Clemson vs North Carolina Prediction, Odds & Best Prop Bets – NCAAF, Week 6

BetMGM Betting Oct 02, 2025, 2:40 PM

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New North Carolina football coach Bill Belichick holds up a UNC branded sleeveless hoodie presented to him during an NCAA college football news conference announcing his hiring, Dec. 12, 2024, in Chapel Hill, N.C.

(AP Photo/Ben McKeown)

Clemson is a -14 point favorite vs. North Carolina
Clemson vs. North Carolina Total (Over/Under): 46.5 points
TV Channel: ESPN

Clemson (1-3) visit Kenan Stadium to take on North Carolina (2-2) on Oct. 4 in Chapel Hill, NC. Kickoff is scheduled for 12:00pm EDT.

Clemson is a betting favorite in Week 6, with the spread sitting at -14 (-110).

The Clemson vs. North Carolina Over/Under is 46.5 total points.

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Clemson vs. North Carolina Odds, Spread, Over/Under:

	Spread	Total (O/U)	Moneyline
Clemson	-14 -110	46.5 -105	-600
North Carolina	+14 -110	46.5 -115	425

Clemson vs North Carolina Prediction:

The winning team model predicts Clemson will win this game with 79.0% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Clemson and North Carolina, key player performances this season and recent team trends.

Clemson vs North Carolina Spread Prediction:

Based on recent against-the-spread trends, the model predicts North Carolina will cover the spread with 70.2% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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Clemson Best Bets Today

Clemson has hit the 1Q Game Total Under in 8 of their last 12 games (+3.10 Units / 22% ROI)
Clemson has hit the Moneyline in 5 of their last 7 away games (+2.75 Units / 9% ROI)
Clemson has hit the 1H Game Total Under in 8 of their last 13 games (+2.50 Units / 17% ROI)
Clemson has hit the Game Total Under in 8 of their last 14 games (+2.50 Units / 16% ROI)
Clemson have covered the 1H Spread in 4 of their last 7 away games (+0.50 Units / 6% ROI)

North Carolina Best Bets Today

North Carolina has hit the Game Total Under in 8 of their last 12 games (+3.60 Units / 27% ROI)
North Carolina has hit the 1Q Game Total Under in 7 of their last 11 games (+2.55 Units / 19% ROI)
North Carolina has hit the 1H Game Total Under in 6 of their last 12 games (+0.40 Units / 3% ROI)

Clemson Against the Spread (ATS) Record

Clemson is 0-4 against the spread this college football season (-4.35 Units / -100% ROI).

Clemson is 0-3 when betting on the Moneyline for -11.45 Units / -100% ROI
Clemson is 1-3 when betting the Over for -2.3 Units / -52.27% ROI
Clemson is 3-1 when betting the Under for +1.9 Units / 43.18% ROI

North Carolina Against the Spread (ATS) Record

North Carolina iss 2-2 against the spread this college football season (-0.2 Units / -4.55% ROI).

North Carolina is 2-2 when betting on the Moneyline for +0 Units / 0% ROI
North Carolina is 1-3 when betting the Over for -2.3 Units / -52.27% ROI
North Carolina is 3-1 when betting the Under for +1.9 Units / 43.18% ROI

Clemson: Keys to the Game vs. North Carolina

Clemson RBs averaged 8.9 yards from scrimmage per touch (277 yards / 31 touches) on 3rd and short last season– best among FBS Teams; Average: 4.4

Clemson Skill Players have been targeted 48 times in the 4th quarter this season– most among Power Conference Teams

Clemson have thrown for 13 TDs in the 3rd quarter since the 2024 season– T-most among FBS Offenses

Clemson Skill Players have been targeted 48 times in the 4th quarter this season– 3rd-most among FBS Teams

Clemson TEs have been targeted 5.3 times per game (16/3) in the 2nd half this season– T-2nd-highest among FBS Teams; Average: 2.6

North Carolina: Keys to the Game vs. Clemson

Clemson was undefeated (7-0) when allowing less than 5 yards per rush last season– T-best in FBS; Average: .632

Clemson was undefeated (7-0) when allowing less than 5 yards per rush last season– T-best among Power Conference Teams; Average: .647

Clemson was 9-3 (.750) when making 7 or more explosive plays last season– T-34th-best in FBS; Average: .628

Clemson was 8-2 (.800) when allowing less than 50% of third down conversion opportunities last season– T-27th-best in FBS; Average: .602

Matchup Notes for Clemson vs. North Carolina