E Michigan vs Buffalo U Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 6

Buffalo head coach Pete Lembo, left, watches his team during the second half of an NCAA college football game against Northern Illinois on Saturday, Sept. 21, 2024, in DeKalb, Ill. (AP Photo/Charles Rex Arbogast)
(AP Photo/Charles Rex Arbogast)
  • Buffalo U is a -10 point favorite vs. E Michigan
  • Eastern Michigan vs. Buffalo Total (Over/Under): 54.5 points
  • TV Channel: ESPN+

Eastern Michigan (1-4) visit UB Stadium to take on Buffalo (2-3) on Oct. 4 in Buffalo, NY. Kickoff is scheduled for 3:30pm EDT.

Buffalo U is a betting favorite in Week 6, with the spread sitting at -10 (-105).

The Eastern Michigan vs. Buffalo Over/Under is 54.5 total points.

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Eastern Michigan vs. Buffalo Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Eastern Michigan+10 -11554.5 -110290
Buffalo -10 -10554.5 -110-375

Eastern Michigan vs Buffalo Prediction:

The winning team model predicts Buffalo will win this game with 79.5% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both E Michigan and Buffalo U, key player performances this season and recent team trends.

Eastern Michigan vs Buffalo Spread Prediction:

Based on recent against-the-spread trends, the model predicts Buffalo will cover the spread with 70.0% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • Eastern Michigan has hit the Game Total Under in 4 of their last 6 away games (+1.80 Units / 27% ROI)
  • Eastern Michigan has hit the Team Total Over in 3 of their last 5 games (+0.85 Units / 15% ROI)
  • Eastern Michigan has hit the 1Q Game Total Under in 7 of their last 12 games (+0.80 Units / 5% ROI)
  • Eastern Michigan has hit the 1H Game Total Under in 3 of their last 6 away games (+0.75 Units / 11% ROI)
  • Buffalo have covered the 1Q Spread in 9 of their last 12 games (+5.80 Units / 38% ROI)
  • Buffalo has hit the 1Q Moneyline in 4 of their last 5 games at home (+4.65 Units / 44% ROI)
  • Buffalo has hit the 1H Game Total Under in 9 of their last 13 games (+4.55 Units / 31% ROI)
  • Buffalo have covered the 1H Spread in 9 of their last 13 games (+4.15 Units / 27% ROI)
  • Buffalo has hit the 1Q Game Total Under in 8 of their last 12 games (+3.40 Units / 24% ROI)

Eastern Michigan Against the Spread (ATS) Record

E Michigan is 2-3 against the spread this college football season (-1.3 Units / -23.64% ROI).

  • Eastern Michigan is 1-4 when betting on the Moneyline for -17.85 Units / -89.25% ROI
  • Eastern Michigan is 3-2 when betting the Over for +0.8 Units / 14.55% ROI
  • Eastern Michigan is 2-3 when betting the Under for -1.3 Units / -23.64% ROI

Buffalo Against the Spread (ATS) Record

Buffalo U iss 2-2 against the spread this college football season (-0.2 Units / -3.64% ROI).

  • Buffalo is 1-3 when betting on the Moneyline for -3.1 Units / -11.88% ROI
  • Buffalo is 2-3 when betting the Over for -1.3 Units / -23.64% ROI
  • Buffalo is 3-2 when betting the Under for +0.8 Units / 14.55% ROI

Eastern Michigan: Keys to the Game vs. Buffalo

Buffalo’s TEs has 15 receptions in 16 games (just 0.9 per game) since the 2024 season — T-5th-worst among FBS TEs. Eastern Michigan’s defense has allowed just 16.4 receptions per game since the 2024 season — T-16th-best among FBS defenses.

Buffalo has 258 receptions in 17 games (just 15.2 per game) since the 2024 season — T-21st-worst among FBS skill players. Eastern Michigan’s defense has allowed just 16.4 receptions per game since the 2024 season — T-16th-best among FBS defenses.

Buffalo’s RBs has averaged 9.7 yards after the catch since the 2024 season — 22nd-best among FBS RBs. Eastern Michigan’s defense has allowed 13.7 RAC since the 2024 season — worst among NonP5 defenses.

Buffalo TEs have averaged just 0.2 receptions per game (1/4) this season– 3rd-worst among FBS Teams; Average: 3.3

Buffalo RBs averaged 17.6 yards per reception (88 yards/5 catches) in the 4th quarter last season– T-3rd-best among FBS Teams; Average: 8.1

Buffalo: Keys to the Game vs. Eastern Michigan

Eastern Michigan is 1-6 (.143) when the opposing team commits less than 60 yards in penalties since the 2024 season– T-7th-worst in FBS; Average: .560

Eastern Michigan was 2-7 (.222) when allowing 120 or more rushing yards last season– T-39th-worst in FBS; Average: .379

Eastern Michigan is 3-7 (.300) when not forcing and recovering a fumble since the 2024 season– T-21st-worst in FBS; Average: .488

Eastern Michigan was 1-5 (.167) when throwing at least 1 interception last season– T-19th-worst in FBS; Average: .382

