Fairleigh Dickinson’s win over Purdue in the 2023 NCAA Tournament is the biggest underdog win in NCAA Tournament history. From a college basketball odds standpoint, no March Madness upset has ever been bigger.
As a 16-seed, the Knights were a 23-point underdog when they shocked the Boilermakers. It was only the second-ever 16-over-1 upset in March Madness history.
Biggest Underdogs to Win March Madness Games
| Year | Underdog | Favorite | Spread |
| 2023 | (16) Fairleigh Dickinson | (1) Purdue | +23 |
| 2012 | (15) Norfolk State | (2) Missouri | +21 |
| 2018 | (16) UMBC | (1) Virginia | +20.5 |
| 1997 | (15) Coppin State | (2) South Carolina | +19 |
| 2022 | (15) Saint Peter's | (2) Kentucky | +18 |
| 2001 | (15) Hampton | (2) Iowa State | +17.5 |
| 2016 | (15) MTSU | (2) Michigan State | +16.5 |
| 2021 | (15) Oral Roberts | (2) Ohio State | +16.5 |
| 1999 | (15) Weber State | (2) North Carolina | +15 |
| 2024 | (13) Yale | (4) Auburn | +14.5 |
| 2023 | (15) Princeton | (2) Arizona | +14.5 |
| 2010 | (14) Ohio | (2) Georgetown | +14 |
| 2015 | (14) UAB | (3) Iowa State | +14 |
| 2024 | (14) Oakland | (3) Kentucky | +13.5 |
| 2005 | (14) Bucknell | (3) Kansas | +13 |
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