Arizona vs Iowa St Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 5

Iowa State head coach Matt Campbell walks off the field after an NCAA college football game against Oklahoma, Saturday, Oct. 29, 2022, in Ames, Iowa. Oklahoma won 27-13. (AP Photo/Charlie Neibergall)
(AP Photo/Charlie Neibergall)
  • Iowa St is a -6.5 point favorite vs. Arizona
  • Arizona vs. Iowa State Total (Over/Under): 48.5 points
  • TV Channel: ESPN

Arizona (3-0) visit Jack Trice Stadium to take on Iowa State (4-0) on Sep. 27 in Ames, IA. Kickoff is scheduled for 7:00pm EDT.

Iowa St is a betting favorite in Week 5, with the spread sitting at -6.5 (-115).

The Arizona vs. Iowa State Over/Under is 48.5 total points.

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Arizona vs. Iowa State Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Arizona+6.5 -10548.5 -105200
Iowa State -6.5 -11548.5 -115-250

Arizona vs Iowa State Prediction:

The winning team model predicts Iowa State will win this game with 68.2% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Arizona and Iowa St, key player performances this season and recent team trends.

Arizona vs Iowa State Spread Prediction:

Based on recent against-the-spread trends, the model predicts Iowa State will cover the spread with 65.0% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • Arizona has hit the Game Total Under in 7 of their last 12 games (+1.50 Units / 11% ROI)
  • Arizona has hit the 1H Game Total Under in 7 of their last 12 games (+1.30 Units / 10% ROI)
  • Arizona has hit the 1Q Moneyline in 6 of their last 11 games (+1.20 Units / 6% ROI)
  • Arizona has hit the 1Q Game Total Under in 6 of their last 11 games (+0.55 Units / 4% ROI)
  • Iowa State has hit the Moneyline in 12 of their last 15 games (+5.30 Units / 9% ROI)
  • Iowa State has hit the 1Q Game Total Over in 4 of their last 6 games at home (+2.95 Units / 43% ROI)
  • Iowa State has hit the 1H Game Total Over in 5 of their last 7 games at home (+2.60 Units / 32% ROI)
  • Iowa State has hit the 1Q Moneyline in 8 of their last 12 games (+2.05 Units / 8% ROI)
  • Iowa State have covered the Spread in 4 of their last 7 games at home (+1.80 Units / 23% ROI)

Arizona Against the Spread (ATS) Record

Arizona is 3-0 against the spread this college football season (+3 Units / 90.91% ROI).

  • Arizona is 2-0 when betting on the Moneyline for +2 Units / 27.21% ROI
  • Arizona is 0-3 when betting the Over for -3.3 Units / -100% ROI
  • Arizona is 3-0 when betting the Under for +3 Units / 90.91% ROI

Iowa State Against the Spread (ATS) Record

Iowa St iss 2-1 against the spread this college football season (+0.9 Units / 20.45% ROI).

  • Iowa State is 4-0 when betting on the Moneyline for +4.3 Units / 17.1% ROI
  • Iowa State is 1-3 when betting the Over for -2.3 Units / -52.27% ROI
  • Iowa State is 3-1 when betting the Under for +1.9 Units / 43.18% ROI

Arizona: Keys to the Game vs. Iowa State

Arizona TEs averaged 23.2 yards per reception (93 yards/4 catches) on 3rd and long last season– best among Big 12 Teams; Average: 12.2

Arizona’s offense has thrown for 20 or more yards on 15.3% of 85 attempts this season — T-16th-best among FBS offenses. Iowa State’s defense allowed 20+ yards on 8.6% of attempts this season — 5th-worst among Big 12 defenses.

Arizona have been sacked on 23% of pass attempts (3/13) in the 4th quarter this season– worst among Big 12 Offenses; Average: 6%

Arizona’s TEs has 39 receptions in 15 games (just 2.6 per game) since the 2024 season — T-3rd-worst among Big 12 TEs. Iowa State’s defense has allowed just 14.7 receptions per game since the 2024 season — 2nd-best among P5 defenses.

