- Duke is a -6 point favorite vs. Syracuse
- Duke vs. Syracuse Total (Over/Under): 60.5 points
- TV Channel: ACCN
Duke (2-2) visit JMA Wireless Dome to take on Syracuse (3-1) on Sep. 27 in Syracuse, NY. Kickoff is scheduled for 12:00pm EDT.
Duke is a betting favorite in Week 5, with the spread sitting at -6 (-110).
The Duke vs. Syracuse Over/Under is 60.5 total points.
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Duke vs. Syracuse Odds, Spread, Over/Under:
| Spread | Total (O/U) | Moneyline | |
| Duke | -6 -110 | 60.5 -115 | -225 |
| Syracuse | +6 -110 | 60.5 -105 | 185 |
Duke vs Syracuse Prediction:
The winning team model predicts Duke will win this game with 71.2% confidence, based on game simulations, offensive & defensive matchups and recent game results.
This winning team prediction factors in up-to-date player injuries for both Duke and Syracuse, key player performances this season and recent team trends.
Duke vs Syracuse Spread Prediction:
Based on recent against-the-spread trends, the model predicts Syracuse will cover the spread with 71.2% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
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Duke Best Bets Today
- Duke has hit the 1Q Game Total Over in 4 of their last 5 away games (+2.90 Units / 50% ROI)
- Duke has hit the Game Total Over in 8 of their last 13 games (+2.50 Units / 17% ROI)
- Duke has hit the 1H Moneyline in 2 of their last 6 away games (+2.15 Units / 33% ROI)
- Duke have covered the Spread in 7 of their last 13 games (+1.50 Units / 10% ROI)
- Duke has hit the 1Q Moneyline in 5 of their last 11 games (+0.65 Units / 2% ROI)
Syracuse Best Bets Today
- Syracuse has hit the Moneyline in 9 of their last 12 games (+16.40 Units / 65% ROI)
- Syracuse has hit the Game Total Over in 9 of their last 14 games (+4.60 Units / 30% ROI)
- Syracuse has hit the 1H Game Total Over in 9 of their last 14 games (+4.40 Units / 27% ROI)
- Syracuse has hit the 1H Moneyline in 6 of their last 12 games (+3.10 Units / 3% ROI)
- Syracuse has hit the 1Q Game Total Over in 7 of their last 12 games (+1.60 Units / 12% ROI)
Duke Against the Spread (ATS) Record
Duke is 1-3 against the spread this college football season (-2.3 Units / -52.27% ROI).
- Duke is 1-2 when betting on the Moneyline for -1 Units / -28.17% ROI
- Duke is 4-0 when betting the Over for +4 Units / 90.91% ROI
- Duke is 0-4 when betting the Under for -4.4 Units / -100% ROI
Syracuse Against the Spread (ATS) Record
Syracuse iss 2-1 against the spread this college football season (+0.9 Units / 20.45% ROI).
- Syracuse is 2-1 when betting on the Moneyline for +5.8 Units / 122.11% ROI
- Syracuse is 3-1 when betting the Over for +1.9 Units / 43.18% ROI
- Syracuse is 1-3 when betting the Under for -2.3 Units / -52.27% ROI
Duke: Keys to the Game vs. Syracuse
Duke have thrown for 6 TDs in the 3rd quarter this season– most among FBS Offenses
Duke’s offense has thrown for 1,327 passing yards in 4 games (331.8 YPG) this season — 10th-best among FBS offenses. Syracuse’s defense has allowed 296.2 passing yards per game this season — 3rd-worst among FBS defenses.
Duke’s offense has thrown for 20 or more yards on 13.8% of 152 attempts this season — T-27th-best among FBS offenses. Syracuse’s defense allowed 20+ yards on just 5.9% of attempts this season — 19th-best among FBS defenses.
Duke’s WRs has 286 receptions in 17 games (16.8 per game) since the 2024 season — 11th-best among FBS WRs. Syracuse’s defense has allowed 22.1 receptions per game since the 2024 season — 3rd-worst among ACC defenses.
Duke RBs have averaged 10.0 Yards per Carry (209 yards/21 carries) in the 4th quarter this season– 2nd-best among FBS Teams; Average: 5.3
Syracuse: Keys to the Game vs. Duke
Syracuse’s offense has thrown for 20 or more yards on 14.8% of 169 attempts this season — T-18th-best among FBS offenses. Duke’s defense allowed 20+ yards on 14.2% of attempts this season — 2nd-worst among ACC defenses.
Syracuse’s offense has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS offenses. Duke’s defense has allowed 260.5 passing yards per game this season — 24th-worst among FBS defenses.
Syracuse Skill Players have 8 receptions for 20 or more yards in the 4th quarter this season– T-most among FBS Teams
Syracuse Skill Players were targeted 44.8 times per game (583/13) last season– highest among Power Conference Teams; Average: 30.4
Syracuse has gained 1,406 yards on 103 receptions (13.7 YPR) this season — T-3rd-best among ACC skill players. Duke’s defense has allowed 13.2 Yards Per Reception this season — 20th-worst among FBS defenses.
Matchup Notes for Duke vs. Syracuse
Syracuse’s offense has thrown for 20 or more yards on 14.8% of 169 attempts this season — T-18th-best among FBS offenses. Duke’s defense allowed 20+ yards on 14.2% of attempts this season — 2nd-worst among ACC defenses.