Matchup Notes for Eastern Michigan vs. Buffalo

Eastern Michigan is 1-6 (.143) when the opposing team commits less than 60 yards in penalties since the 2024 season– T-7th-worst in FBS; Average: .560

Eastern Michigan was 2-7 (.222) when allowing 120 or more rushing yards last season– T-39th-worst in FBS; Average: .379

Eastern Michigan is 3-7 (.300) when not forcing and recovering a fumble since the 2024 season– T-21st-worst in FBS; Average: .488

Eastern Michigan was 1-5 (.167) when throwing at least 1 interception last season– T-19th-worst in FBS; Average: .382

Buffalo’s TEs has 15 receptions in 16 games (just 0.9 per game) since the 2024 season — T-5th-worst among FBS TEs. Eastern Michigan’s defense has allowed just 16.4 receptions per game since the 2024 season — T-16th-best among FBS defenses.

Buffalo has 258 receptions in 17 games (just 15.2 per game) since the 2024 season — T-21st-worst among FBS skill players. Eastern Michigan’s defense has allowed just 16.4 receptions per game since the 2024 season — T-16th-best among FBS defenses.

Buffalo’s RBs has averaged 9.7 yards after the catch since the 2024 season — 22nd-best among FBS RBs. Eastern Michigan’s defense has allowed 13.7 RAC since the 2024 season — worst among NonP5 defenses.

Buffalo TEs have averaged just 0.2 receptions per game (1/4) this season– 3rd-worst among FBS Teams; Average: 3.3

Buffalo RBs averaged 17.6 yards per reception (88 yards/5 catches) in the 4th quarter last season– T-3rd-best among FBS Teams; Average: 8.1

Eastern Michigan Offensive Stats & Trends

Buffalo’s TEs has 15 receptions in 16 games (just 0.9 per game) since the 2024 season — T-5th-worst among FBS TEs. Eastern Michigan’s defense has allowed just 16.4 receptions per game since the 2024 season — T-16th-best among FBS defenses.

Buffalo has 258 receptions in 17 games (just 15.2 per game) since the 2024 season — T-21st-worst among FBS skill players. Eastern Michigan’s defense has allowed just 16.4 receptions per game since the 2024 season — T-16th-best among FBS defenses.

Buffalo’s RBs has averaged 9.7 yards after the catch since the 2024 season — 22nd-best among FBS RBs. Eastern Michigan’s defense has allowed 13.7 RAC since the 2024 season — worst among NonP5 defenses.

Buffalo TEs have averaged just 0.2 receptions per game (1/4) this season– 3rd-worst among FBS Teams; Average: 3.3

Buffalo RBs averaged 17.6 yards per reception (88 yards/5 catches) in the 4th quarter last season– T-3rd-best among FBS Teams; Average: 8.1

Buffalo Offensive Stats & Trends

Eastern Michigan is 1-6 (.143) when the opposing team commits less than 60 yards in penalties since the 2024 season– T-7th-worst in FBS; Average: .560

Eastern Michigan was 2-7 (.222) when allowing 120 or more rushing yards last season– T-39th-worst in FBS; Average: .379

Eastern Michigan is 3-7 (.300) when not forcing and recovering a fumble since the 2024 season– T-21st-worst in FBS; Average: .488

Eastern Michigan was 1-5 (.167) when throwing at least 1 interception last season– T-19th-worst in FBS; Average: .382

Eastern Michigan Defensive Stats & Trends

Buffalo’s TEs has 15 receptions in 16 games (just 0.9 per game) since the 2024 season — T-5th-worst among FBS TEs. Eastern Michigan’s defense has allowed just 16.4 receptions per game since the 2024 season — T-16th-best among FBS defenses.

Buffalo has 258 receptions in 17 games (just 15.2 per game) since the 2024 season — T-21st-worst among FBS skill players. Eastern Michigan’s defense has allowed just 16.4 receptions per game since the 2024 season — T-16th-best among FBS defenses.

Buffalo’s RBs has averaged 9.7 yards after the catch since the 2024 season — 22nd-best among FBS RBs. Eastern Michigan’s defense has allowed 13.7 RAC since the 2024 season — worst among NonP5 defenses.

Buffalo TEs have averaged just 0.2 receptions per game (1/4) this season– 3rd-worst among FBS Teams; Average: 3.3

Buffalo RBs averaged 17.6 yards per reception (88 yards/5 catches) in the 4th quarter last season– T-3rd-best among FBS Teams; Average: 8.1

Buffalo Defensive Stats & Trends

Eastern Michigan is 1-6 (.143) when the opposing team commits less than 60 yards in penalties since the 2024 season– T-7th-worst in FBS; Average: .560

Eastern Michigan was 2-7 (.222) when allowing 120 or more rushing yards last season– T-39th-worst in FBS; Average: .379

Eastern Michigan is 3-7 (.300) when not forcing and recovering a fumble since the 2024 season– T-21st-worst in FBS; Average: .488

Eastern Michigan was 1-5 (.167) when throwing at least 1 interception last season– T-19th-worst in FBS; Average: .382


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