Arizona TEs had no touchdowns on 3 receptions in the Red Zone last season– worst Receptions Per TD among Big 12 Teams; Average: 1.9

Iowa State: Keys to the Game vs. Arizona

Iowa State have thrown 0 TDs on 26 pass attempts (one TD every inf Pass Attempts) in the 4th quarter this season– T-2nd-worst among FBS Offenses; Average: 18.3

Iowa State’s WRs has gained 459 yards on 28 receptions (16.4 YPR) this season — 2nd-best among Big 12 WRs. Arizona’s defense has allowed just 7.7 Yards Per Reception this season — T-2nd-best among P5 defenses.

Iowa State’s TEs has gained 372 yards on 30 receptions (12.4 YPR) this season — 5th-best among Big 12 TEs. Arizona’s defense has allowed just 7.7 Yards Per Reception this season — T-best among Big 12 defenses.

Iowa State’s TEs has gained 372 yards on 30 receptions (12.4 YPR) this season — 5th-best among Big 12 TEs. Arizona’s defense has allowed just 4.0 Yards Per Reception to TEs this season — 2nd-best among FBS defenses.

Iowa State’s TEs has gained 372 yards on 30 receptions (12.4 YPR) this season — 5th-best among Big 12 TEs. Arizona’s defense has allowed just 7.7 Yards Per Reception this season — T-2nd-best among FBS defenses.

Matchup Notes for Arizona vs. Iowa State

Iowa State have thrown 0 TDs on 26 pass attempts (one TD every inf Pass Attempts) in the 4th quarter this season– T-2nd-worst among FBS Offenses; Average: 18.3

Iowa State’s WRs has gained 459 yards on 28 receptions (16.4 YPR) this season — 2nd-best among Big 12 WRs. Arizona’s defense has allowed just 7.7 Yards Per Reception this season — T-2nd-best among P5 defenses.

Iowa State’s TEs has gained 372 yards on 30 receptions (12.4 YPR) this season — 5th-best among Big 12 TEs. Arizona’s defense has allowed just 7.7 Yards Per Reception this season — T-best among Big 12 defenses.

Iowa State’s TEs has gained 372 yards on 30 receptions (12.4 YPR) this season — 5th-best among Big 12 TEs. Arizona’s defense has allowed just 4.0 Yards Per Reception to TEs this season — 2nd-best among FBS defenses.

Iowa State’s TEs has gained 372 yards on 30 receptions (12.4 YPR) this season — 5th-best among Big 12 TEs. Arizona’s defense has allowed just 7.7 Yards Per Reception this season — T-2nd-best among FBS defenses.

Arizona TEs averaged 23.2 yards per reception (93 yards/4 catches) on 3rd and long last season– best among Big 12 Teams; Average: 12.2

Arizona’s offense has thrown for 20 or more yards on 15.3% of 85 attempts this season — T-16th-best among FBS offenses. Iowa State’s defense allowed 20+ yards on 8.6% of attempts this season — 5th-worst among Big 12 defenses.

Arizona have been sacked on 23% of pass attempts (3/13) in the 4th quarter this season– worst among Big 12 Offenses; Average: 6%

Arizona’s TEs has 39 receptions in 15 games (just 2.6 per game) since the 2024 season — T-3rd-worst among Big 12 TEs. Iowa State’s defense has allowed just 14.7 receptions per game since the 2024 season — 2nd-best among P5 defenses.

Arizona TEs had no touchdowns on 3 receptions in the Red Zone last season– worst Receptions Per TD among Big 12 Teams; Average: 1.9

Arizona Offensive Stats & Trends

Arizona TEs averaged 23.2 yards per reception (93 yards/4 catches) on 3rd and long last season– best among Big 12 Teams; Average: 12.2

Arizona’s offense has thrown for 20 or more yards on 15.3% of 85 attempts this season — T-16th-best among FBS offenses. Iowa State’s defense allowed 20+ yards on 8.6% of attempts this season — 5th-worst among Big 12 defenses.

