Clemson vs Louisville Prediction, Odds & Best Prop Bets – NCAAF, Week 12

BetMGM Betting Nov 14, 2025, 11:34 AM

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FILE - Louisville head coach Jeff Brohm shouts instructions to his team during the first half of an NCAA college football game in Louisville, Ky., Saturday, Sept. 23, 2023. Louisville enters without Jack Plummer, who led Jeff Brohm's first-year program to its first ACC title game berth. (AP Photo/Timothy D. Easley, FIle)

(AP Photo/Timothy D. Easley)

Louisville is a -3 point favorite vs. Clemson
Clemson vs. Louisville Total (Over/Under): 50.5 points
TV Channel: ESPN

Clemson (4-5) visit L&N Federal Credit Union Stadium to take on Louisville (7-2) on Nov. 14 in Louisville, KY. Kickoff is scheduled for 7:30pm EST.

Louisville is a betting favorite in Week 12, with the spread sitting at -3 (-110).

The Clemson vs. Louisville Over/Under is 50.5 total points.

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Clemson vs. Louisville Odds, Spread, Over/Under:

	Spread	Total (O/U)	Moneyline
Clemson	+3 -110	50.5 -105	120
Louisville	-3 -110	50.5 -115	-145

Clemson vs Louisville Prediction:

The winning team model predicts Louisville will win this game with 59.8% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Clemson and Louisville, key player performances this season and recent team trends.

Clemson vs Louisville Spread Prediction:

Based on recent against-the-spread trends, the model predicts Clemson will cover the spread with 52.1% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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Clemson Best Bets Today

Clemson has hit the 1Q Game Total Over in 5 of their last 6 away games (+4.15 Units / 62% ROI)
Clemson has hit the Team Total Under in 6 of their last 9 games (+2.45 Units / 24% ROI)
Clemson have covered the 1Q Spread in 4 of their last 6 away games (+1.95 Units / 28% ROI)
Clemson has hit the 1H Moneyline in 4 of their last 6 away games (+1.80 Units / 11% ROI)
Clemson has hit the Moneyline in 4 of their last 6 away games (+1.75 Units / 9% ROI)

Louisville Best Bets Today

Louisville has hit the Team Total Under in 4 of their last 5 games (+2.90 Units / 53% ROI)
Louisville has hit the 1Q Game Total Over in 8 of their last 13 games (+2.65 Units / 18% ROI)
Louisville has hit the Game Total Over in 8 of their last 13 games (+2.50 Units / 17% ROI)
Louisville has hit the 1Q Moneyline in 4 of their last 7 games at home (+1.20 Units / 3% ROI)
Louisville has hit the 1H Game Total Under in 4 of their last 7 games at home (+0.50 Units / 6% ROI)

Clemson Against the Spread (ATS) Record

Clemson is 3-6 against the spread this college football season (-3.55 Units / -36.04% ROI).

Clemson is 3-5 when betting on the Moneyline for -11.95 Units / -42.6% ROI
Clemson is 3-5 when betting the Over for -2.5 Units / -25.13% ROI
Clemson is 5-3 when betting the Under for +1.75 Units / 17.77% ROI

Louisville Against the Spread (ATS) Record

Louisville iss 3-6 against the spread this college football season (-3.6 Units / -36.36% ROI).

Louisville is 7-2 when betting on the Moneyline for -2.95 Units / -2.46% ROI
Louisville is 5-4 when betting the Over for +0.6 Units / 6.06% ROI
Louisville is 4-5 when betting the Under for -1.5 Units / -15.15% ROI

Clemson: Keys to the Game vs. Louisville

Clemson RBs averaged 8.9 yards from scrimmage per touch (277 yards / 31 touches) on 3rd and short last season– best among FBS Teams; Average: 4.4

Clemson have averaged a touchdown every 4.3 receptions (13 Rec/3 TDs) in the Red Zone this season– 7th-worst Receptions Per TD among FBS Offenses; Average: 2.0

Clemson have thrown 3 TDs on 28 pass attempts (one TD every 9.3 Pass Attempts) in the Red Zone this season– 8th-worst among FBS Offenses; Average: 3.6

Clemson’s offense has thrown for 2,211 passing yards in 8 games (276.4 YPG) this season — 22nd-best among FBS offenses. Louisville’s defense has allowed just 202.1 passing yards per game this season — 4th-best among ACC defenses.

Clemson Skill Players have averaged a touchdown every 4.3 receptions (13 Rec/3 TDs) in the Red Zone this season– 5th-worst Receptions Per TD among Power Conference Teams; Average: 2.1

Louisville: Keys to the Game vs. Clemson

Clemson was undefeated (7-0) when allowing less than 5 yards per rush last season– T-best among Power Conference Teams; Average: .647

Clemson was 9-3 (.750) when making 7 or more explosive plays last season– T-34th-best in FBS; Average: .628

Clemson was 5-2 (.714) when their opponent rushed more than 30 times last season– 15th-best among Power Conference Teams; Average: .481

Clemson was 10-2 (.833) when making 5 or more explosive passes in a game last season– T-9th-best among Power Conference Teams; Average: .631

Matchup Notes for Clemson vs. Louisville