Colorado St vs San Diego St Prediction, Odds & Best Prop Bets – NCAAF, Week 6

BetMGM Betting Oct 02, 2025, 2:40 PM

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(AP Photo/Doug McSchooler)

San Diego St is a -6 point favorite vs. Colorado St
Colorado State vs. San Diego State Total (Over/Under): 40.5 points
TV Channel: CBSN

Colorado State (1-3) visit Snapdragon Stadium to take on San Diego State (3-1) on Oct. 3 in San Diego, CA. Kickoff is scheduled for 10:30pm EDT.

San Diego St is a betting favorite in Week 6, with the spread sitting at -6 (-115).

The Colorado State vs. San Diego State Over/Under is 40.5 total points.

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Colorado State vs. San Diego State Odds, Spread, Over/Under:

	Spread	Total (O/U)	Moneyline
Colorado State	+6 -105	40.5 -105	190
San Diego State	-6 -115	40.5 -115	-235

Colorado State vs San Diego State Prediction:

The winning team model predicts San Diego State will win this game with 66.8% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Colorado St and San Diego St, key player performances this season and recent team trends.

Colorado State vs San Diego State Spread Prediction:

Based on recent against-the-spread trends, the model predicts San Diego State will cover the spread with 65.0% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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Colorado State Best Bets Today

Colorado State have covered the Spread in 8 of their last 13 games (+3.60 Units / 25% ROI)
Colorado State has hit the Game Total Over in 4 of their last 5 away games (+2.90 Units / 53% ROI)
Colorado State have covered the 1H Spread in 4 of their last 5 away games (+2.90 Units / 52% ROI)
Colorado State has hit the 1H Game Total Under in 8 of their last 13 games (+2.25 Units / 15% ROI)
Colorado State has hit the 1Q Game Total Over in 7 of their last 12 games (+1.55 Units / 12% ROI)

San Diego State Best Bets Today

San Diego State has hit the Moneyline in 3 of their last 6 games at home (+3.00 Units / 18% ROI)
San Diego State have covered the 1H Spread in 4 of their last 6 games at home (+2.90 Units / 43% ROI)
San Diego State has hit the 1Q Game Total Over in 3 of their last 5 games at home (+2.00 Units / 34% ROI)
San Diego State has hit the Game Total Under in 4 of their last 6 games at home (+1.80 Units / 27% ROI)
San Diego State have covered the Spread in 4 of their last 6 games at home (+1.80 Units / 27% ROI)

Colorado State Against the Spread (ATS) Record

Colorado St is 2-2 against the spread this college football season (-0.2 Units / -4.55% ROI).

Colorado State is 0-3 when betting on the Moneyline for -4 Units / -100% ROI
Colorado State is 1-3 when betting the Over for -2.3 Units / -52.27% ROI
Colorado State is 3-1 when betting the Under for +1.9 Units / 43.18% ROI

San Diego State Against the Spread (ATS) Record

San Diego St iss 3-1 against the spread this college football season (+1.9 Units / 43.18% ROI).

San Diego State is 3-1 when betting on the Moneyline for +5.2 Units / 36.49% ROI
San Diego State is 1-3 when betting the Over for -2.3 Units / -52.27% ROI
San Diego State is 3-1 when betting the Under for +1.9 Units / 43.18% ROI

Colorado State: Keys to the Game vs. San Diego State

San Diego State was 1-9 (.100) when allowing more than 3 explosive runs last season– T-6th-worst among Non-Power Conference Teams; Average: .372

San Diego State was winless (0-6) when their opponent committed less than 60 yards in penalties last season– T-worst in FBS; Average: .536

San Diego State was winless (0-6) when their opponent committed less than 60 yards in penalties last season– T-worst among Non-Power Conference Teams; Average: .477

San Diego State was 1-4 (.200) when throwing at least 1 interception last season– 29th-worst in FBS; Average: .382

San Diego State: Keys to the Game vs. Colorado State

San Diego State’s WRs has averaged just 12.0 yards after the catch since the 2024 season — T-20th-worst among FBS WRs. Colorado State’s defense has allowed just 12.2 RAC to WRs since the 2024 season — T-34th-best among FBS defenses.

San Diego State Skill Players have averaged a touchdown every 3.4 receptions (24 Rec/7 TDs) in the Red Zone since the 2024 season– T-5th-worst Receptions Per TD among FBS Teams; Average: 2.1

San Diego State RBs averaged just 4.4 Yards per Carry (1,427 yards/324 carries) last season– T-21st-worst among FBS Teams; Average: 5.1

San Diego State Skill Players have averaged just 15.3 receptions per game (46/3) this season– 25th-worst among FBS Teams; Average: 19.3

San Diego State WRs had no touchdowns on 6 receptions in the Red Zone in the 2023 season– T-worst Receptions Per TD among FBS Teams; Average: 1.9

Matchup Notes for Colorado State vs. San Diego State