Arizona have been sacked on 23% of pass attempts (3/13) in the 4th quarter this season– worst among Big 12 Offenses; Average: 6%

Arizona’s TEs has 39 receptions in 15 games (just 2.6 per game) since the 2024 season — T-3rd-worst among Big 12 TEs. Iowa State’s defense has allowed just 14.7 receptions per game since the 2024 season — 2nd-best among P5 defenses.

Arizona TEs had no touchdowns on 3 receptions in the Red Zone last season– worst Receptions Per TD among Big 12 Teams; Average: 1.9

Iowa State Offensive Stats & Trends

Iowa State have thrown 0 TDs on 26 pass attempts (one TD every inf Pass Attempts) in the 4th quarter this season– T-2nd-worst among FBS Offenses; Average: 18.3

Iowa State’s WRs has gained 459 yards on 28 receptions (16.4 YPR) this season — 2nd-best among Big 12 WRs. Arizona’s defense has allowed just 7.7 Yards Per Reception this season — T-2nd-best among P5 defenses.

Iowa State’s TEs has gained 372 yards on 30 receptions (12.4 YPR) this season — 5th-best among Big 12 TEs. Arizona’s defense has allowed just 7.7 Yards Per Reception this season — T-best among Big 12 defenses.

Iowa State’s TEs has gained 372 yards on 30 receptions (12.4 YPR) this season — 5th-best among Big 12 TEs. Arizona’s defense has allowed just 4.0 Yards Per Reception to TEs this season — 2nd-best among FBS defenses.

Iowa State’s TEs has gained 372 yards on 30 receptions (12.4 YPR) this season — 5th-best among Big 12 TEs. Arizona’s defense has allowed just 7.7 Yards Per Reception this season — T-2nd-best among FBS defenses.

Arizona Defensive Stats & Trends

Arizona TEs averaged 23.2 yards per reception (93 yards/4 catches) on 3rd and long last season– best among Big 12 Teams; Average: 12.2

Arizona’s offense has thrown for 20 or more yards on 15.3% of 85 attempts this season — T-16th-best among FBS offenses. Iowa State’s defense allowed 20+ yards on 8.6% of attempts this season — 5th-worst among Big 12 defenses.

Arizona have been sacked on 23% of pass attempts (3/13) in the 4th quarter this season– worst among Big 12 Offenses; Average: 6%

Arizona’s TEs has 39 receptions in 15 games (just 2.6 per game) since the 2024 season — T-3rd-worst among Big 12 TEs. Iowa State’s defense has allowed just 14.7 receptions per game since the 2024 season — 2nd-best among P5 defenses.

Arizona TEs had no touchdowns on 3 receptions in the Red Zone last season– worst Receptions Per TD among Big 12 Teams; Average: 1.9

Iowa State Defensive Stats & Trends

Iowa State have thrown 0 TDs on 26 pass attempts (one TD every inf Pass Attempts) in the 4th quarter this season– T-2nd-worst among FBS Offenses; Average: 18.3

Iowa State’s WRs has gained 459 yards on 28 receptions (16.4 YPR) this season — 2nd-best among Big 12 WRs. Arizona’s defense has allowed just 7.7 Yards Per Reception this season — T-2nd-best among P5 defenses.

Iowa State’s TEs has gained 372 yards on 30 receptions (12.4 YPR) this season — 5th-best among Big 12 TEs. Arizona’s defense has allowed just 7.7 Yards Per Reception this season — T-best among Big 12 defenses.

Iowa State’s TEs has gained 372 yards on 30 receptions (12.4 YPR) this season — 5th-best among Big 12 TEs. Arizona’s defense has allowed just 4.0 Yards Per Reception to TEs this season — 2nd-best among FBS defenses.

Iowa State’s TEs has gained 372 yards on 30 receptions (12.4 YPR) this season — 5th-best among Big 12 TEs. Arizona’s defense has allowed just 7.7 Yards Per Reception this season — T-2nd-best among FBS defenses.


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