Syracuse’s offense has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS offenses. Duke’s defense has allowed 260.5 passing yards per game this season — 24th-worst among FBS defenses.
Syracuse Skill Players have 8 receptions for 20 or more yards in the 4th quarter this season– T-most among FBS Teams
Syracuse Skill Players were targeted 44.8 times per game (583/13) last season– highest among Power Conference Teams; Average: 30.4
Syracuse has gained 1,406 yards on 103 receptions (13.7 YPR) this season — T-3rd-best among ACC skill players. Duke’s defense has allowed 13.2 Yards Per Reception this season — 20th-worst among FBS defenses.
Duke have thrown for 6 TDs in the 3rd quarter this season– most among FBS Offenses
Duke’s offense has thrown for 1,327 passing yards in 4 games (331.8 YPG) this season — 10th-best among FBS offenses. Syracuse’s defense has allowed 296.2 passing yards per game this season — 3rd-worst among FBS defenses.
Duke’s offense has thrown for 20 or more yards on 13.8% of 152 attempts this season — T-27th-best among FBS offenses. Syracuse’s defense allowed 20+ yards on just 5.9% of attempts this season — 19th-best among FBS defenses.
Duke’s WRs has 286 receptions in 17 games (16.8 per game) since the 2024 season — 11th-best among FBS WRs. Syracuse’s defense has allowed 22.1 receptions per game since the 2024 season — 3rd-worst among ACC defenses.
Duke RBs have averaged 10.0 Yards per Carry (209 yards/21 carries) in the 4th quarter this season– 2nd-best among FBS Teams; Average: 5.3
Duke Offensive Stats & Trends
Duke have thrown for 6 TDs in the 3rd quarter this season– most among FBS Offenses
Duke’s offense has thrown for 1,327 passing yards in 4 games (331.8 YPG) this season — 10th-best among FBS offenses. Syracuse’s defense has allowed 296.2 passing yards per game this season — 3rd-worst among FBS defenses.
Duke’s offense has thrown for 20 or more yards on 13.8% of 152 attempts this season — T-27th-best among FBS offenses. Syracuse’s defense allowed 20+ yards on just 5.9% of attempts this season — 19th-best among FBS defenses.
Duke’s WRs has 286 receptions in 17 games (16.8 per game) since the 2024 season — 11th-best among FBS WRs. Syracuse’s defense has allowed 22.1 receptions per game since the 2024 season — 3rd-worst among ACC defenses.
Duke RBs have averaged 10.0 Yards per Carry (209 yards/21 carries) in the 4th quarter this season– 2nd-best among FBS Teams; Average: 5.3
Syracuse Offensive Stats & Trends
Syracuse’s offense has thrown for 20 or more yards on 14.8% of 169 attempts this season — T-18th-best among FBS offenses. Duke’s defense allowed 20+ yards on 14.2% of attempts this season — 2nd-worst among ACC defenses.
Syracuse’s offense has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS offenses. Duke’s defense has allowed 260.5 passing yards per game this season — 24th-worst among FBS defenses.
Syracuse Skill Players have 8 receptions for 20 or more yards in the 4th quarter this season– T-most among FBS Teams
Syracuse Skill Players were targeted 44.8 times per game (583/13) last season– highest among Power Conference Teams; Average: 30.4
Syracuse has gained 1,406 yards on 103 receptions (13.7 YPR) this season — T-3rd-best among ACC skill players. Duke’s defense has allowed 13.2 Yards Per Reception this season — 20th-worst among FBS defenses.
Duke Defensive Stats & Trends
Duke have thrown for 6 TDs in the 3rd quarter this season– most among FBS Offenses
Duke’s offense has thrown for 1,327 passing yards in 4 games (331.8 YPG) this season — 10th-best among FBS offenses. Syracuse’s defense has allowed 296.2 passing yards per game this season — 3rd-worst among FBS defenses.
Duke’s offense has thrown for 20 or more yards on 13.8% of 152 attempts this season — T-27th-best among FBS offenses. Syracuse’s defense allowed 20+ yards on just 5.9% of attempts this season — 19th-best among FBS defenses.
Duke’s WRs has 286 receptions in 17 games (16.8 per game) since the 2024 season — 11th-best among FBS WRs. Syracuse’s defense has allowed 22.1 receptions per game since the 2024 season — 3rd-worst among ACC defenses.
Duke RBs have averaged 10.0 Yards per Carry (209 yards/21 carries) in the 4th quarter this season– 2nd-best among FBS Teams; Average: 5.3
Syracuse Defensive Stats & Trends
Syracuse’s offense has thrown for 20 or more yards on 14.8% of 169 attempts this season — T-18th-best among FBS offenses. Duke’s defense allowed 20+ yards on 14.2% of attempts this season — 2nd-worst among ACC defenses.
Syracuse’s offense has thrown for 1,416 passing yards in 4 games (354.0 YPG) this season — 4th-best among FBS offenses. Duke’s defense has allowed 260.5 passing yards per game this season — 24th-worst among FBS defenses.
Syracuse Skill Players have 8 receptions for 20 or more yards in the 4th quarter this season– T-most among FBS Teams
Syracuse Skill Players were targeted 44.8 times per game (583/13) last season– highest among Power Conference Teams; Average: 30.4
Syracuse has gained 1,406 yards on 103 receptions (13.7 YPR) this season — T-3rd-best among ACC skill players. Duke’s defense has allowed 13.2 Yards Per Reception this season — 20th-worst among FBS defenses.
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