moneyline for +2 Units / 2.78% ROI
  • Indiana is 2-1 when betting the Over for +0.9 Units / 27.27% ROI
  • Indiana is 1-2 when betting the Under for -1.2 Units / -36.36% ROI

Illinois: Keys to the Game vs. Indiana

Illinois was 6-1 (.857) when intercepting at least 1 pass last season– T-21st-best in FBS; Average: .668

Illinois was 7-3 (.700) when their opponent rushed more than 30 times last season– T-20th-best in FBS; Average: .442

Illinois was 6-1 (.857) when in a one score game last season– 3rd-best among Power Conference Teams; Average: .514

Illinois is 9-1 (.900) when not losing a fumble since the 2024 season– T-10th-best among Power Conference Teams; Average: .684

Indiana: Keys to the Game vs. Illinois

Indiana was undefeated (10-0) when averaging more than 5 yards on first down plays last season– T-best in FBS; Average: .604

Indiana was undefeated (10-0) when averaging more than 5 yards on first down plays last season– T-best among Power Conference Teams; Average: .632

Indiana was winless (0-7) when their opponent committed less than 60 yards in penalties in the 2023 season– worst among Power Conference Teams; Average: .576

Indiana is 8-1 (.889) when the opposing team rushes more than 30 times since the 2024 season– 2nd-best in FBS; Average: .455

Matchup Notes for Illinois vs. Indiana

Indiana’s offense has thrown for 20 or more yards on 13.6% of 449 attempts since the 2024 season — 10th-best among FBS offenses. Illinois’s defense allowed 20+ yards on just 7.6% of attempts since the 2024 season — T-11th-best among FBS defenses.

Indiana has gained 4,249 yards on 311 receptions (13.7 YPR) since the 2024 season — best among Big Ten skill players. Illinois’s defense has allowed 11.8 Yards Per Reception to TEs since the 2024 season — T-33rd-worst among FBS defenses.

Indiana has gained 4,249 yards on 311 receptions (13.7 YPR) since the 2024 season — 4th-best among Power 5 skill players. Illinois’s defense has allowed 11.2 Yards Per Reception since the 2024 season — 5th-worst among Big Ten defenses.

Illinois’s offense has thrown for 20 or more yards on 13.9% of 79 attempts this season — T-27th-best among FBS offenses. Indiana’s defense allowed 20+ yards on just 6.3% of attempts this season — T-29th-best among FBS defenses.

Illinois’s TEs has gained 21 yards on 4 receptions (just 5.2 YPR) this season — T-2nd-worst among P5 TEs. Indiana’s defense has allowed just 9.0 Yards Per Reception this season — T-15th-best among FBS defenses.

Illinois’s WRs has gained 3,015 yards on 206 receptions (14.6 YPR) since the 2024 season — T-24th-best among FBS WRs. Indiana’s defense has allowed just 9.2 Yards Per Reception since the 2024 season — best among Big Ten defenses.

Illinois Offensive Stats & Trends

Illinois’s offense has thrown for 20 or more yards on 13.9% of 79 attempts this season — T-27th-best among FBS offenses. Indiana’s defense allowed 20+ yards on just 6.3% of attempts this season — T-29th-best among FBS defenses.

Illinois’s TEs has gained 21 yards on 4 receptions (just 5.2 YPR) this season — T-2nd-worst among P5 TEs. Indiana’s defense has allowed just 9.0 Yards Per Reception this season — T-15th-best among FBS defenses.

Illinois’s WRs has gained 3,015 yards on 206 receptions (14.6 YPR) since the 2024 season — T-24th-best among FBS WRs. Indiana’s defense has allowed just 9.2 Yards Per Reception since the 2024 season — best among Big Ten defenses.

Illinois’s WRs has gained 3,015 yards on 206 receptions (14.6 YPR) since the 2024 season — T-24th-best among FBS WRs. Indiana’s defense has allowed just 9.2 Yards Per Reception since the 2024 season — best among P5 defenses.

Illinois has gained 3,460 yards on 268 receptions (12.9 YPR) since the 2024 season — 3rd-best among Big Ten skill players. Indiana’s defense has allowed just 8.1 Yards Per Reception to TEs since the 2024 season — 8th-best among FBS defenses.

Indiana Offensive Stats & Trends

Indiana threw for 5 TDs in the Red Zone last week– most among FBS Offenses

Indiana WRs have caught 8 touchdown passes in the Red Zone this season– most among FBS Teams

Indiana have thrown for 4 TDs in the 3rd quarter this season– T-most among FBS Offenses

Indiana Skill Players caught 5 touchdown passes in the Red Zone last week– most among Power Conference Teams

Indiana Skill Players caught 5 touchdown passes in the Red Zone last week– most among FBS Teams

Illinois Defensive Stats & Trends

Illinois has not allowed any rushing touchdowns on 84 rushes this season– T-best in FBS; Average: 26.2

Illinois tackled opponents for a loss on just 1 of 36 rushing attempts (3% TFL%) on 3rd and short last season– 2nd-worst among Power Conference Teams; Average: 10%.

Illinois tackled opponents for a loss on just 3 of 67 rushing attempts (4% TFL%) in the Red Zone last season– worst in FBS; Average: 15%.

Illinois tackled opponents for a loss on just 3 of 67 rushing attempts (4% TFL%) in the Red Zone last season– worst in the Big Ten; Average: 14%.

Illinois has not allowed any rushing touchdowns on 84 rushes this season– T-best among Power Conference Teams; Average: 33.3

Indiana Defensive Stats & Trends

Indiana has allowed no passing TDs (63 pass attempts) this season– T-best in FBS; Average: 24.6

Indiana has tackled opponents for a loss on 27 of 86 rushing attempts (31% TFL%) this season– 2nd-best among Power Conference Teams; Average: 18%.

Indiana has tackled opponents for a loss on 117 of 466 rushing attempts (25% TFL%) since the 2024 season– best in FBS; Average: 16%.

Indiana sacked opposing QBs on 25% of pass attempts (5/20) last week– best in FBS; Average: 7%

Indiana has tackled opponents for a loss on 117 of 466 rushing attempts (25% TFL%) since the 2024 season– best among Power Conference Teams; Average: 17%.


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