BYU vs Colorado Prediction, Odds & Best Prop Bets – NCAAF, Week 5

BetMGM Betting Sep 26, 2025, 10:13 AM

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Colorado head coach Deion Sanders in the first half of the team's spring practice NCAA college football game Saturday, April 22, 2023, in Boulder, Colo.

(AP Photo/David Zalubowski)

BYU is a -6.5 point favorite vs. Colorado
BYU vs. Colorado Total (Over/Under): 48.5 points
TV Channel: ESPN

BYU (3-0) visit Folsom Field to take on Colorado (2-2) on Sep. 27 in Boulder, CO. Kickoff is scheduled for 10:15pm EDT.

BYU is a betting favorite in Week 5, with the spread sitting at -6.5 (-115).

The BYU vs. Colorado Over/Under is 48.5 total points.

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BYU vs. Colorado Odds, Spread, Over/Under:

	Spread	Total (O/U)	Moneyline
BYU	-6.5 -115	48.5 -110	-250
Colorado	+6.5 -105	48.5 -110	200

BYU vs Colorado Prediction:

The winning team model predicts BYU will win this game with 66.9% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both BYU and Colorado, key player performances this season and recent team trends.

BYU vs Colorado Spread Prediction:

Based on recent against-the-spread trends, the model predicts BYU will cover the spread with 59.6% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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BYU Best Bets Today

BYU has hit the Moneyline in 9 of their last 11 games (+7.40 Units / 23% ROI)
BYU has hit the 1Q Game Total Under in 9 of their last 12 games (+5.55 Units / 38% ROI)
BYU has hit the Game Total Over in 8 of their last 12 games (+3.60 Units / 27% ROI)
BYU have covered the 1H Spread in 8 of their last 12 games (+3.45 Units / 25% ROI)
BYU has hit the 1Q Moneyline in 4 of their last 6 away games (+3.25 Units / 48% ROI)

Colorado Best Bets Today

Colorado has hit the Moneyline in 8 of their last 13 games (+4.80 Units / 9% ROI)
Colorado have covered the Spread in 9 of their last 13 games (+4.60 Units / 32% ROI)
Colorado has hit the 1Q Moneyline in 5 of their last 7 games at home (+3.60 Units / 19% ROI)
Colorado have covered the 1Q Spread in 5 of their last 8 games at home (+2.90 Units / 31% ROI)
Colorado has hit the 1H Moneyline in 7 of their last 13 games (+1.50 Units / 4% ROI)

BYU Against the Spread (ATS) Record

BYU is 3-0 against the spread this college football season (+3 Units / 90.91% ROI).

BYU is 2-0 when betting on the Moneyline for +2 Units / 12.23% ROI
BYU is 1-2 when betting the Over for -1.2 Units / -36.36% ROI
BYU is 2-1 when betting the Under for +0.9 Units / 27.27% ROI

Colorado Against the Spread (ATS) Record

Colorado iss 2-2 against the spread this college football season (-0.2 Units / -4.55% ROI).

Colorado is 2-2 when betting on the Moneyline for +0 Units / 0% ROI
Colorado is 2-2 when betting the Over for -0.2 Units / -4.55% ROI
Colorado is 2-2 when betting the Under for -0.2 Units / -4.55% ROI

BYU: Keys to the Game vs. Colorado

BYU’s TEs has gained 151 yards on 10 receptions (15.1 YPR) this season — 2nd-best among Big 12 TEs. Colorado’s defense has allowed 14.6 Yards Per Reception this season — 2nd-worst among P5 defenses.

BYU has averaged 13.4 yards after the catch since the 2024 season — 2nd-best among Big 12 skill players. Colorado’s defense has allowed 12.0 RAC since the 2024 season — 5th-worst among Big 12 defenses.

BYU has 263 receptions in 16 games (just 16.4 per game) since the 2024 season — 32nd-worst among FBS skill players. Colorado’s defense has allowed just 16.8 receptions per game since the 2024 season — T-4th-best among Big 12 defenses.

BYU’s TEs has gained 151 yards on 10 receptions (15.1 YPR) this season — 2nd-best among Big 12 TEs. Colorado’s defense has allowed 14.6 Yards Per Reception this season — 5th-worst among FBS defenses.

BYU has 263 receptions in 16 games (just 16.4 per game) since the 2024 season — 4th-worst among Big 12 skill players. Colorado’s defense has allowed just 16.8 receptions per game since the 2024 season — T-4th-best among Big 12 defenses.

Colorado: Keys to the Game vs. BYU

Colorado have averaged 22.2 yards per completion (377 yards/17 completions) on 3rd down this season– 2nd-best among FBS Offenses; Average: 12.0

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among FBS Teams; Average: 12.3

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among Power Conference Teams; Average: 12.6

Colorado have averaged 17.7 yards per completion (1,486 yards/84 completions) on 3rd down since the 2024 season– best among FBS Offenses; Average: 12.0

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among Big 12 Teams; Average: 13.2

Matchup Notes for BYU vs. Colorado

Colorado have averaged 22.2 yards per completion (377 yards/17 completions) on 3rd down this season– 2nd-best among FBS Offenses; Average: 12.0

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among FBS Teams; Average: 12.3

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among Power Conference Teams; Average: 12.6

Colorado have averaged 17.7 yards per completion (1,486 yards/84 completions) on 3rd down since the 2024 season– best among FBS Offenses; Average: 12.0

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among Big 12 Teams; Average: 13.2

BYU Offensive Stats & Trends

Colorado Offensive Stats & Trends

Colorado have averaged 22.2 yards per completion (377 yards/17 completions) on 3rd down this season– 2nd-best among FBS Offenses; Average: 12.0

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among FBS Teams; Average: 12.3

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among Power Conference Teams; Average: 12.6

Colorado have averaged 17.7 yards per completion (1,486 yards/84 completions) on 3rd down since the 2024 season– best among FBS Offenses; Average: 12.0

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among Big 12 Teams; Average: 13.2

BYU Defensive Stats & Trends

Colorado Defensive Stats & Trends

Colorado have averaged 22.2 yards per completion (377 yards/17 completions) on 3rd down this season– 2nd-best among FBS Offenses; Average: 12.0

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among FBS Teams; Average: 12.3

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among Power Conference Teams; Average: 12.6

Colorado have averaged 17.7 yards per completion (1,486 yards/84 completions) on 3rd down since the 2024 season– best among FBS Offenses; Average: 12.0

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among Big 12 Teams; Average: 13.2

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